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Items: 1 to 20 of 142

1.

Niacin stimulates adiponectin secretion through the GPR109A receptor.

Plaisance EP, Lukasova M, Offermanns S, Zhang Y, Cao G, Judd RL.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E549-58. doi: 10.1152/ajpendo.91004.2008. Epub 2009 Jan 13.

2.

Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A.

Zhang Y, Schmidt RJ, Foxworthy P, Emkey R, Oler JK, Large TH, Wang H, Su EW, Mosior MK, Eacho PI, Cao G.

Biochem Biophys Res Commun. 2005 Aug 26;334(2):729-32.

PMID:
16018973
3.

Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81).

Jeninga EH, Bugge A, Nielsen R, Kersten S, Hamers N, Dani C, Wabitsch M, Berger R, Stunnenberg HG, Mandrup S, Kalkhoven E.

J Biol Chem. 2009 Sep 25;284(39):26385-93. doi: 10.1074/jbc.M109.040741. Epub 2009 Jul 24.

4.

Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G).

Ren N, Kaplan R, Hernandez M, Cheng K, Jin L, Taggart AK, Zhu AY, Gan X, Wright SD, Cai TQ.

J Lipid Res. 2009 May;50(5):908-14. doi: 10.1194/jlr.M800625-JLR200. Epub 2009 Jan 9.

5.

beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.

Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ.

J Clin Invest. 2009 May;119(5):1312-21. doi: 10.1172/JCI36806. Epub 2009 Apr 6.

6.

Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.

Lauring B, Taggart AK, Tata JR, Dunbar R, Caro L, Cheng K, Chin J, Colletti SL, Cote J, Khalilieh S, Liu J, Luo WL, Maclean AA, Peterson LB, Polis AB, Sirah W, Wu TJ, Liu X, Jin L, Wu K, Boatman PD, Semple G, Behan DP, Connolly DT, Lai E, Wagner JA, Wright SD, Cuffie C, Mitchel YB, Rader DJ, Paolini JF, Waters MG, Plump A.

Sci Transl Med. 2012 Aug 22;4(148):148ra115. doi: 10.1126/scitranslmed.3003877.

7.

Triglyceride modulation by acifran analogs: activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74.

Mahboubi K, Witman-Jones T, Adamus JE, Letsinger JT, Whitehouse D, Moorman AR, Sawicki D, Bergenhem N, Ross SA.

Biochem Biophys Res Commun. 2006 Feb 10;340(2):482-90. Epub 2005 Dec 19.

PMID:
16389067
8.

Nicotinic acid (niacin) receptor agonists: will they be useful therapeutic agents?

Kamanna VS, Kashyap ML.

Am J Cardiol. 2007 Dec 3;100(11 A):S53-61. Review.

PMID:
18047854
9.

Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists.

Carballo-Jane E, Gerckens LS, Luell S, Parlapiano AS, Wolff M, Colletti SL, Tata JR, Taggart AK, Waters MG, Richman JG, McCann ME, Forrest MJ.

J Pharmacol Toxicol Methods. 2007 Nov-Dec;56(3):308-16. Epub 2007 Jun 23.

PMID:
17643322
10.

(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.

Taggart AK, Kero J, Gan X, Cai TQ, Cheng K, Ippolito M, Ren N, Kaplan R, Wu K, Wu TJ, Jin L, Liaw C, Chen R, Richman J, Connolly D, Offermanns S, Wright SD, Waters MG.

J Biol Chem. 2005 Jul 22;280(29):26649-52. Epub 2005 Jun 1.

11.

Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A).

Kostylina G, Simon D, Fey MF, Yousefi S, Simon HU.

Cell Death Differ. 2008 Jan;15(1):134-42. Epub 2007 Oct 12.

12.

1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.

Semple G, Skinner PJ, Cherrier MC, Webb PJ, Sage CR, Tamura SY, Chen R, Richman JG, Connolly DT.

J Med Chem. 2006 Feb 23;49(4):1227-30.

PMID:
16480258
13.

Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.

Li X, Millar JS, Brownell N, Briand F, Rader DJ.

Biochem Pharmacol. 2010 Nov 1;80(9):1450-7. doi: 10.1016/j.bcp.2010.07.023. Epub 2010 Jul 22.

14.

Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.

Chen L, So WY, Li SY, Cheng Q, Boucher BJ, Leung PS.

Mol Cell Endocrinol. 2015 Mar 15;404:56-66. doi: 10.1016/j.mce.2015.01.029. Epub 2015 Jan 23.

PMID:
25622782
15.

Future of GPR109A agonists in the treatment of dyslipidaemia.

Wanders D, Judd RL.

Diabetes Obes Metab. 2011 Aug;13(8):685-91. doi: 10.1111/j.1463-1326.2011.01400.x. Review.

PMID:
21418500
16.

Nicotinic acid increases adiponectin secretion from differentiated bovine preadipocytes through G-protein coupled receptor signaling.

Kopp C, Hosseini A, Singh SP, Regenhard P, Khalilvandi-Behroozyar H, Sauerwein H, Mielenz M.

Int J Mol Sci. 2014 Nov 18;15(11):21401-18. doi: 10.3390/ijms151121401.

17.

Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids.

Ge H, Li X, Weiszmann J, Wang P, Baribault H, Chen JL, Tian H, Li Y.

Endocrinology. 2008 Sep;149(9):4519-26. doi: 10.1210/en.2008-0059. Epub 2008 May 22.

PMID:
18499755
18.

GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.

Gambhir D, Ananth S, Veeranan-Karmegam R, Elangovan S, Hester S, Jennings E, Offermanns S, Nussbaum JJ, Smith SB, Thangaraju M, Ganapathy V, Martin PM.

Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2208-17. doi: 10.1167/iovs.11-8447.

19.

Langerhans cells release prostaglandin D2 in response to nicotinic acid.

Maciejewski-Lenoir D, Richman JG, Hakak Y, Gaidarov I, Behan DP, Connolly DT.

J Invest Dermatol. 2006 Dec;126(12):2637-46. Epub 2006 Sep 28.

20.

3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.

Semple G, Skinner PJ, Gharbaoui T, Shin YJ, Jung JK, Cherrier MC, Webb PJ, Tamura SY, Boatman PD, Sage CR, Schrader TO, Chen R, Colletti SL, Tata JR, Waters MG, Cheng K, Taggart AK, Cai TQ, Carballo-Jane E, Behan DP, Connolly DT, Richman JG.

J Med Chem. 2008 Aug 28;51(16):5101-8. doi: 10.1021/jm800258p. Epub 2008 Jul 30.

PMID:
18665582

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