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The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome.

Vera J, Fenutría R, Cañadas O, Figueras M, Mota R, Sarrias MR, Williams DL, Casals C, Yelamos J, Lozano F.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1506-11. doi: 10.1073/pnas.0805846106. Epub 2009 Jan 13.


CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock.

Sarrias MR, Farnós M, Mota R, Sánchez-Barbero F, Ibáñez A, Gimferrer I, Vera J, Fenutría R, Casals C, Yélamos J, Lozano F.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11724-9. Epub 2007 Jun 29.


The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression.

Martinez VG, Escoda-Ferran C, Tadeu Simões I, Arai S, Orta Mascaró M, Carreras E, Martínez-Florensa M, Yelamos J, Miyazaki T, Lozano F.

Cell Mol Immunol. 2014 Jul;11(4):343-54. doi: 10.1038/cmi.2014.12. Epub 2014 Mar 3.


Targeting of key pathogenic factors from gram-positive bacteria by the soluble ectodomain of the scavenger-like lymphocyte receptor CD6.

Martínez-Florensa M, Consuegra-Fernández M, Martínez VG, Cañadas O, Armiger-Borràs N, Bonet-Roselló L, Farrán A, Vila J, Casals C, Lozano F.

J Infect Dis. 2014 Apr 1;209(7):1077-86. doi: 10.1093/infdis/jit624. Epub 2013 Nov 21.


Evolutionary and functional evidence for positive selection at the human CD5 immune receptor gene.

Carnero-Montoro E, Bonet L, Engelken J, Bielig T, Martínez-Florensa M, Lozano F, Bosch E.

Mol Biol Evol. 2012 Feb;29(2):811-23. doi: 10.1093/molbev/msr251. Epub 2011 Oct 13.


The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells.

Gimferrer I, Farnós M, Calvo M, Mittelbrunn M, Enrich C, Sánchez-Madrid F, Vives J, Lozano F.

J Biol Chem. 2003 Mar 7;278(10):8564-71. Epub 2002 Dec 8.


The ectodomains of the lymphocyte scavenger receptors CD5 and CD6 interact with tegumental antigens from Echinococcus granulosus sensu lato and protect mice against secondary cystic echinococcosis.

Mourglia-Ettlin G, Miles S, Velasco-De-Andrés M, Armiger-Borràs N, Cucher M, Dematteis S, Lozano F.

PLoS Negl Trop Dis. 2018 Nov 30;12(11):e0006891. doi: 10.1371/journal.pntd.0006891. eCollection 2018 Nov.


Crystal structure of the third extracellular domain of CD5 reveals the fold of a group B scavenger cysteine-rich receptor domain.

Rodamilans B, Muñoz IG, Bragado-Nilsson E, Sarrias MR, Padilla O, Blanco FJ, Lozano F, Montoya G.

J Biol Chem. 2007 Apr 27;282(17):12669-77. Epub 2007 Feb 23.


Identification of a natural soluble form of human CD5.

Calvo J, Places L, Espinosa G, Padilla O, Vilà JM, Villamor N, Ingelmo M, Gallart T, Vives J, Font J, Lozano F.

Tissue Antigens. 1999 Aug;54(2):128-37.


Genomic organization of the human CD5 gene.

Padilla O, Calvo J, Vilà JM, Arman M, Gimferrer I, Places L, Arias MT, Pujana MA, Vives J, Lozano F.

Immunogenetics. 2000 Oct;51(12):993-1001.


Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence.

Torosantucci A, Chiani P, Bromuro C, De Bernardis F, Palma AS, Liu Y, Mignogna G, Maras B, Colone M, Stringaro A, Zamboni S, Feizi T, Cassone A.

PLoS One. 2009;4(4):e5392. doi: 10.1371/journal.pone.0005392. Epub 2009 Apr 28.


A ligand for CD5 is CD5.

Brown MH, Lacey E.

J Immunol. 2010 Nov 15;185(10):6068-74. doi: 10.4049/jimmunol.0903823. Epub 2010 Oct 15.


Saccharomyces cerevisiae- and Candida albicans-derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD14- and Toll-like receptor 4-dependent manner.

Tada H, Nemoto E, Shimauchi H, Watanabe T, Mikami T, Matsumoto T, Ohno N, Tamura H, Shibata K, Akashi S, Miyake K, Sugawara S, Takada H.

Microbiol Immunol. 2002;46(7):503-12.


Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses.

Fenutría R, Martinez VG, Simões I, Postigo J, Gil V, Martínez-Florensa M, Sintes J, Naves R, Cashman KS, Alberola-Ila J, Ramos-Casals M, Soldevila G, Raman C, Merino J, Merino R, Engel P, Lozano F.

PLoS One. 2014 Jan 15;9(1):e84895. doi: 10.1371/journal.pone.0084895. eCollection 2014.


Elevated numbers of SCART1+ gammadelta T cells in skin inflammation and inflammatory bowel disease.

Fink DR, Holm D, Schlosser A, Nielsen O, Latta M, Lozano F, Holmskov U.

Mol Immunol. 2010 May;47(9):1710-8. doi: 10.1016/j.molimm.2010.03.002. Epub 2010 Apr 8.


Structural analysis of the CD5 antigen--expression, disulphide bond analysis and physical characterisation of CD5 scavenger receptor superfamily domain 1.

McAlister MS, Brown MH, Willis AC, Rudd PM, Harvey DJ, Aplin R, Shotton DM, Dwek RA, Barclay AN, Driscoll PC.

Eur J Biochem. 1998 Oct 1;257(1):131-41.


A comparison of the pulmonary inflammatory potential of different components of yeast cell wall.

Young SH, Ostroff GR, Zeidler-Erdely PC, Roberts JR, Antonini JM, Castranova V.

J Toxicol Environ Health A. 2007 Jul;70(13):1116-24.


Expression, purification and crystallization of human CD5 domain III, a nano-scale crystallization example.

Rodamilans B, Ibañez S, Bragado-Nilsson E, Sarrias MR, Lozano F, Blanco FJ, Montoya G.

J Struct Biol. 2007 Jul;159(1):144-8. Epub 2007 Jan 23.


Solubilized cell wall beta-glucan, CSBG, is an epitope of Candida immune mice.

Uchiyama M, Ohno N, Miura NN, Adachi Y, Tamura H, Tanaka S, Yadomae T.

Biol Pharm Bull. 2000 May;23(5):672-6.


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