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Items: 1 to 20 of 470

1.

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.

Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernández-Zapico ME, Hanahan D.

Genes Dev. 2009 Jan 1;23(1):24-36. doi: 10.1101/gad.1753809.

2.

Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer.

Onishi H, Kai M, Odate S, Iwasaki H, Morifuji Y, Ogino T, Morisaki T, Nakashima Y, Katano M.

Cancer Sci. 2011 Jun;102(6):1144-50. doi: 10.1111/j.1349-7006.2011.01912.x. Epub 2011 Mar 15.

3.

Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts.

Walter K, Omura N, Hong SM, Griffith M, Vincent A, Borges M, Goggins M.

Clin Cancer Res. 2010 Mar 15;16(6):1781-9. doi: 10.1158/1078-0432.CCR-09-1913. Epub 2010 Mar 9.

4.

Sonic hedgehog and Gli1 expression predict outcome in resected pancreatic adenocarcinoma.

Maréchal R, Bachet JB, Calomme A, Demetter P, Delpero JR, Svrcek M, Cros J, Bardier-Dupas A, Puleo F, Monges G, Hammel P, Louvet C, Paye F, Bachelier P, Le Treut YP, Vaillant JC, Sauvanet A, André T, Salmon I, Devière J, Emile JF, Van Laethem JL.

Clin Cancer Res. 2015 Mar 1;21(5):1215-24. doi: 10.1158/1078-0432.CCR-14-0667. Epub 2014 Dec 31.

5.

Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo.

Guo J, Gao J, Li Z, Gong Y, Man X, Jin J, Wu H.

Cancer Lett. 2013 Oct 10;339(2):185-94. doi: 10.1016/j.canlet.2013.06.010. Epub 2013 Jun 18.

PMID:
23791879
6.

Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation.

Mills LD, Zhang Y, Marler RJ, Herreros-Villanueva M, Zhang L, Almada LL, Couch F, Wetmore C, Pasca di Magliano M, Fernandez-Zapico ME.

J Biol Chem. 2013 Apr 26;288(17):11786-94. doi: 10.1074/jbc.M112.438846. Epub 2013 Mar 12.

7.

Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancer.

Onishi H, Yamasaki A, Kawamoto M, Imaizumi A, Katano M.

Cancer Lett. 2016 Feb 28;371(2):143-50. doi: 10.1016/j.canlet.2015.11.012. Epub 2015 Nov 30.

PMID:
26655998
8.

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.

Benvenuto M, Masuelli L, De Smaele E, Fantini M, Mattera R, Cucchi D, Bonanno E, Di Stefano E, Frajese GV, Orlandi A, Screpanti I, Gulino A, Modesti A, Bei R.

Oncotarget. 2016 Feb 23;7(8):9250-70. doi: 10.18632/oncotarget.7062.

9.

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner.

Lei J, Ma J, Ma Q, Li X, Liu H, Xu Q, Duan W, Sun Q, Xu J, Wu Z, Wu E.

Mol Cancer. 2013 Jun 20;12:66. doi: 10.1186/1476-4598-12-66.

10.

A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes.

Inagawa Y, Yamada K, Yugawa T, Ohno S, Hiraoka N, Esaki M, Shibata T, Aoki K, Saya H, Kiyono T.

Carcinogenesis. 2014 Aug;35(8):1840-6. doi: 10.1093/carcin/bgu112. Epub 2014 May 24.

PMID:
24858378
11.

Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines.

Yao J, An Y, Wie JS, Ji ZL, Lu ZP, Wu JL, Jiang KR, Chen P, Xu ZK, Miao Y.

Swiss Med Wkly. 2011 May 31;141:w13208. doi: 10.4414/smw.2011.13208.

12.

Role of sonic hedgehog signaling in migration of cell lines established from CD133-positive malignant glioma cells.

Uchida H, Arita K, Yunoue S, Yonezawa H, Shinsato Y, Kawano H, Hirano H, Hanaya R, Tokimura H.

J Neurooncol. 2011 Sep;104(3):697-704. doi: 10.1007/s11060-011-0552-2. Epub 2011 Mar 5.

PMID:
21380601
13.

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C.

Gastroenterology. 2014 Nov;147(5):1119-33.e4. doi: 10.1053/j.gastro.2014.08.002. Epub 2014 Aug 12.

PMID:
25127677
14.

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, Kühnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E.

Gastroenterology. 2015 May;148(5):1024-1034.e9. doi: 10.1053/j.gastro.2015.01.033. Epub 2015 Jan 23.

15.

The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients.

He M, Fu Y, Yan Y, Xiao Q, Wu H, Yao W, Zhao H, Zhao L, Jiang Q, Yu Z, Jin F, Mi X, Wang E, Cui Z, Fu L, Chen J, Wei M.

Clin Sci (Lond). 2015 Nov;129(9):809-22. doi: 10.1042/CS20140592. Epub 2015 Jul 2.

PMID:
26201092
16.

The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1.

Genrich G, Kruppa M, Lenk L, Helm O, Broich A, Freitag-Wolf S, Röcken C, Sipos B, Schäfer H, Sebens S.

BMC Cancer. 2016 Feb 25;16:155. doi: 10.1186/s12885-016-2191-7.

17.

Expressions of sonic hedgehog, patched, smoothened and Gli-1 in human intestinal stromal tumors and their correlation with prognosis.

Yoshizaki A, Nakayama T, Naito S, Wen CY, Sekine I.

World J Gastroenterol. 2006 Sep 21;12(35):5687-91.

18.

Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium.

Carbe CJ, Cheng L, Addya S, Gold JI, Gao E, Koch WJ, Riobo NA.

Am J Physiol Heart Circ Physiol. 2014 Jul 1;307(1):H66-72. doi: 10.1152/ajpheart.00166.2014. Epub 2014 May 9.

19.

Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation.

Yao PJ, Petralia RS, Ott C, Wang YX, Lippincott-Schwartz J, Mattson MP.

J Neurosci. 2015 Dec 9;35(49):16126-41. doi: 10.1523/JNEUROSCI.1360-15.2015.

20.

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.

Hu MC, Mo R, Bhella S, Wilson CW, Chuang PT, Hui CC, Rosenblum ND.

Development. 2006 Feb;133(3):569-78. Epub 2006 Jan 5.

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