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Endoplasmic reticulum stress plays a central role in development of leptin resistance.

Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, Myers MG Jr, Ozcan U.

Cell Metab. 2009 Jan 7;9(1):35-51. doi: 10.1016/j.cmet.2008.12.004.


Chronic sleep fragmentation during the sleep period induces hypothalamic endoplasmic reticulum stress and PTP1b-mediated leptin resistance in male mice.

Hakim F, Wang Y, Carreras A, Hirotsu C, Zhang J, Peris E, Gozal D.

Sleep. 2015 Jan 1;38(1):31-40. doi: 10.5665/sleep.4320.


Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.

Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y.

J Neurochem. 2006 Jun;97(5):1259-68. Epub 2006 Mar 15.


Endoplasmic reticulum stress induces leptin resistance.

Hosoi T, Sasaki M, Miyahara T, Hashimoto C, Matsuo S, Yoshii M, Ozawa K.

Mol Pharmacol. 2008 Dec;74(6):1610-9. doi: 10.1124/mol.108.050070. Epub 2008 Aug 28.


Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats.

Mulhern ML, Madson CJ, Kador PF, Randazzo J, Shinohara T.

Mol Vis. 2007 Aug 10;13:1397-405.


Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease.

Gregor MF, Hotamisligil GS.

J Lipid Res. 2007 Sep;48(9):1905-14. Epub 2007 May 9. Review.


Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis.

Seyhun E, Malo A, Schäfer C, Moskaluk CA, Hoffmann RT, Göke B, Kubisch CH.

Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G773-82. doi: 10.1152/ajpgi.00483.2010. Epub 2011 Jul 21.


Structure-function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cells.

Berger E, Haller D.

Biochem Biophys Res Commun. 2011 Jun 17;409(4):610-5. doi: 10.1016/j.bbrc.2011.05.043. Epub 2011 May 14.


Three weeks voluntary running wheel exercise increases endoplasmic reticulum stress in the brain of mice.

Kim Y, Park M, Boghossian S, York DA.

Brain Res. 2010 Mar 4;1317:13-23. doi: 10.1016/j.brainres.2009.12.062. Epub 2010 Jan 4.


Reduction of endoplasmic reticulum stress using chemical chaperones or Grp78 overexpression does not protect muscle cells from palmitate-induced insulin resistance.

Rieusset J, Chauvin MA, Durand A, Bravard A, Laugerette F, Michalski MC, Vidal H.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):439-45. doi: 10.1016/j.bbrc.2011.11.135. Epub 2011 Dec 7.


Endoplasmic reticulum stress participates in aortic valve calcification in hypercholesterolemic animals.

Cai Z, Li F, Gong W, Liu W, Duan Q, Chen C, Ni L, Xia Y, Cianflone K, Dong N, Wang DW.

Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2345-54. doi: 10.1161/ATVBAHA.112.300226. Epub 2013 Aug 8.


Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin.

Won JC, Jang PG, Namkoong C, Koh EH, Kim SK, Park JY, Lee KU, Kim MS.

Obesity (Silver Spring). 2009 Oct;17(10):1861-5. doi: 10.1038/oby.2009.194. Epub 2009 Jun 18.


Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass.

Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G.

Cell. 2000 Jan 21;100(2):197-207.


Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice.

Amin A, Choi SK, Galan M, Kassan M, Partyka M, Kadowitz P, Henrion D, Trebak M, Belmadani S, Matrougui K.

J Pathol. 2012 Jun;227(2):165-74. doi: 10.1002/path.3960. Epub 2012 Feb 17.


Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes.

Chen Y, Liu CP, Xu KF, Mao XD, Lu YB, Fang L, Yang JW, Liu C.

Am J Nephrol. 2008;28(6):1014-22. doi: 10.1159/000148209. Epub 2008 Jul 23.


Chemical chaperones reduce ionizing radiation-induced endoplasmic reticulum stress and cell death in IEC-6 cells.

Lee ES, Lee HJ, Lee YJ, Jeong JH, Kang S, Lim YB.

Biochem Biophys Res Commun. 2014 Jul 25;450(2):1005-9. doi: 10.1016/j.bbrc.2014.06.091. Epub 2014 Jun 25.


GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.

Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, Ferré P, Foufelle F.

J Clin Invest. 2009 May;119(5):1201-15. doi: 10.1172/JCI37007. Epub 2009 Apr 13.


Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity.

Kim GW, Lin JE, Snook AE, Aing AS, Merlino DJ, Li P, Waldman SA.

Nutr Diabetes. 2016 May 23;6:e211. doi: 10.1038/nutd.2016.18.


Changes in the neuroendocrine control of energy homeostasis by adiposity signals during aging.

Carrascosa JM, Ros M, Andrés A, Fernández-Agulló T, Arribas C.

Exp Gerontol. 2009 Jan-Feb;44(1-2):20-5. doi: 10.1016/j.exger.2008.05.005. Epub 2008 May 20. Review.


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