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Structural basis for cross-resistance to ribosomal PTC antibiotics.

Davidovich C, Bashan A, Yonath A.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20665-70. doi: 10.1073/pnas.0810826105. Epub 2008 Dec 19.


Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.

Dunkle JA, Xiong L, Mankin AS, Cate JH.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17152-7. doi: 10.1073/pnas.1007988107. Epub 2010 Sep 27.


Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction.

Schmeing TM, Huang KS, Kitchen DE, Strobel SA, Steitz TA.

Mol Cell. 2005 Nov 11;20(3):437-48.


Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.

Osterman IA, Khabibullina NF, Komarova ES, Kasatsky P, Kartsev VG, Bogdanov AA, Dontsova OA, Konevega AL, Sergiev PV, Polikanov YS.

Nucleic Acids Res. 2017 Jul 7;45(12):7507-7514. doi: 10.1093/nar/gkx413.


Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit.

Simonović M, Steitz TA.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):500-5. doi: 10.1073/pnas.0711076105. Epub 2008 Jan 10.


Ribosomal antibiotics: structural basis for resistance, synergism and selectivity.

Auerbach T, Bashan A, Yonath A.

Trends Biotechnol. 2004 Nov;22(11):570-6. Review.


Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket.

Long KS, Poehlsgaard J, Hansen LH, Hobbie SN, Böttger EC, Vester B.

Mol Microbiol. 2009 Mar;71(5):1218-27. doi: 10.1111/j.1365-2958.2009.06596.x. Epub 2009 Jan 16.


Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria.

Schlünzen F, Zarivach R, Harms J, Bashan A, Tocilj A, Albrecht R, Yonath A, Franceschi F.

Nature. 2001 Oct 25;413(6858):814-21.


Revisiting the structures of several antibiotics bound to the bacterial ribosome.

Bulkley D, Innis CA, Blaha G, Steitz TA.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17158-63. doi: 10.1073/pnas.1008685107. Epub 2010 Sep 27.


Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity.

Davidovich C, Bashan A, Auerbach-Nevo T, Yaggie RD, Gontarek RR, Yonath A.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4291-6. Epub 2007 Mar 8.


Inhibition of Escherichia coli ribosome subunit dissociation by chloramphenicol and Blasticidin: a new mode of action of the antibiotics.

Pathak BK, Mondal S, Barat C.

Lett Appl Microbiol. 2017 Jan;64(1):79-85. doi: 10.1111/lam.12686. Epub 2016 Nov 24.


The structures of four macrolide antibiotics bound to the large ribosomal subunit.

Hansen JL, Ippolito JA, Ban N, Nissen P, Moore PB, Steitz TA.

Mol Cell. 2002 Jul;10(1):117-28.

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