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Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release.

Hsieh J, Walker SC, Fierke CA, Engelke DR.

RNA. 2009 Feb;15(2):224-34. doi: 10.1261/rna.1309409. Epub 2008 Dec 17.


Effects of 5' leader and 3' trailer structures on pre-tRNA processing by nuclear RNase P.

Ziehler WA, Day JJ, Fierke CA, Engelke DR.

Biochemistry. 2000 Aug 15;39(32):9909-16.


Dimeric and monomeric Bacillus subtilis RNase P holoenzyme in the absence and presence of pre-tRNA substrates.

Barrera A, Fang X, Jacob J, Casey E, Thiyagarajan P, Pan T.

Biochemistry. 2002 Oct 29;41(43):12986-94.


Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage.

Niranjanakumari S, Day-Storms JJ, Ahmed M, Hsieh J, Zahler NH, Venters RA, Fierke CA.

RNA. 2007 Apr;13(4):521-35. Epub 2007 Feb 13.


Mechanistic Studies Reveal Similar Catalytic Strategies for Phosphodiester Bond Hydrolysis by Protein-only and RNA-dependent Ribonuclease P.

Howard MJ, Klemm BP, Fierke CA.

J Biol Chem. 2015 May 22;290(21):13454-64. doi: 10.1074/jbc.M115.644831. Epub 2015 Mar 27.


The RNR motif of B. subtilis RNase P protein interacts with both PRNA and pre-tRNA to stabilize an active conformer.

Koutmou KS, Day-Storms JJ, Fierke CA.

RNA. 2011 Jul;17(7):1225-35. doi: 10.1261/rna.2742511. Epub 2011 May 27.


Characterization of conserved sequence elements in eukaryotic RNase P RNA reveals roles in holoenzyme assembly and tRNA processing.

Xiao S, Day-Storms JJ, Srisawat C, Fierke CA, Engelke DR.

RNA. 2005 Jun;11(6):885-96. Epub 2005 May 4.


Binding of C5 protein to P RNA enhances the rate constant for catalysis for P RNA processing of pre-tRNAs lacking a consensus (+ 1)/C(+ 72) pair.

Sun L, Campbell FE, Yandek LE, Harris ME.

J Mol Biol. 2010 Feb 5;395(5):1019-37. doi: 10.1016/j.jmb.2009.11.027. Epub 2009 Nov 13.


A divalent cation stabilizes the active conformation of the B. subtilis RNase P x pre-tRNA complex: a role for an inner-sphere metal ion in RNase P.

Hsieh J, Koutmou KS, Rueda D, Koutmos M, Walter NG, Fierke CA.

J Mol Biol. 2010 Jul 2;400(1):38-51. doi: 10.1016/j.jmb.2010.04.050. Epub 2010 Apr 29.


Product release is a rate-limiting step during cleavage by the catalytic RNA subunit of Escherichia coli RNase P.

Tallsjö A, Kirsebom LA.

Nucleic Acids Res. 1993 Jan 11;21(1):51-7. Erratum in: Nucleic Acids Res 1993 Apr 11;21(7):1686.


Substrate discrimination in RNase P RNA-mediated cleavage: importance of the structural environment of the RNase P cleavage site.

Kikovska E, Brännvall M, Kufel J, Kirsebom LA.

Nucleic Acids Res. 2005 Apr 7;33(6):2012-21. Print 2005.


Structure of a bacterial ribonuclease P holoenzyme in complex with tRNA.

Reiter NJ, Osterman A, Torres-Larios A, Swinger KK, Pan T, Mondragón A.

Nature. 2010 Dec 9;468(7325):784-9. doi: 10.1038/nature09516. Epub 2010 Nov 14.


Recognition of a pre-tRNA substrate by the Bacillus subtilis RNase P holoenzyme.

Loria A, Niranjanakumari S, Fierke CA, Pan T.

Biochemistry. 1998 Nov 3;37(44):15466-73.


Protein component of Bacillus subtilis RNase P specifically enhances the affinity for precursor-tRNAAsp.

Kurz JC, Niranjanakumari S, Fierke CA.

Biochemistry. 1998 Feb 24;37(8):2393-400.


Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP.

Xiao S, Hsieh J, Nugent RL, Coughlin DJ, Fierke CA, Engelke DR.

RNA. 2006 Jun;12(6):1023-37. Epub 2006 Apr 17.

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