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Items: 1 to 20 of 79

1.

Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain.

Campbell CM, Edwards RR, Carmona C, Uhart M, Wand G, Carteret A, Kim YK, Frost J, Campbell JN.

Pain. 2009 Jan;141(1-2):114-8. doi: 10.1016/j.pain.2008.10.023. Epub 2008 Dec 9.

2.

Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.

Lötsch J, Belfer I, Kirchhof A, Mishra BK, Max MB, Doehring A, Costigan M, Woolf CJ, Geisslinger G, Tegeder I.

Clin Chem. 2007 Jun;53(6):1010-5. Epub 2007 Mar 15.

3.

Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care.

Doehring A, Freynhagen R, Griessinger N, Zimmermann M, Sittl R, Hentig Nv, Geisslinger G, Lötsch J.

Clin J Pain. 2009 Nov-Dec;25(9):781-5. doi: 10.1097/AJP.0b013e3181b43e12.

PMID:
19851158
5.

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.

Tegeder I, Adolph J, Schmidt H, Woolf CJ, Geisslinger G, Lötsch J.

Eur J Pain. 2008 Nov;12(8):1069-77. doi: 10.1016/j.ejpain.2008.02.004. Epub 2008 Apr 18.

PMID:
18374612
6.

Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: a genetic association study.

Wadley AL, Lombard Z, Cherry CL, Price P, Kamerman PR.

J Acquir Immune Defic Syndr. 2012 May 1;60(1):20-3. doi: 10.1097/QAI.0b013e31824bcc17.

PMID:
22293547
7.

Association of guanosine triphosphate cyclohydrolase 1 gene polymorphisms with fibromyalgia syndrome in a Korean population.

Kim SK, Kim SH, Nah SS, Lee JH, Hong SJ, Kim HS, Lee HS, Kim HA, Joung CI, Bae J, Choe JY, Lee SS.

J Rheumatol. 2013 Mar;40(3):316-22. doi: 10.3899/jrheum.120929. Epub 2013 Jan 15.

PMID:
23322459
8.

Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain.

Nasser A, Bjerrum OJ, Heegaard AM, Møller AT, Larsen M, Dalbøge LS, Dupont E, Jensen TS, Møller LB.

Mol Pain. 2013 Feb 19;9:5. doi: 10.1186/1744-8069-9-5.

9.

Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.

Nasser A, Møller AT, Hellmund V, Thorborg SS, Jespersgaard C, Bjerrum OJ, Dupont E, Nachman G, Lykkesfeldt J, Jensen TS, Møller LB.

Pain. 2018 Jun;159(6):1012-1024. doi: 10.1097/j.pain.0000000000001175.

PMID:
29470312
10.

Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk.

Doehring A, Antoniades C, Channon KM, Tegeder I, Lötsch J.

Mutat Res. 2008 Sep-Oct;659(3):195-201. doi: 10.1016/j.mrrev.2008.04.007. Epub 2008 Apr 26. Review.

PMID:
18515178
11.

Polymorphic variation of the guanosine triphosphate cyclohydrolase 1 gene predicts outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.

Kim DH, Dai F, Belfer I, Banco RJ, Martha JF, Tighiouart H, Tromanhauser SG, Jenis LG, Hunter DJ, Schwartz CE.

Spine (Phila Pa 1976). 2010 Oct 1;35(21):1909-14. doi: 10.1097/BRS.0b013e3181eea007.

PMID:
20838263
12.

A GTP cyclohydrolase 1 genetic variant delays cancer pain.

Lötsch J, Klepstad P, Doehring A, Dale O.

Pain. 2010 Jan;148(1):103-6. doi: 10.1016/j.pain.2009.10.021. Epub 2009 Dec 2.

PMID:
19959292
13.

Do genetic predictors of pain sensitivity associate with persistent widespread pain?

Holliday KL, Nicholl BI, Macfarlane GJ, Thomson W, Davies KA, McBeth J.

Mol Pain. 2009 Sep 23;5:56. doi: 10.1186/1744-8069-5-56.

14.

Association of functional variations in COMT and GCH1 genes with postherniotomy pain and related impairment.

Belfer I, Dai F, Kehlet H, Finelli P, Qin L, Bittner R, Aasvang EK.

Pain. 2015 Feb;156(2):273-9. doi: 10.1097/01.j.pain.0000460307.48701.b0.

PMID:
25599448
15.

GCH1-polymorphism and pain sensitivity among women with provoked vestibulodynia.

Heddini U, Bohm-Starke N, Grönbladh A, Nyberg F, Nilsson KW, Johannesson U.

Mol Pain. 2012 Sep 12;8:68. doi: 10.1186/1744-8069-8-68.

16.

Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?

Lazarev M, Lamb J, Barmada MM, Dai F, Anderson MA, Max MB, Whitcomb DC.

Mol Pain. 2008 Nov 17;4:58. doi: 10.1186/1744-8069-4-58.

17.

Genetic variants of GCH1 associate with chronic and acute crisis pain in African Americans with sickle cell disease.

Sadhu N, Jhun EH, Yao Y, He Y, Molokie RE, Wilkie DJ, Wang ZJ.

Exp Hematol. 2018 Oct;66:42-49. doi: 10.1016/j.exphem.2018.07.004. Epub 2018 Jul 19.

PMID:
30031848
18.

Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.

Zhang L, Rao F, Zhang K, Khandrika S, Das M, Vaingankar SM, Bao X, Rana BK, Smith DW, Wessel J, Salem RM, Rodriguez-Flores JL, Mahata SK, Schork NJ, Ziegler MG, O'Connor DT.

J Clin Invest. 2007 Sep;117(9):2658-71.

19.

KCNS1, but not GCH1, is associated with pain intensity in a black southern African population with HIV-associated sensory neuropathy: a genetic association study.

Hendry L, Lombard Z, Wadley A, Kamerman P.

J Acquir Immune Defic Syndr. 2013 May 1;63(1):27-30. doi: 10.1097/QAI.0b013e318285cf36.

PMID:
23314412
20.

Functional polymorphism of the GTP cyclohydrolase 1 gene affects the personality trait of novelty seeking in healthy subjects.

Sadahiro R, Suzuki A, Matsumoto Y, Shibuya N, Enokido M, Kamata M, Goto K, Otani K.

Neurosci Lett. 2011 Oct 10;503(3):220-3. doi: 10.1016/j.neulet.2011.08.040. Epub 2011 Aug 27.

PMID:
21896313

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