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Items: 1 to 20 of 89

1.

TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA.

Chockalingam A, Brooks JC, Cameron JL, Blum LK, Leifer CA.

Immunol Cell Biol. 2009 Mar-Apr;87(3):209-17. doi: 10.1038/icb.2008.101. Epub 2008 Dec 16.

2.

TLR9 signals after translocating from the ER to CpG DNA in the lysosome.

Latz E, Schoenemeyer A, Visintin A, Fitzgerald KA, Monks BG, Knetter CF, Lien E, Nilsen NJ, Espevik T, Golenbock DT.

Nat Immunol. 2004 Feb;5(2):190-8. Epub 2004 Jan 11.

PMID:
14716310
3.

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM.

Nature. 2008 Dec 4;456(7222):658-62. doi: 10.1038/nature07405. Epub 2008 Sep 28.

4.

CpG oligonucleotides induce an immune response of odontoblasts through the TLR9, MyD88 and NF-kappaB pathways.

He W, Yu Q, Zhou Z, Wang P.

Biochem Biophys Res Commun. 2010 Aug 20;399(2):274-8. doi: 10.1016/j.bbrc.2010.07.068. Epub 2010 Jul 21.

PMID:
20655295
5.

An oligodeoxynucleotide with CCT repeats restrains CpG ODN-induced TLR9 trafficking.

Zhang X, Sun W, Wu X, Wang H, Yan Y, Guo S, Song D, Li H, Gao S, Wang L, Yu Y, Wang L.

Curr Pharm Biotechnol. 2014;15(9):780-9.

PMID:
25374030
6.

Regulatory molecules required for nucleotide-sensing Toll-like receptors.

Saitoh S, Miyake K.

Immunol Rev. 2009 Jan;227(1):32-43. doi: 10.1111/j.1600-065X.2008.00729.x. Review.

PMID:
19120473
7.

Mechanisms of TLR9 activation.

Latz E, Visintin A, Espevik T, Golenbock DT.

J Endotoxin Res. 2004;10(6):406-12.

PMID:
15588423
8.

Cytidine-phosphate-guanosine oligonucleotides induce interleukin-8 production through activation of TLR9, MyD88, NF-κB, and ERK pathways in odontoblast cells.

He W, Zhang Y, Zhang J, Yu Q, Wang P, Wang Z, Smith AJ.

J Endod. 2012 Jun;38(6):780-5. doi: 10.1016/j.joen.2012.02.026. Epub 2012 Apr 4.

PMID:
22595112
9.

A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.

Ivanov S, Dragoi AM, Wang X, Dallacosta C, Louten J, Musco G, Sitia G, Yap GS, Wan Y, Biron CA, Bianchi ME, Wang H, Chu WM.

Blood. 2007 Sep 15;110(6):1970-81. Epub 2007 Jun 4.

10.

Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability.

Brooks JC, Sun W, Chiosis G, Leifer CA.

Biochem Biophys Res Commun. 2012 May 18;421(4):780-4. doi: 10.1016/j.bbrc.2012.04.083. Epub 2012 Apr 23.

11.
12.

Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi.

Bartholomeu DC, Ropert C, Melo MB, Parroche P, Junqueira CF, Teixeira SM, Sirois C, Kasperkovitz P, Knetter CF, Lien E, Latz E, Golenbock DT, Gazzinelli RT.

J Immunol. 2008 Jul 15;181(2):1333-44.

13.

DNase II-dependent DNA digestion is required for DNA sensing by TLR9.

Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh S, Ohto U, Shimizu T, Barber GN, Miyake K.

Nat Commun. 2015 Jan 20;6:5853. doi: 10.1038/ncomms6853.

PMID:
25600358
14.

Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes.

Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR.

J Immunol. 2009 Sep 1;183(5):3109-17. doi: 10.4049/jimmunol.0900399. Epub 2009 Jul 31.

15.

Chicken TLR21 is an innate CpG DNA receptor distinct from mammalian TLR9.

Keestra AM, de Zoete MR, Bouwman LI, van Putten JP.

J Immunol. 2010 Jul 1;185(1):460-7. doi: 10.4049/jimmunol.0901921. Epub 2010 May 24.

16.

Cytoplasmic targeting motifs control localization of toll-like receptor 9.

Leifer CA, Brooks JC, Hoelzer K, Lopez J, Kennedy MN, Mazzoni A, Segal DM.

J Biol Chem. 2006 Nov 17;281(46):35585-92. Epub 2006 Sep 21.

17.

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9.

Park B, Brinkmann MM, Spooner E, Lee CC, Kim YM, Ploegh HL.

Nat Immunol. 2008 Dec;9(12):1407-14. doi: 10.1038/ni.1669. Epub 2008 Oct 19.

18.

Cathepsins are required for Toll-like receptor 9 responses.

Matsumoto F, Saitoh S, Fukui R, Kobayashi T, Tanimura N, Konno K, Kusumoto Y, Akashi-Takamura S, Miyake K.

Biochem Biophys Res Commun. 2008 Mar 14;367(3):693-9. doi: 10.1016/j.bbrc.2007.12.130. Epub 2007 Dec 31.

PMID:
18166152
19.

Endoplasmic Protein Nogo-B (RTN4-B) Interacts with GRAMD4 and Regulates TLR9-Mediated Innate Immune Responses.

Kimura T, Endo S, Inui M, Saitoh S, Miyake K, Takai T.

J Immunol. 2015 Jun 1;194(11):5426-36. doi: 10.4049/jimmunol.1402006. Epub 2015 Apr 27.

20.

Ligand-induced conformational changes allosterically activate Toll-like receptor 9.

Latz E, Verma A, Visintin A, Gong M, Sirois CM, Klein DC, Monks BG, McKnight CJ, Lamphier MS, Duprex WP, Espevik T, Golenbock DT.

Nat Immunol. 2007 Jul;8(7):772-9. Epub 2007 Jun 17.

PMID:
17572678

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