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Items: 1 to 20 of 112


Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation.

Kohler JJ, Hosseini SH, Cucoranu I, Hoying-Brandt A, Green E, Johnson D, Wittich B, Srivastava J, Ivey K, Fields E, Russ R, Raper CM, Santoianni R, Lewis W.

Lab Invest. 2009 Feb;89(2):122-30. doi: 10.1038/labinvest.2008.121. Epub 2008 Dec 15.


Cardiac-targeted transgenic mutant mitochondrial enzymes: mtDNA defects, antiretroviral toxicity and cardiomyopathy.

Kohler JJ, Hosseini SH, Green E, Hoying-Brandt A, Cucoranu I, Haase CP, Russ R, Srivastava J, Ivey K, Ludaway T, Kapoor V, Abuin A, Shapoval A, Santoianni R, Saada A, Elpeleg O, Lewis W.

Cardiovasc Toxicol. 2008 Summer;8(2):57-69. doi: 10.1007/s12012-008-9015-1. Epub 2008 Apr 30.


Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals.

Hosseini SH, Kohler JJ, Haase CP, Tioleco N, Stuart T, Keebaugh E, Ludaway T, Russ R, Green E, Long R, Wang L, Eriksson S, Lewis W.

Am J Pathol. 2007 Mar;170(3):865-74.


Transgenic cardiac-targeted overexpression of human thymidylate kinase.

Kohler JJ, Hosseini SH, Cucoranu I, Zhelyabovska O, Green E, Ivey K, Abuin A, Fields E, Hoying A, Russ R, Santoianni R, Raper CM, Yang Q, Lavie A, Lewis W.

Lab Invest. 2010 Mar;90(3):383-90. doi: 10.1038/labinvest.2009.146. Epub 2010 Jan 11.


Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.

Lewis W, Kohler JJ, Hosseini SH, Haase CP, Copeland WC, Bienstock RJ, Ludaway T, McNaught J, Russ R, Stuart T, Santoianni R.

AIDS. 2006 Mar 21;20(5):675-84.


Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis.

Koczor CA, Torres RA, Fields E, Qin Q, Park J, Ludaway T, Russ R, Lewis W.

Lab Invest. 2013 Feb;93(2):151-8. doi: 10.1038/labinvest.2012.146. Epub 2012 Oct 22.


Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.

Chan SS, Santos JH, Meyer JN, Mandavilli BS, Cook DL Jr, McCash CL, Kissling GE, Nyska A, Foley JF, van Houten B, Copeland WC, Walker VE, Witt KL, Bishop JB.

Environ Mol Mutagen. 2007 Apr-May;48(3-4):190-200.


Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS.

Lewis W, Haase CP, Miller YK, Ferguson B, Stuart T, Ludaway T, McNaught J, Russ R, Steltzer J, Santoianni R, Long R, Fiermonte G, Palmieri F.

Lab Invest. 2005 Aug;85(8):972-81.


In utero exposure of female CD-1 mice to AZT and/or 3TC: II. Persistence of functional alterations in cardiac tissue.

Torres SM, Divi RL, Walker DM, McCash CL, Carter MM, Campen MJ, Einem TL, Chu Y, Seilkop SK, Kang H, Poirier MC, Walker VE.

Cardiovasc Toxicol. 2010 Jun;10(2):87-99. doi: 10.1007/s12012-010-9065-z.


In utero exposure of female CD-1 Mice to AZT and/or 3TC: I. Persistence of microscopic lesions in cardiac tissue.

Torres SM, March TH, Carter MM, McCash CL, Seilkop SK, Poirier MC, Walker DM, Walker VE.

Cardiovasc Toxicol. 2010 Mar;10(1):37-50. doi: 10.1007/s12012-010-9061-3.


Absence of mitochondrial toxicity in hearts of transgenic mice treated with abacavir.

Kohler JJ, Hosseini SH, Green E, Fields E, Abuin A, Ludaway T, Russ R, Lewis W.

Cardiovasc Toxicol. 2010 Jun;10(2):146-51. doi: 10.1007/s12012-010-9070-2.


Transgenic mitochondrial superoxide dismutase and mitochondrially targeted catalase prevent antiretroviral-induced oxidative stress and cardiomyopathy.

Kohler JJ, Cucoranu I, Fields E, Green E, He S, Hoying A, Russ R, Abuin A, Johnson D, Hosseini SH, Raper CM, Lewis W.

Lab Invest. 2009 Jul;89(7):782-90. doi: 10.1038/labinvest.2009.39. Epub 2009 Apr 27.


Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma.

Lewis W, Day BJ, Kohler JJ, Hosseini SH, Chan SS, Green EC, Haase CP, Keebaugh ES, Long R, Ludaway T, Russ R, Steltzer J, Tioleco N, Santoianni R, Copeland WC.

Lab Invest. 2007 Apr;87(4):326-35. Epub 2006 Feb 19.


Transgenic mouse models of mitochondrial toxicity associated with HIV/AIDS and antiretrovirals.

Koczor C, Kohler J, Lewis W.

Methods. 2010 Aug;51(4):399-404. doi: 10.1016/j.ymeth.2009.12.013. Epub 2010 Jan 4. Review.


Persistence of mitochondrial toxicity in hearts of female B6C3F1 mice exposed in utero to 3'-azido-3'-deoxythymidine.

Walker DM, Poirier MC, Campen MJ, Cook DL Jr, Divi RL, Nagashima K, Lund AK, Cossey PY, Hahn FF, Walker VE.

Cardiovasc Toxicol. 2004;4(2):133-53.


Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity.

Divi RL, Leonard SL, Kuo MM, Nagashima K, Thamire C, St Claire MC, Wade NA, Walker VE, Poirier MC.

Environ Mol Mutagen. 2007 Apr-May;48(3-4):201-9.


Cardiac mitochondrial compromise in 1-yr-old Erythrocebus patas monkeys perinatally-exposed to nucleoside reverse transcriptase inhibitors.

Divi RL, Leonard SL, Kuo MM, Walker BL, Orozco CC, St Claire MC, Nagashima K, Harbaugh SW, Harbaugh JW, Thamire C, Sable CA, Poirier MC.

Cardiovasc Toxicol. 2005;5(3):333-46.


Role of pyrimidine depletion in the mitochondrial cardiotoxicity of nucleoside analogue reverse transcriptase inhibitors.

Balcarek K, Venhoff N, Deveaud C, Beauvoit B, Bonnet J, Kirschner J, Venhoff AC, Lebrecht D, Walker UA.

J Acquir Immune Defic Syndr. 2010 Dec 15;55(5):550-7. doi: 10.1097/QAI.0b013e3181f25946.


Progressive mitochondrial compromise in brains and livers of primates exposed in utero to nucleoside reverse transcriptase inhibitors (NRTIs).

Divi RL, Einem TL, Fletcher SL, Shockley ME, Kuo MM, St Claire MC, Cook A, Nagashima K, Harbaugh SW, Harbaugh JW, Poirier MC.

Toxicol Sci. 2010 Nov;118(1):191-201. doi: 10.1093/toxsci/kfq235. Epub 2010 Aug 11.


Erythrocebus patas monkey offspring exposed perinatally to NRTIs sustain skeletal muscle mitochondrial compromise at birth and at 1 year of age.

Divi RL, Leonard SL, Walker BL, Kuo MM, Shockley ME, St Claire MC, Nagashima K, Harbaugh SW, Harbaugh JW, Poirier MC.

Toxicol Sci. 2007 Sep;99(1):203-13. Epub 2007 Jun 1.


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