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Items: 1 to 20 of 107


IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.

Jin H, Oyoshi MK, Le Y, Bianchi T, Koduru S, Mathias CB, Kumar L, Le Bras S, Young D, Collins M, Grusby MJ, Wenzel J, Bieber T, Boes M, Silberstein LE, Oettgen HC, Geha RS.

J Clin Invest. 2009 Jan;119(1):47-60. doi: 10.1172/JCI32310. Epub 2008 Dec 15.


The prostaglandin Dâ‚‚ receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge.

He R, Oyoshi MK, Wang JY, Hodge MR, Jin H, Geha RS.

J Allergy Clin Immunol. 2010 Oct;126(4):784-90. doi: 10.1016/j.jaci.2010.07.006. Epub 2010 Aug 14.


Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis.

Saegusa J, Hsu DK, Chen HY, Yu L, Fermin A, Fung MA, Liu FT.

Am J Pathol. 2009 Mar;174(3):922-31. doi: 10.2353/ajpath.2009.080500. Epub 2009 Jan 29.


COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization.

Laouini D, Elkhal A, Yalcindag A, Kawamoto S, Oettgen H, Geha RS.

J Allergy Clin Immunol. 2005 Aug;116(2):390-6.


Epicutaneous sensitization with superantigen induces allergic skin inflammation.

Laouini D, Kawamoto S, Yalcindag A, Bryce P, Mizoguchi E, Oettgen H, Geha RS.

J Allergy Clin Immunol. 2003 Nov;112(5):981-7.


Mechanical injury polarizes skin dendritic cells to elicit a T(H)2 response by inducing cutaneous thymic stromal lymphopoietin expression.

Oyoshi MK, Larson RP, Ziegler SF, Geha RS.

J Allergy Clin Immunol. 2010 Nov;126(5):976-84, 984.e1-5. doi: 10.1016/j.jaci.2010.08.041.


CD19 expression in B cells regulates atopic dermatitis in a mouse model.

Yanaba K, Kamata M, Asano Y, Tada Y, Sugaya M, Kadono T, Tedder TF, Sato S.

Am J Pathol. 2013 Jun;182(6):2214-22. doi: 10.1016/j.ajpath.2013.02.042. Epub 2013 Apr 12.


Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis.

Spergel JM, Mizoguchi E, Oettgen H, Bhan AK, Geha RS.

J Clin Invest. 1999 Apr;103(8):1103-11.


CD1d restricted natural killer T cells are not required for allergic skin inflammation.

Elkhal A, Pichavant M, He R, Scott J, Meyer E, Goya S, Geha RS, Umetsu DT.

J Allergy Clin Immunol. 2006 Dec;118(6):1363-8. Epub 2006 Sep 25.


Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen.

Oyoshi MK, Murphy GF, Geha RS.

J Allergy Clin Immunol. 2009 Sep;124(3):485-93, 493.e1. doi: 10.1016/j.jaci.2009.05.042. Epub 2009 Aug 8.


Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin.

Oyoshi MK, Elkhal A, Scott JE, Wurbel MA, Hornick JL, Campbell JJ, Geha RS.

J Clin Invest. 2011 Jun;121(6):2210-20. doi: 10.1172/JCI43586. Epub 2011 May 2.


Epicutaneous exposure to staphylococcal superantigen enterotoxin B enhances allergic lung inflammation via an IL-17A dependent mechanism.

Yu J, Oh MH, Park JU, Myers AC, Dong C, Zhu Z, Zheng T.

PLoS One. 2012;7(7):e39032. doi: 10.1371/journal.pone.0039032. Epub 2012 Jul 27.


Oral tolerance inhibits atopic dermatitis-like type 2 inflammation in mice by modulating immune microenvironments.

Baek JO, Roh JY, Jung Y.

Allergy. 2017 Mar;72(3):397-406. doi: 10.1111/all.12960. Epub 2016 Jul 22.


The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen.

Kawamoto S, Yalcindag A, Laouini D, Brodeur S, Bryce P, Lu B, Humbles AA, Oettgen H, Gerard C, Geha RS.

J Clin Invest. 2004 Aug;114(3):399-407.


An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis.

Woodward AL, Spergel JM, Alenius H, Mizoguchi E, Bhan AK, Castigli E, Brodeur SR, Oettgen HC, Geha RS.

J Allergy Clin Immunol. 2001 Feb;107(2):359-66.


Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis.

Oyoshi MK, He R, Kanaoka Y, ElKhal A, Kawamoto S, Lewis CN, Austen KF, Geha RS.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4992-7. doi: 10.1073/pnas.1203127109. Epub 2012 Mar 13.


Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice.

Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S.

J Invest Dermatol. 2016 Jul;136(7):1408-1417. doi: 10.1016/j.jid.2016.02.810. Epub 2016 Mar 14.


Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge.

He R, Oyoshi MK, Jin H, Geha RS.

Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15817-22. Epub 2007 Sep 24.


The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen.

Yalcindag A, He R, Laouini D, Alenius H, Carroll M, Oettgen HC, Geha RS.

J Allergy Clin Immunol. 2006 Jun;117(6):1455-61. Epub 2006 Mar 31.


Repeated epicutaneous exposures to ovalbumin progressively induce atopic dermatitis-like skin lesions in mice.

Wang G, Savinko T, Wolff H, Dieu-Nosjean MC, Kemeny L, Homey B, Lauerma AI, Alenius H.

Clin Exp Allergy. 2007 Jan;37(1):151-61.


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