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Items: 1 to 20 of 142

1.

Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors.

Sazinsky SL, Ott RG, Silver NW, Tidor B, Ravetch JV, Wittrup KD.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20167-72. doi: 10.1073/pnas.0809257105. Epub 2008 Dec 12.

2.

Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs.

Chen TF, Sazinsky SL, Houde D, DiLillo DJ, Bird J, Li KK, Cheng GT, Qiu H, Engen JR, Ravetch JV, Wittrup KD.

J Mol Biol. 2017 Aug 4;429(16):2528-2541. doi: 10.1016/j.jmb.2017.07.001. Epub 2017 Jul 8.

PMID:
28694069
3.

Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells.

Jung ST, Reddy ST, Kang TH, Borrok MJ, Sandlie I, Tucker PW, Georgiou G.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):604-9. doi: 10.1073/pnas.0908590107. Epub 2009 Dec 18.

5.

Structural consequences of aglycosylated IgG Fc variants evolved for FcγRI binding.

Ju MS, Na JH, Yu YG, Kim JY, Jeong C, Jung ST.

Mol Immunol. 2015 Oct;67(2 Pt B):350-6. doi: 10.1016/j.molimm.2015.06.020. Epub 2015 Jul 4.

PMID:
26153451
6.

Molecular aspects of human FcgammaR interactions with IgG: functional and therapeutic consequences.

Sibéril S, Dutertre CA, Boix C, Bonnin E, Ménez R, Stura E, Jorieux S, Fridman WH, Teillaud JL.

Immunol Lett. 2006 Aug 15;106(2):111-8. Epub 2006 Jun 12. Review.

PMID:
16797726
7.

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations.

Vafa O, Gilliland GL, Brezski RJ, Strake B, Wilkinson T, Lacy ER, Scallon B, Teplyakov A, Malia TJ, Strohl WR.

Methods. 2014 Jan 1;65(1):114-26. doi: 10.1016/j.ymeth.2013.06.035. Epub 2013 Jul 17.

PMID:
23872058
8.

A protein structural change in aglycosylated IgG3 correlates with loss of huFc gamma R1 and huFc gamma R111 binding and/or activation.

Lund J, Tanaka T, Takahashi N, Sarmay G, Arata Y, Jefferis R.

Mol Immunol. 1990 Nov;27(11):1145-53.

PMID:
2174119
9.

Avidity confers FcγR binding and immune effector function to aglycosylated immunoglobulin G1.

Nesspor TC, Raju TS, Chin CN, Vafa O, Brezski RJ.

J Mol Recognit. 2012 Mar;25(3):147-54. doi: 10.1002/jmr.2155.

PMID:
22407978
10.

Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity.

Nimmerjahn F, Anthony RM, Ravetch JV.

Proc Natl Acad Sci U S A. 2007 May 15;104(20):8433-7. Epub 2007 May 7.

11.

Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding.

Borrok MJ, Luheshi NM, Beyaz N, Davies GC, Legg JW, Wu H, Dall'Acqua WF, Tsui P.

MAbs. 2015;7(4):743-51. doi: 10.1080/19420862.2015.1047570.

12.

Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation.

Kaneko Y, Nimmerjahn F, Ravetch JV.

Science. 2006 Aug 4;313(5787):670-3.

13.

Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions.

Grevys A, Bern M, Foss S, Bratlie DB, Moen A, Gunnarsen KS, Aase A, Michaelsen TE, Sandlie I, Andersen JT.

J Immunol. 2015 Jun 1;194(11):5497-508. doi: 10.4049/jimmunol.1401218. Epub 2015 Apr 22.

15.

Functional interactions of aglycosylated monoclonal anti-D with Fc gamma RI+ and Fc gamma RIII+ cells.

Leader KA, Kumpel BM, Hadley AG, Bradley BA.

Immunology. 1991 Apr;72(4):481-5.

16.

Glycosylation and Fc receptors.

Hayes JM, Cosgrave EF, Struwe WB, Wormald M, Davey GP, Jefferis R, Rudd PM.

Curr Top Microbiol Immunol. 2014;382:165-99. doi: 10.1007/978-3-319-07911-0_8. Review.

PMID:
25116100
17.

Type I and type II Fc receptors regulate innate and adaptive immunity.

Pincetic A, Bournazos S, DiLillo DJ, Maamary J, Wang TT, Dahan R, Fiebiger BM, Ravetch JV.

Nat Immunol. 2014 Aug;15(8):707-16. doi: 10.1038/ni.2939. Review.

PMID:
25045879
18.

Structural analysis of Fc/FcγR complexes: a blueprint for antibody design.

Caaveiro JM, Kiyoshi M, Tsumoto K.

Immunol Rev. 2015 Nov;268(1):201-21. doi: 10.1111/imr.12365. Review.

PMID:
26497522
19.

Recognition sites on human IgG for Fc gamma receptors: the role of glycosylation.

Jefferis R, Lund J, Goodall M.

Immunol Lett. 1995 Jan;44(2-3):111-7.

PMID:
7797239
20.

Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells.

Carreño LJ, Pacheco R, Gutierrez MA, Jacobelli S, Kalergis AM.

Immunology. 2009 Nov;128(3):334-41. doi: 10.1111/j.1365-2567.2009.03138.x.

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