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Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.

Patwari P, Gao G, Lee JH, Grodzinsky AJ, Sandy JD.

Osteoarthritis Cartilage. 2005 Apr;13(4):269-77.


Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments.

Pratta MA, Su JL, Leesnitzer MA, Struglics A, Larsson S, Lohmander LS, Kumar S.

Osteoarthritis Cartilage. 2006 Jul;14(7):702-13. Epub 2006 Mar 20.


The cleavage of biglycan by aggrecanases.

Melching LI, Fisher WD, Lee ER, Mort JS, Roughley PJ.

Osteoarthritis Cartilage. 2006 Nov;14(11):1147-54. Epub 2006 Jun 30.


A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs.

Swearingen CA, Chambers MG, Lin C, Marimuthu J, Rito CJ, Carter QL, Dotzlaf J, Liu C, Chandrasekhar S, Duffin KL, Mitchell PG, Durham TB, Wiley MR, Thirunavukkarasu K.

Osteoarthritis Cartilage. 2010 Sep;18(9):1159-66. doi: 10.1016/j.joca.2010.02.019. Epub 2010 Jul 13.


Development and characterization of a novel ELISA based assay for the quantitation of sub-nanomolar levels of neoepitope exposed NITEGE-containing aggrecan fragments.

Carter QL, Dotzlaf J, Swearingen C, Brittain I, Chambers M, Duffin K, Mitchell P, Thirunavukkarasu K.

J Immunol Methods. 2007 Dec 1;328(1-2):162-8. Epub 2007 Oct 1.


Image analysis of aggrecan degradation in articular cartilage with formalin-fixed samples.

Osborn B, Bai Y, Plaas AH, Sandy JD.

Methods Mol Med. 2007;135:167-82.


ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.

Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD.

J Biol Chem. 2002 May 3;277(18):16059-66. Epub 2002 Feb 19.


MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.

Struglics A, Hansson M.

Biochem J. 2012 Sep 1;446(2):213-23. doi: 10.1042/BJ20120274.


Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain.

Lark MW, Gordy JT, Weidner JR, Ayala J, Kimura JH, Williams HR, Mumford RA, Flannery CR, Carlson SS, Iwata M, et al.

J Biol Chem. 1995 Feb 10;270(6):2550-6.


Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2.

Lemke AK, Sandy JD, Voigt H, Dreier R, Lee JH, Grodzinsky AJ, Mentlein R, Fay J, Sch√ľnke M, Kurz B.

Cell Tissue Res. 2010 Apr;340(1):179-88. doi: 10.1007/s00441-010-0941-4. Epub 2010 Mar 9.


Matrix metalloproteinase 17 is necessary for cartilage aggrecan degradation in an inflammatory environment.

Clements KM, Flannelly JK, Tart J, Brockbank SM, Wardale J, Freeth J, Parker AE, Newham P.

Ann Rheum Dis. 2011 Apr;70(4):683-9. doi: 10.1136/ard.2010.130757. Epub 2011 Jan 7.


Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage.

Durigova M, Soucy P, Fushimi K, Nagase H, Mort JS, Roughley PJ.

Osteoarthritis Cartilage. 2008 Oct;16(10):1245-52. doi: 10.1016/j.joca.2008.02.013. Epub 2008 Mar 26.


The development and characterization of a competitive ELISA for measuring active ADAMTS-4 in a bovine cartilage ex vivo model.

He Y, Zheng Q, Simonsen O, Petersen KK, Christiansen TG, Karsdal MA, Bay-Jensen AC.

Matrix Biol. 2013 Apr 24;32(3-4):143-51. doi: 10.1016/j.matbio.2012.12.001. Epub 2013 Jan 4.


ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.

Demircan K, Topcu V, Takigawa T, Akyol S, Yonezawa T, Ozturk G, Ugurcu V, Hasgul R, Yigitoglu MR, Akyol O, McCulloch DR, Hirohata S.

Biomed Res Int. 2014;2014:693746. doi: 10.1155/2014/693746. Epub 2014 Jul 3.


Expression of aggrecan(ases) during murine preadipocyte differentiation and adipose tissue development.

Voros G, Sandy JD, Collen D, Lijnen HR.

Biochim Biophys Acta. 2006 Dec;1760(12):1837-44. Epub 2006 Aug 26.


Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine.

Swearingen CA, Carpenter JW, Siegel R, Brittain IJ, Dotzlaf J, Durham TB, Toth JL, Laska DA, Marimuthu J, Liu C, Brown DP, Carter QL, Wiley MR, Duffin KL, Mitchell PG, Thirunavukkarasu K.

Osteoarthritis Cartilage. 2010 Sep;18(9):1150-8. doi: 10.1016/j.joca.2010.06.011. Epub 2010 Jul 13.


Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration.

Patel KP, Sandy JD, Akeda K, Miyamoto K, Chujo T, An HS, Masuda K.

Spine (Phila Pa 1976). 2007 Nov 1;32(23):2596-603.


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