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Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery.

Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin MT 4th, Snyder DC, Owzar K, Hars V, Albala DM, Walther PJ, Robertson CN, Moul JW, Dunn BK, Brenner D, Minasian L, Stella P, Vollmer RT.

Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3577-87. doi: 10.1158/1055-9965.EPI-08-0008.


Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features.

Demark-Wahnefried W, Price DT, Polascik TJ, Robertson CN, Anderson EE, Paulson DF, Walther PJ, Gannon M, Vollmer RT.

Urology. 2001 Jul;58(1):47-52.


Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen.

Demark-Wahnefried W, Robertson CN, Walther PJ, Polascik TJ, Paulson DF, Vollmer RT.

Urology. 2004 May;63(5):900-4.


Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy.

Aronson WJ, Kobayashi N, Barnard RJ, Henning S, Huang M, Jardack PM, Liu B, Gray A, Wan J, Konijeti R, Freedland SJ, Castor B, Heber D, Elashoff D, Said J, Cohen P, Galet C.

Cancer Prev Res (Phila). 2011 Dec;4(12):2062-71. doi: 10.1158/1940-6207.CAPR-11-0298. Epub 2011 Oct 25.


Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer.

Heymach JV, Shackleford TJ, Tran HT, Yoo SY, Do KA, Wergin M, Saintigny P, Vollmer RT, Polascik TJ, Snyder DC, Ruffin MT 4th, Yan S, Dewhirst M, Kunnumakkara AB, Aggarwal BB, Demark-Wahnefried W.

Cancer Prev Res (Phila). 2011 Oct;4(10):1590-8. doi: 10.1158/1940-6207.CAPR-10-0136. Epub 2011 Jul 15.


Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer.

Aronson WJ, Barnard RJ, Freedland SJ, Henning S, Elashoff D, Jardack PM, Cohen P, Heber D, Kobayashi N.

J Urol. 2010 Jan;183(1):345-50. doi: 10.1016/j.juro.2009.08.104.


Disparate results between proliferation rates of surgically excised prostate tumors and an in vitro bioassay using sera from a positive randomized controlled trial.

Azrad M, Vollmer RT, Madden J, Polascik TJ, Snyder DC, Ruffin MT 4th, Moul JW, Brenner D, He X, Demark-Wahnefried W.

Biotech Histochem. 2015 Apr;90(3):184-9. doi: 10.3109/10520295.2014.976840. Epub 2014 Dec 1.


Feasibility of a low-fat/high-fiber diet intervention with soy supplementation in prostate cancer patients after prostatectomy.

Li Z, Aronson WJ, Arteaga JR, Hong K, Thames G, Henning SM, Liu W, Elashoff R, Ashley JM, Heber D.

Eur J Clin Nutr. 2008 Apr;62(4):526-36. Epub 2007 Mar 28.


Dietary intervention strategies to modulate prostate cancer risk and prognosis.

Freedland SJ, Aronson WJ.

Curr Opin Urol. 2009 May;19(3):263-7. doi: 10.1097/MOU.0b013e328329ea6c. Review.


Overcoming challenges in designing and implementing a phase II randomized controlled trial using a presurgical model to test a dietary intervention in prostate cancer.

Demark-Wahnefried W, George SL, Switzer BR, Snyder DC, Madden JF, Polascik TJ, Ruffin MT 4th, Vollmer RT.

Clin Trials. 2008;5(3):262-72. doi: 10.1177/1740774508091676.


Adherence to a low-fat diet in men with prostate cancer.

Link LB, Thompson SM, Bosland MC, Lumey LH.

Urology. 2004 Nov;64(5):970-5.


The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model.

Mavropoulos JC, Buschemeyer WC 3rd, Tewari AK, Rokhfeld D, Pollak M, Zhao Y, Febbo PG, Cohen P, Hwang D, Devi G, Demark-Wahnefried W, Westman EC, Peterson BL, Pizzo SV, Freedland SJ.

Cancer Prev Res (Phila). 2009 Jun;2(6):557-65. doi: 10.1158/1940-6207.CAPR-08-0188. Epub 2009 May 26.


Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice.

Lin X, Gingrich JR, Bao W, Li J, Haroon ZA, Demark-Wahnefried W.

Urology. 2002 Nov;60(5):919-24.


Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis.

Freedland SJ, Mavropoulos J, Wang A, Darshan M, Demark-Wahnefried W, Aronson WJ, Cohen P, Hwang D, Peterson B, Fields T, Pizzo SV, Isaacs WB.

Prostate. 2008 Jan 1;68(1):11-9.


Flaxseed in pediatric hyperlipidemia: a placebo-controlled, blinded, randomized clinical trial of dietary flaxseed supplementation for children and adolescents with hypercholesterolemia.

Wong H, Chahal N, Manlhiot C, Niedra E, McCrindle BW.

JAMA Pediatr. 2013 Aug 1;167(8):708-13. doi: 10.1001/jamapediatrics.2013.1442.


Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial.

Bloedon LT, Balikai S, Chittams J, Cunnane SC, Berlin JA, Rader DJ, Szapary PO.

J Am Coll Nutr. 2008 Feb;27(1):65-74.


Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer.

Dalais FS, Meliala A, Wattanapenpaiboon N, Frydenberg M, Suter DA, Thomson WK, Wahlqvist ML.

Urology. 2004 Sep;64(3):510-5.


Effect of isocaloric low fat diet on prostate cancer xenograft progression in a hormone deprivation model.

Lloyd JC, Antonelli JA, Phillips TE, Masko EM, Thomas JA, Poulton SH, Pollak M, Freedland SJ.

J Urol. 2010 Apr;183(4):1619-24. doi: 10.1016/j.juro.2009.12.003. Epub 2010 Feb 20. Erratum in: J Urol. 2010 Aug;184(2):808. Pollack, Michael [corrected to Pollak, Michael].


Dietary manipulation, ethnicity, and serum PSA levels.

Eastham JA, Riedel E, Latkany L, Fleisher M, Schatzkin A, Lanza E, Shike M; Polyp Prevention Trial Study Group.

Urology. 2003 Oct;62(4):677-82.


Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts.

Venkateswaran V, Haddad AQ, Fleshner NE, Fan R, Sugar LM, Nam R, Klotz LH, Pollak M.

J Natl Cancer Inst. 2007 Dec 5;99(23):1793-800. Epub 2007 Nov 27.


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