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Items: 1 to 20 of 479

1.

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH.

Science. 2008 Dec 19;322(5909):1839-42. doi: 10.1126/science.1165409. Epub 2008 Dec 4.

2.

Binding patterns of BCL11A in the globin and GATA1 loci and characterization of the BCL11A fetal hemoglobin locus.

Jawaid K, Wahlberg K, Thein SL, Best S.

Blood Cells Mol Dis. 2010 Aug 15;45(2):140-6. doi: 10.1016/j.bcmd.2010.05.006. Epub 2010 Jun 12.

PMID:
20542454
3.

Developmental biology. From genetic association to genetic switch.

Michelson AM.

Science. 2008 Dec 19;322(5909):1803-4. doi: 10.1126/science.1169216. No abstract available.

PMID:
19095932
4.

Transcriptional silencing of fetal hemoglobin by BCL11A.

Sankaran VG, Xu J, Orkin SH.

Ann N Y Acad Sci. 2010 Aug;1202:64-8. doi: 10.1111/j.1749-6632.2010.05574.x.

PMID:
20712774
5.

Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line.

Zein S, Li W, Ramakrishnan V, Lou TF, Sivanand S, Mackie A, Pace B.

Exp Biol Med (Maywood). 2010 Nov;235(11):1385-94. doi: 10.1258/ebm.2010.010129.

PMID:
20975082
6.

MicroRNA-486-3p regulates γ-globin expression in human erythroid cells by directly modulating BCL11A.

Lulli V, Romania P, Morsilli O, Cianciulli P, Gabbianelli M, Testa U, Giuliani A, Marziali G.

PLoS One. 2013 Apr 4;8(4):e60436. doi: 10.1371/journal.pone.0060436. Print 2013.

7.

Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal β-like globin genes.

Roosjen M, McColl B, Kao B, Gearing LJ, Blewitt ME, Vadolas J.

FASEB J. 2014 Apr;28(4):1610-20. doi: 10.1096/fj.13-242669. Epub 2013 Dec 26.

8.

[BCL11A represses HbF expression and varies during ontogeny].

Labie D.

Med Sci (Paris). 2009 May;25(5):457-60. doi: 10.1051/medsci/2009255457. French. No abstract available.

9.

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.

Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6518-23. doi: 10.1073/pnas.1303976110. Epub 2013 Apr 1.

10.

[BCL11A controls the expression of the human fetal hemoglobin].

Labie D.

Med Sci (Paris). 2012 Nov;28(11):923-5. doi: 10.1051/medsci/20122811007. Epub 2012 Nov 12. French. No abstract available.

11.

Hemoglobin switching in humans is accompanied by changes in the ratio of the transcription factors, GATA-1 and SP1.

Bacon ER, Dalyot N, Filon D, Schreiber L, Rachmilewitz EA, Oppenheim A.

Mol Med. 1995 Mar;1(3):297-305.

12.

The XmnI (G)gamma polymorphism influences hemoglobin F synthesis contrary to BCL11A and HBS1L-MYB SNPs in a cohort of 57 beta-thalassemia intermedia patients.

Nguyen TK, Joly P, Bardel C, Moulsma M, Bonello-Palot N, Francina A.

Blood Cells Mol Dis. 2010 Aug 15;45(2):124-7. doi: 10.1016/j.bcmd.2010.04.002. Epub 2010 May 15.

PMID:
20472475
13.

BCL11A represses HBG transcription in K562 cells.

Chen Z, Luo HY, Steinberg MH, Chui DH.

Blood Cells Mol Dis. 2009 Mar-Apr;42(2):144-9. doi: 10.1016/j.bcmd.2008.12.003. Epub 2009 Jan 18.

PMID:
19153051
14.

Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model.

Spyrou P, Phylactides M, Lederer CW, Kithreotis L, Kirri A, Christou S, Kkolou E, Kanavakis E, Anagnou NP, Stamatoyannopoulos G, Kleanthous M.

Blood Cells Mol Dis. 2010 Mar-Apr;44(2):100-6. doi: 10.1016/j.bcmd.2009.10.008. Epub 2009 Nov 14.

PMID:
19914848
15.

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.

Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, Crossley M, Bauer DE, Orkin SH, Kharchenko PV, Maeda T.

Science. 2016 Jan 15;351(6270):285-9. doi: 10.1126/science.aad3312.

16.

Role of intergenic human gamma-delta-globin sequences in human hemoglobin switching and reactivation of fetal hemoglobin in adult erythroid cells.

Bank A, O'Neill D, Lopez R, Pulte D, Ward M, Mantha S, Richardson C.

Ann N Y Acad Sci. 2005;1054:48-54. Review.

PMID:
16339651
17.

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.

Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, Stamatoyannopoulos JA, Lettre G, Orkin SH.

Science. 2013 Oct 11;342(6155):253-7. doi: 10.1126/science.1242088.

18.

Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms.

Chin J, Singh M, Banzon V, Vaitkus K, Ibanez V, Kouznetsova T, Mahmud N, DeSimone J, Lavelle D.

Exp Hematol. 2009 Oct;37(10):1131-42. doi: 10.1016/j.exphem.2009.06.007. Epub 2009 Jul 2.

PMID:
19576949
19.

Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development.

McConnell SC, Huo Y, Liu S, Ryan TM.

Mol Cell Biol. 2011 Feb;31(4):876-83. doi: 10.1128/MCB.00725-10. Epub 2010 Dec 20.

20.

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