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Items: 1 to 20 of 204

1.

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.

Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19384-9. doi: 10.1073/pnas.0810584105. Epub 2008 Dec 3.

2.

mTORC1 signaling governs hematopoietic stem cell quiescence.

Gan B, DePinho RA.

Cell Cycle. 2009 Apr 1;8(7):1003-6. Epub 2009 Apr 2.

3.

Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.

Wolff NC, Vega-Rubin-de-Celis S, Xie XJ, Castrillon DH, Kabbani W, Brugarolas J.

Mol Cell Biol. 2011 May;31(9):1870-84. doi: 10.1128/MCB.01393-10. Epub 2011 Mar 7.

4.

Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin.

Malhowski AJ, Hira H, Bashiruddin S, Warburton R, Goto J, Robert B, Kwiatkowski DJ, Finlay GA.

Hum Mol Genet. 2011 Apr 1;20(7):1290-305. doi: 10.1093/hmg/ddq570. Epub 2011 Jan 6.

5.

Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.

Huang J, Wu S, Wu CL, Manning BD.

Cancer Res. 2009 Aug 1;69(15):6107-14. doi: 10.1158/0008-5472.CAN-09-0975. Epub 2009 Jul 14.

6.

Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals.

Yamada D, Hoshii T, Tanaka S, Hegazy AM, Kobayashi M, Tadokoro Y, Ohta K, Ueno M, Ali MA, Hirao A.

J Biochem. 2014 Apr;155(4):227-33. doi: 10.1093/jb/mvt112. Epub 2013 Dec 23.

PMID:
24368778
7.

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD.

PLoS One. 2009 Jul 10;4(7):e6189. doi: 10.1371/journal.pone.0006189.

8.

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.

Huang J, Dibble CC, Matsuzaki M, Manning BD.

Mol Cell Biol. 2008 Jun;28(12):4104-15. doi: 10.1128/MCB.00289-08. Epub 2008 Apr 14.

9.

MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer.

Chen MB, Wei MX, Han JY, Wu XY, Li C, Wang J, Shen W, Lu PH.

Cell Signal. 2014 Jan;26(1):102-9. doi: 10.1016/j.cellsig.2013.07.017. Epub 2013 Jul 27.

PMID:
23899558
10.

Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.

Bilanges B, Argonza-Barrett R, Kolesnichenko M, Skinner C, Nair M, Chen M, Stokoe D.

Mol Cell Biol. 2007 Aug;27(16):5746-64. Epub 2007 Jun 11.

11.

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.

Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, Manning BD.

Mol Cell. 2012 Aug 24;47(4):535-46. doi: 10.1016/j.molcel.2012.06.009. Epub 2012 Jul 12.

12.

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.

Huang J, Manning BD.

Biochem J. 2008 Jun 1;412(2):179-90. doi: 10.1042/BJ20080281. Review.

13.

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species.

Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y, Zheng P.

J Exp Med. 2008 Sep 29;205(10):2397-408. doi: 10.1084/jem.20081297. Epub 2008 Sep 22.

14.

Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts.

Goncharova EA, James ML, Kudryashova TV, Goncharov DA, Krymskaya VP.

PLoS One. 2014 Oct 31;9(10):e111476. doi: 10.1371/journal.pone.0111476. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0118637.

15.

Regulation of T-cell survival and mitochondrial homeostasis by TSC1.

O'Brien TF, Gorentla BK, Xie D, Srivatsan S, McLeod IX, He YW, Zhong XP.

Eur J Immunol. 2011 Nov;41(11):3361-70. doi: 10.1002/eji.201141411. Epub 2011 Sep 19.

16.

Complex Neurological Phenotype in Mutant Mice Lacking Tsc2 in Excitatory Neurons of the Developing Forebrain(123).

Crowell B, Lee GH, Nikolaeva I, Dal Pozzo V, D'Arcangelo G.

eNeuro. 2015 Oct 22;2(6). pii: ENEURO.0046-15.2015. doi: 10.1523/ENEURO.0046-15.2015. eCollection 2015 Nov-Dec.

17.

Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs.

Shrestha S, Yang K, Wei J, Karmaus PW, Neale G, Chi H.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14858-63. doi: 10.1073/pnas.1404264111. Epub 2014 Sep 30.

18.

A complex interplay between PGC-1 co-activators and mTORC1 regulates hematopoietic recovery following 5-fluorouracil treatment.

Basu S.

Stem Cell Res. 2014 Jan;12(1):178-93. doi: 10.1016/j.scr.2013.10.006. Epub 2013 Oct 24.

19.

Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules.

Armour EA, Carson RP, Ess KC.

Am J Physiol Renal Physiol. 2012 Aug 15;303(4):F584-92. doi: 10.1152/ajprenal.00141.2012. Epub 2012 Jun 6.

20.

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21.

Cornu M, Oppliger W, Albert V, Robitaille AM, Trapani F, Quagliata L, Fuhrer T, Sauer U, Terracciano L, Hall MN.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11592-9. doi: 10.1073/pnas.1412047111. Epub 2014 Jul 31.

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