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Items: 1 to 20 of 101

1.

Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

Yu L, Lopez A, Anaflous A, El Bali B, Hamal A, Ericson E, Heisler LE, McQuibban A, Giaever G, Nislow C, Boone C, Brown GW, Bellaoui M.

PLoS Genet. 2008 Nov;4(11):e1000284. doi: 10.1371/journal.pgen.1000284. Epub 2008 Nov 28.

2.

Synthesis and biological evaluation of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines as new inhibitors of the Wnt/β-catenin signaling.

Cosimelli B, Laneri S, Ostacolo C, Sacchi A, Severi E, Porcù E, Rampazzo E, Moro E, Basso G, Viola G.

Eur J Med Chem. 2014 Aug 18;83:45-56. doi: 10.1016/j.ejmech.2014.05.071. Epub 2014 Jun 6.

PMID:
24950489
3.

Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.

Fauber BP, Gobbi A, Robarge K, Zhou A, Barnard A, Cao J, Deng Y, Eidenschenk C, Everett C, Ganguli A, Hawkins J, Johnson AR, La H, Norman M, Salmon G, Summerhill S, Ouyang W, Tang W, Wong H.

Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12. doi: 10.1016/j.bmcl.2015.05.055. Epub 2015 May 28.

PMID:
26048793
4.

Scaffold-switching: an exploration of 5,6-fused bicyclic heteroaromatics systems to afford antituberculosis activity akin to the imidazo[1,2-a]pyridine-3-carboxylates.

Moraski GC, Oliver AG, Markley LD, Cho S, Franzblau SG, Miller MJ.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3493-8. doi: 10.1016/j.bmcl.2014.05.062. Epub 2014 May 28.

5.

Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents.

Richie DL, Thompson KV, Studer C, Prindle VC, Aust T, Riedl R, Estoppey D, Tao J, Sexton JA, Zabawa T, Drumm J, Cotesta S, Eichenberger J, Schuierer S, Hartmann N, Movva NR, Tallarico JA, Ryder NS, Hoepfner D.

Antimicrob Agents Chemother. 2013 May;57(5):2272-80. doi: 10.1128/AAC.01809-12. Epub 2013 Mar 11.

6.

Imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyrazines: the role of nitrogen position in inotropic activity.

Spitzer WA, Victor F, Pollock GD, Hayes JS.

J Med Chem. 1988 Aug;31(8):1590-5.

PMID:
3397997
7.

The novel equisetin-like compound, TA-289, causes aberrant mitochondrial morphology which is independent of the production of reactive oxygen species in Saccharomyces cerevisiae.

Quek NC, Matthews JH, Bloor SJ, Jones DA, Bircham PW, Heathcott RW, Atkinson PH.

Mol Biosyst. 2013 Aug;9(8):2125-33. doi: 10.1039/c3mb70056a. Epub 2013 May 28.

PMID:
23715404
8.

Chemical proteomic analysis reveals alternative modes of action for pyrido[2,3-d]pyrimidine kinase inhibitors.

Wissing J, Godl K, Brehmer D, Blencke S, Weber M, Habenberger P, Stein-Gerlach M, Missio A, Cotten M, Müller S, Daub H.

Mol Cell Proteomics. 2004 Dec;3(12):1181-93. Epub 2004 Oct 8.

9.

Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action.

Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ.

Mol Syst Biol. 2010 Dec 21;6:451. doi: 10.1038/msb.2010.107.

10.

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.

Hoepfner D, Helliwell SB, Sadlish H, Schuierer S, Filipuzzi I, Brachat S, Bhullar B, Plikat U, Abraham Y, Altorfer M, Aust T, Baeriswyl L, Cerino R, Chang L, Estoppey D, Eichenberger J, Frederiksen M, Hartmann N, Hohendahl A, Knapp B, Krastel P, Melin N, Nigsch F, Oakeley EJ, Petitjean V, Petersen F, Riedl R, Schmitt EK, Staedtler F, Studer C, Tallarico JA, Wetzel S, Fishman MC, Porter JA, Movva NR.

Microbiol Res. 2014 Feb-Mar;169(2-3):107-20. doi: 10.1016/j.micres.2013.11.004. Epub 2013 Dec 1.

11.

In vitro anti-Giardia lamblia activity of 2-aryl-3-hydroxymethyl imidazo[1,2-a]pyridines and -pyrimidines, individually and in combination with albendazole.

Velázquez-Olvera S, Salgado-Zamora H, Jiménez-Cardoso E, Campos-Aldrete ME, Pérez-González C, Ben Hadda T.

Acta Trop. 2016 Mar;155:6-10. doi: 10.1016/j.actatropica.2015.11.013. Epub 2015 Dec 3.

PMID:
26657313
12.

Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.

Gueiffier A, Lhassani M, Elhakmaoui A, Snoeck R, Andrei G, Chavignon O, Teulade JC, Kerbal A, Essassi EM, Debouzy JC, Witvrouw M, Blache Y, Balzarini J, De Clercq E, Chapat JP.

J Med Chem. 1996 Jul 5;39(14):2856-9.

PMID:
8709116
13.

Post Groebke-Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents.

Al-Tel TH, Al-Qawasmeh RA.

Eur J Med Chem. 2010 Dec;45(12):5848-55. doi: 10.1016/j.ejmech.2010.09.049. Epub 2010 Sep 25.

PMID:
20934788
14.

Chemical-genetic approaches for exploring the mode of action of natural products.

Lopez A, Parsons AB, Nislow C, Giaever G, Boone C.

Prog Drug Res. 2008;66:237, 239-71. Review.

PMID:
18416308
15.

Tandem [8 + 2] cycloaddition--[2 + 6 + 2] dehydrogenation reactions involving imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines.

Aginagalde M, Vara Y, Arrieta A, Zangi R, Cebolla VL, Delgado-Camón A, Cossío FP.

J Org Chem. 2010 May 7;75(9):2776-84. doi: 10.1021/jo9022815.

PMID:
19921806
16.

Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae.

Agarwal AK, Rogers PD, Baerson SR, Jacob MR, Barker KS, Cleary JD, Walker LA, Nagle DG, Clark AM.

J Biol Chem. 2003 Sep 12;278(37):34998-5015. Epub 2003 Jun 24.

17.

Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives.

Gamal-Eldeen AM, Hamdy NA, Abdel-Aziz HA, El-Hussieny EA, Fakhr IM.

Eur J Med Chem. 2014 Apr 22;77:323-33. doi: 10.1016/j.ejmech.2014.03.021. Epub 2014 Mar 12.

PMID:
24657569
18.

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast.

Giaever G, Flaherty P, Kumm J, Proctor M, Nislow C, Jaramillo DF, Chu AM, Jordan MI, Arkin AP, Davis RW.

Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):793-8. Epub 2004 Jan 12.

19.

Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs.

Al-Tel TH, Al-Qawasmeh RA, Zaarour R.

Eur J Med Chem. 2011 May;46(5):1874-81. doi: 10.1016/j.ejmech.2011.02.051. Epub 2011 Feb 26.

PMID:
21414694
20.

5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV.

Starr JT, Sciotti RJ, Hanna DL, Huband MD, Mullins LM, Cai H, Gage JW, Lockard M, Rauckhorst MR, Owen RM, Lall MS, Tomilo M, Chen H, McCurdy SP, Barbachyn MR.

Bioorg Med Chem Lett. 2009 Sep 15;19(18):5302-6. doi: 10.1016/j.bmcl.2009.07.141. Epub 2009 Aug 3.

PMID:
19683922

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