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Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells.

Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH.

Cell Stem Cell. 2008 Dec 4;3(6):649-57. doi: 10.1016/j.stem.2008.10.001.


Transcriptional profile of primary astrocytes expressing ALS-linked mutant SOD1.

Vargas MR, Pehar M, Díaz-Amarilla PJ, Beckman JS, Barbeito L.

J Neurosci Res. 2008 Dec;86(16):3515-25. doi: 10.1002/jnr.21797.


Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.

Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S.

Nat Neurosci. 2007 May;10(5):615-22. Epub 2007 Apr 15.


Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation.

Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC.

Cell Stem Cell. 2008 Dec 4;3(6):637-48. doi: 10.1016/j.stem.2008.09.017.


ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells.

Hedlund E, Isacson O.

Cell Stem Cell. 2008 Dec 4;3(6):575-6. doi: 10.1016/j.stem.2008.11.004. Review.


Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS.

Karumbayaram S, Kelly TK, Paucar AA, Roe AJ, Umbach JA, Charles A, Goldman SA, Kornblum HI, Wiedau-Pazos M.

Dis Model Mech. 2009 Mar-Apr;2(3-4):189-95. doi: 10.1242/dmm.002113. Epub 2009 Feb 23.


Wild-type but not mutant SOD1 transgenic astrocytes promote the efficient generation of motor neuron progenitors from mouse embryonic stem cells.

Christou YA, Ohyama K, Placzek M, Monk PN, Shaw PJ.

BMC Neurosci. 2013 Oct 17;14:126. doi: 10.1186/1471-2202-14-126.


Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants.

Cassina P, Cassina A, Pehar M, Castellanos R, Gandelman M, de León A, Robinson KM, Mason RP, Beckman JS, Barbeito L, Radi R.

J Neurosci. 2008 Apr 16;28(16):4115-22. doi: 10.1523/JNEUROSCI.5308-07.2008.


Enhancing NAD+ Salvage Pathway Reverts the Toxicity of Primary Astrocytes Expressing Amyotrophic Lateral Sclerosis-linked Mutant Superoxide Dismutase 1 (SOD1).

Harlan BA, Pehar M, Sharma DR, Beeson G, Beeson CC, Vargas MR.

J Biol Chem. 2016 May 13;291(20):10836-46. doi: 10.1074/jbc.M115.698779. Epub 2016 Mar 21.


Mutant SOD1-induced neuronal toxicity is mediated by increased mitochondrial superoxide levels.

Zimmerman MC, Oberley LW, Flanagan SW.

J Neurochem. 2007 Aug;102(3):609-18. Epub 2007 Mar 23.


Astrocytes from familial and sporadic ALS patients are toxic to motor neurons.

Haidet-Phillips AM, Hester ME, Miranda CJ, Meyer K, Braun L, Frakes A, Song S, Likhite S, Murtha MJ, Foust KD, Rao M, Eagle A, Kammesheidt A, Christensen A, Mendell JR, Burghes AH, Kaspar BK.

Nat Biotechnol. 2011 Aug 10;29(9):824-8. doi: 10.1038/nbt.1957.


Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress.

Cookson MR, Menzies FM, Manning P, Eggett CJ, Figlewicz DA, McNeil CJ, Shaw PJ.

Amyotroph Lateral Scler Other Motor Neuron Disord. 2002 Jun;3(2):75-85.


GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS.

Suzuki M, McHugh J, Tork C, Shelley B, Klein SM, Aebischer P, Svendsen CN.

PLoS One. 2007 Aug 1;2(8):e689.


Mitochondria-targeted catalase reverts the neurotoxicity of hSOD1G⁹³A astrocytes without extending the survival of ALS-linked mutant hSOD1 mice.

Pehar M, Beeson G, Beeson CC, Johnson JA, Vargas MR.

PLoS One. 2014 Jul 23;9(7):e103438. doi: 10.1371/journal.pone.0103438. eCollection 2014.


Amyotrophic lateral sclerosis model derived from human embryonic stem cells overexpressing mutant superoxide dismutase 1.

Wada T, Goparaju SK, Tooi N, Inoue H, Takahashi R, Nakatsuji N, Aiba K.

Stem Cells Transl Med. 2012 May;1(5):396-402. doi: 10.5966/sctm.2011-0061. Epub 2012 May 8.


Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS.

Kunze A, Lengacher S, Dirren E, Aebischer P, Magistretti PJ, Renaud P.

Integr Biol (Camb). 2013 Jul 24;5(7):964-75. doi: 10.1039/c3ib40022k. Epub 2013 May 22.


Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1.

Boillée S, Cleveland DW.

J Clin Invest. 2008 Feb;118(2):474-8. doi: 10.1172/JCI34613.


Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA.

Wang J, Xu G, Slunt HH, Gonzales V, Coonfield M, Fromholt D, Copeland NG, Jenkins NA, Borchelt DR.

Neurobiol Dis. 2005 Dec;20(3):943-52. Epub 2005 Jul 19.


Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1.

Bruijn LI, Houseweart MK, Kato S, Anderson KL, Anderson SD, Ohama E, Reaume AG, Scott RW, Cleveland DW.

Science. 1998 Sep 18;281(5384):1851-4.

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