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Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation.

Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC.

Cell Stem Cell. 2008 Dec 4;3(6):637-48. doi: 10.1016/j.stem.2008.09.017.


Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells.

Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH.

Cell Stem Cell. 2008 Dec 4;3(6):649-57. doi: 10.1016/j.stem.2008.10.001.


ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells.

Hedlund E, Isacson O.

Cell Stem Cell. 2008 Dec 4;3(6):575-6. doi: 10.1016/j.stem.2008.11.004. Review.


Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model.

Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K.

Nat Neurosci. 2007 May;10(5):608-14.


Human TDP-43 and FUS selectively affect motor neuron maturation and survival in a murine cell model of ALS by non-cell-autonomous mechanisms.

Wächter N, Storch A, Hermann A.

Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(7-8):431-41. doi: 10.3109/21678421.2015.1055275.


GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis.

Carunchio I, Mollinari C, Pieri M, Merlo D, Zona C.

Eur J Neurosci. 2008 Oct;28(7):1275-85. doi: 10.1111/j.1460-9568.2008.06436.x.


Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS.

Karumbayaram S, Kelly TK, Paucar AA, Roe AJ, Umbach JA, Charles A, Goldman SA, Kornblum HI, Wiedau-Pazos M.

Dis Model Mech. 2009 Mar-Apr;2(3-4):189-95. doi: 10.1242/dmm.002113.


Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.

Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S.

Nat Neurosci. 2007 May;10(5):615-22.


Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS.

Robertson J, Sanelli T, Xiao S, Yang W, Horne P, Hammond R, Pioro EP, Strong MJ.

Neurosci Lett. 2007 Jun 13;420(2):128-32.


Astrocytes from familial and sporadic ALS patients are toxic to motor neurons.

Haidet-Phillips AM, Hester ME, Miranda CJ, Meyer K, Braun L, Frakes A, Song S, Likhite S, Murtha MJ, Foust KD, Rao M, Eagle A, Kammesheidt A, Christensen A, Mendell JR, Burghes AH, Kaspar BK.

Nat Biotechnol. 2011 Aug 10;29(9):824-8. doi: 10.1038/nbt.1957.


Transcriptional profile of primary astrocytes expressing ALS-linked mutant SOD1.

Vargas MR, Pehar M, Díaz-Amarilla PJ, Beckman JS, Barbeito L.

J Neurosci Res. 2008 Dec;86(16):3515-25. doi: 10.1002/jnr.21797.


Wild-type but not mutant SOD1 transgenic astrocytes promote the efficient generation of motor neuron progenitors from mouse embryonic stem cells.

Christou YA, Ohyama K, Placzek M, Monk PN, Shaw PJ.

BMC Neurosci. 2013 Oct 17;14:126. doi: 10.1186/1471-2202-14-126.


Modeling amyotrophic lateral sclerosis in pure human iPSc-derived motor neurons isolated by a novel FACS double selection technique.

Toli D, Buttigieg D, Blanchard S, Lemonnier T, Lamotte d'Incamps B, Bellouze S, Baillat G, Bohl D, Haase G.

Neurobiol Dis. 2015 Oct;82:269-80. doi: 10.1016/j.nbd.2015.06.011.


A potential role for the p75 low-affinity neurotrophin receptor in spinal motor neuron degeneration in murine and human amyotrophic lateral sclerosis.

Lowry KS, Murray SS, McLean CA, Talman P, Mathers S, Lopes EC, Cheema SS.

Amyotroph Lateral Scler Other Motor Neuron Disord. 2001 Sep;2(3):127-34.


Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis.

Kirby J, Ning K, Ferraiuolo L, Heath PR, Ismail A, Kuo SW, Valori CF, Cox L, Sharrack B, Wharton SB, Ince PG, Shaw PJ, Azzouz M.

Brain. 2011 Feb;134(Pt 2):506-17. doi: 10.1093/brain/awq345.


Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS.

Suzuki M, McHugh J, Tork C, Shelley B, Hayes A, Bellantuono I, Aebischer P, Svendsen CN.

Mol Ther. 2008 Dec;16(12):2002-10. doi: 10.1038/mt.2008.197.


Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.

Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K.

Science. 2008 Aug 29;321(5893):1218-21. doi: 10.1126/science.1158799.


Induction of polysialic acid-neural cell adhesion molecule in surviving motoneurons of transgenic amyotrophic lateral sclerosis mice.

Warita H, Murakami T, Manabe Y, Sato K, Hayashi T, Seki T, Abe K.

Neurosci Lett. 2001 Mar 9;300(2):75-8.


DJ-1 forms complexes with mutant SOD1 and ameliorates its toxicity.

Yamashita S, Mori A, Kimura E, Mita S, Maeda Y, Hirano T, Uchino M.

J Neurochem. 2010 May;113(4):860-70. doi: 10.1111/j.1471-4159.2010.06658.x.

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