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Items: 1 to 20 of 71


A two-step pathway to resist fasting.

Kaestner KH.

Cell Metab. 2008 Dec;8(6):449-51. doi: 10.1016/j.cmet.2008.11.003.


A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J 3rd, Olefsky J, Guarente L, Montminy M.

Nature. 2008 Nov 13;456(7219):269-73. doi: 10.1038/nature07349. Epub 2008 Oct 5.


Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.

Zhang P, Tu B, Wang H, Cao Z, Tang M, Zhang C, Gu B, Li Z, Wang L, Yang Y, Zhao Y, Wang H, Luo J, Deng CX, Gao B, Roeder RG, Zhu WG.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10684-9. doi: 10.1073/pnas.1411026111. Epub 2014 Jul 9.


High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway.

Mortuza R, Chen S, Feng B, Sen S, Chakrabarti S.

PLoS One. 2013;8(1):e54514. doi: 10.1371/journal.pone.0054514. Epub 2013 Jan 16.


PCAF represses transactivation function of FOXO1 in an acetyltransferase-independent manner.

Yoshimochi K, Daitoku H, Fukamizu A.

J Recept Signal Transduct Res. 2010 Feb;30(1):43-9. doi: 10.3109/10799890903517947.


Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.

Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM.

Nature. 2003 May 29;423(6939):550-5. Epub 2003 May 18.


Reply to Leithner et al.: Focus on phopshoenolpyruvate carboxykinase (PEPCK): a target of the p53-SIRT6-FoxO1 axis.

Li Z, Zhu WG.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4395. doi: 10.1073/pnas.1416664111. Epub 2014 Sep 26. No abstract available.


Gluconeogenesis in cancer: door wide open.

Leithner K, Hrzenjak A, Olschewski H.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4394. doi: 10.1073/pnas.1415680111. Epub 2014 Sep 26. No abstract available.


An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity.

Stankovic-Valentin N, Deltour S, Seeler J, Pinte S, Vergoten G, Guérardel C, Dejean A, Leprince D.

Mol Cell Biol. 2007 Apr;27(7):2661-75. Epub 2007 Feb 5.


Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice.

Altomonte J, Richter A, Harbaran S, Suriawinata J, Nakae J, Thung SN, Meseck M, Accili D, Dong H.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E718-28. Epub 2003 Jun 3.


The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity.

Nakae J, Cao Y, Daitoku H, Fukamizu A, Ogawa W, Yano Y, Hayashi Y.

J Clin Invest. 2006 Sep;116(9):2473-83. Epub 2006 Aug 17.


Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.

Yang Y, Hou H, Haller EM, Nicosia SV, Bai W.

EMBO J. 2005 Mar 9;24(5):1021-32. Epub 2005 Feb 3.


Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.

Yamagata K, Daitoku H, Shimamoto Y, Matsuzaki H, Hirota K, Ishida J, Fukamizu A.

J Biol Chem. 2004 May 28;279(22):23158-65. Epub 2004 Mar 26.


The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis.

Wang Y, Vera L, Fischer WH, Montminy M.

Nature. 2009 Jul 23;460(7254):534-7. doi: 10.1038/nature08111. Epub 2009 Jun 21.


Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.

Caton PW, Nayuni NK, Kieswich J, Khan NQ, Yaqoob MM, Corder R.

J Endocrinol. 2010 Apr;205(1):97-106. doi: 10.1677/JOE-09-0345. Epub 2010 Jan 21.


Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction.

Al-Regaiey KA, Masternak MM, Bonkowski M, Sun L, Bartke A.

Endocrinology. 2005 Feb;146(2):851-60. Epub 2004 Oct 21.


Mammalian SIRT1 represses forkhead transcription factors.

Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L.

Cell. 2004 Feb 20;116(4):551-63.


The role of transcriptional regulators in central control of appetite and body weight.

Coppari R, Ramadori G, Elmquist JK.

Nat Clin Pract Endocrinol Metab. 2009 Mar;5(3):160-6. doi: 10.1038/ncpendmet1070. Review.


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