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Items: 1 to 20 of 123


Chromatin adaptor Brd4 modulates E2 transcription activity and protein stability.

Lee AY, Chiang CM.

J Biol Chem. 2009 Jan 30;284(5):2778-86. doi: 10.1074/jbc.M805835200. Epub 2008 Nov 26.


Brd4 links chromatin targeting to HPV transcriptional silencing.

Wu SY, Lee AY, Hou SY, Kemper JK, Erdjument-Bromage H, Tempst P, Chiang CM.

Genes Dev. 2006 Sep 1;20(17):2383-96. Epub 2006 Aug 18.


The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation.

Wu SY, Chiang CM.

J Biol Chem. 2007 May 4;282(18):13141-5. Epub 2007 Feb 28. Review.


Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4.

Gagnon D, Joubert S, Sénéchal H, Fradet-Turcotte A, Torre S, Archambault J.

J Virol. 2009 May;83(9):4127-39. doi: 10.1128/JVI.02468-08. Epub 2009 Feb 11.


Brd4-mediated nuclear retention of the papillomavirus E2 protein contributes to its stabilization in host cells.

Li J, Li Q, Diaz J, You J.

Viruses. 2014 Jan 20;6(1):319-35. doi: 10.3390/v6010319.


Transcriptional activity among high and low risk human papillomavirus E2 proteins correlates with E2 DNA binding.

Hou SY, Wu SY, Chiang CM.

J Biol Chem. 2002 Nov 22;277(47):45619-29. Epub 2002 Sep 17.


Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses.

McPhillips MG, Oliveira JG, Spindler JE, Mitra R, McBride AA.

J Virol. 2006 Oct;80(19):9530-43.


Analysis of the papillomavirus E2 and bromodomain protein Brd4 interaction using bimolecular fluorescence complementation.

Helfer CM, Wang R, You J.

PLoS One. 2013 Oct 25;8(10):e77994. doi: 10.1371/journal.pone.0077994. eCollection 2013.


Brd4 regulation of papillomavirus protein E2 stability.

Zheng G, Schweiger MR, Martinez-Noel G, Zheng L, Smith JA, Harper JW, Howley PM.

J Virol. 2009 Sep;83(17):8683-92. doi: 10.1128/JVI.00674-09. Epub 2009 Jun 24.


Papillomavirus E2 proteins and the host BRD4 protein associate with transcriptionally active cellular chromatin.

Jang MK, Kwon D, McBride AA.

J Virol. 2009 Mar;83(6):2592-600. doi: 10.1128/JVI.02275-08. Epub 2009 Jan 7.


Brd4-independent transcriptional repression function of the papillomavirus e2 proteins.

Schweiger MR, Ottinger M, You J, Howley PM.

J Virol. 2007 Sep;81(18):9612-22. Epub 2007 Jul 11.


The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis.

Dey A, Chitsaz F, Abbasi A, Misteli T, Ozato K.

Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8758-63. Epub 2003 Jul 2.


Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA.

Wang X, Helfer CM, Pancholi N, Bradner JE, You J.

J Virol. 2013 Apr;87(7):3871-84. doi: 10.1128/JVI.03068-12. Epub 2013 Jan 30.


trans activation by the full-length E2 proteins of human papillomavirus type 16 and bovine papillomavirus type 1 in vitro and in vivo: cooperation with activation domains of cellular transcription factors.

Ushikai M, Lace MJ, Yamakawa Y, Kono M, Anson J, Ishiji T, Parkkinen S, Wicker N, Valentine ME, Davidson I, et al.

J Virol. 1994 Oct;68(10):6655-66.


Dimerization of the papillomavirus E2 protein is required for efficient mitotic chromosome association and Brd4 binding.

Cardenas-Mora J, Spindler JE, Jang MK, McBride AA.

J Virol. 2008 Aug;82(15):7298-305. doi: 10.1128/JVI.00772-08. Epub 2008 May 21.


Phosphorylation of HPV-16 E2 at serine 243 enables binding to Brd4 and mitotic chromosomes.

Chang SW, Liu WC, Liao KY, Tsao YP, Hsu PH, Chen SL.

PLoS One. 2014 Oct 23;9(10):e110882. doi: 10.1371/journal.pone.0110882. eCollection 2014.

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