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Items: 1 to 20 of 100

1.

Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Sidique S, Ardecky R, Su Y, Narisawa S, Brown B, Millán JL, Sergienko E, Cosford ND.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):222-5. doi: 10.1016/j.bmcl.2008.10.107. Epub 2008 Oct 31.

2.

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Dahl R, Sergienko EA, Su Y, Mostofi YS, Yang L, Simao AM, Narisawa S, Brown B, Mangravita-Novo A, Vicchiarelli M, Smith LH, O'Neill WC, Millán JL, Cosford ND.

J Med Chem. 2009 Nov 12;52(21):6919-25. doi: 10.1021/jm900383s.

3.

Inhibitors of tissue-nonspecific alkaline phosphatase: design, synthesis, kinetics, biomineralization and cellular tests.

Debray J, Chang L, Marquès S, Pellet-Rostaing S, Le Duy D, Mebarek S, Buchet R, Magne D, Popowycz F, Lemaire M.

Bioorg Med Chem. 2013 Dec 15;21(24):7981-7. doi: 10.1016/j.bmc.2013.09.053. Epub 2013 Oct 17.

PMID:
24183741
4.

Inhibitors of tissue-nonspecific alkaline phosphatase (TNAP): from hits to leads.

Teriete P, Pinkerton AB, Cosford ND.

Methods Mol Biol. 2013;1053:85-101. doi: 10.1007/978-1-62703-562-0_5.

PMID:
23860648
5.
6.

Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action.

Sergienko E, Su Y, Chan X, Brown B, Hurder A, Narisawa S, Millán JL.

J Biomol Screen. 2009 Aug;14(7):824-37. doi: 10.1177/1087057109338517. Epub 2009 Jun 25.

7.

Synthesis and evaluation of thiophenyl derivatives as inhibitors of alkaline phosphatase.

Chang L, Duy do L, Mébarek S, Popowycz F, Pellet-Rostaing S, Lemaire M, Buchet R.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2297-301. doi: 10.1016/j.bmcl.2011.02.089. Epub 2011 Mar 21.

PMID:
21421310
8.

Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatases.

Li L, Chang L, Pellet-Rostaing S, Liger F, Lemaire M, Buchet R, Wu Y.

Bioorg Med Chem. 2009 Oct 15;17(20):7290-300. doi: 10.1016/j.bmc.2009.08.048. Epub 2009 Sep 3.

PMID:
19781951
9.

Synthesis, alkaline phosphatase inhibition studies and molecular docking of novel derivatives of 4-quinolones.

Miliutina M, Ejaz SA, Khan SU, Iaroshenko VO, Villinger A, Iqbal J, Langer P.

Eur J Med Chem. 2017 Jan 27;126:408-420. doi: 10.1016/j.ejmech.2016.11.036. Epub 2016 Nov 17.

PMID:
27907877
10.

Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: Structure activity relationship and molecular modelling studies.

Al-Rashida M, Ejaz SA, Ali S, Shaukat A, Hamayoun M, Ahmed M, Iqbal J.

Bioorg Med Chem. 2015 May 15;23(10):2435-44. doi: 10.1016/j.bmc.2015.03.054. Epub 2015 Mar 27.

PMID:
25865133
11.

Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors.

Orvieto F, Branca D, Giomini C, Jones P, Koch U, Ontoria JM, Palumbi MC, Rowley M, Toniatti C, Muraglia E.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4196-200. doi: 10.1016/j.bmcl.2009.05.113. Epub 2009 Jun 2.

PMID:
19541484
12.

Efficient one-pot synthesis of 5-perfluoroalkylpyrazoles by cyclization of hydrazone dianions.

Ngo TN, Ejaz SA, Hung TQ, Dang TT, Iqbal J, Lecka J, Sévigny J, Langer P.

Org Biomol Chem. 2015 Aug 14;13(30):8277-90. doi: 10.1039/c5ob01151e.

PMID:
26140545
13.

Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.

Chen HJ, Liu Y, Wang LN, Shen Q, Li J, Nan FJ.

Bioorg Med Chem Lett. 2010 May 1;20(9):2876-9. doi: 10.1016/j.bmcl.2010.03.040. Epub 2010 Mar 11.

PMID:
20363629
14.

Synthesis of benzofuran derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase: effects on cell toxicity and osteoblast-induced mineralization.

Marquès S, Buchet R, Popowycz F, Lemaire M, Mebarek S.

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1457-9. doi: 10.1016/j.bmcl.2016.01.061. Epub 2016 Jan 22.

PMID:
26860736
15.

The use of tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 inhibitors to affect mineralization by cultured cells.

Kiffer-Moreira T, Narisawa S.

Methods Mol Biol. 2013;1053:125-34. doi: 10.1007/978-1-62703-562-0_8.

PMID:
23860651
16.

Modulators of intestinal alkaline phosphatase.

Bobkova EV, Kiffer-Moreira T, Sergienko EA.

Methods Mol Biol. 2013;1053:135-44. doi: 10.1007/978-1-62703-562-0_9.

PMID:
23860652
17.

A method for direct assessment of tissue-nonspecific alkaline phosphatase (TNAP) inhibitors in blood samples.

Sergienko EA, Sun Q, Ma CT.

Methods Mol Biol. 2013;1053:103-13. doi: 10.1007/978-1-62703-562-0_6.

PMID:
23860649
18.

Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.

Fioravanti R, Desideri N, Biava M, Proietti Monaco L, Grammatica L, Yáñez M.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5128-30. doi: 10.1016/j.bmcl.2013.07.035. Epub 2013 Jul 23.

PMID:
23927971
19.

Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase.

Channar PA, Shah SJ, Hassan S, Nisa ZU, Lecka J, Sévigny J, Bajorath J, Saeed A, Iqbal J.

Chem Biol Drug Des. 2017 Mar;89(3):365-370. doi: 10.1111/cbdd.12861. Epub 2016 Oct 26.

PMID:
27589035
20.

Pyrazole derivatives as new potent and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors.

Nakamura T, Kakinuma H, Amada H, Miyata N, Taniguchi K, Koda A, Sato M.

Bioorg Med Chem. 2004 Dec 1;12(23):6209-19.

PMID:
15519164

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