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Items: 1 to 20 of 104

1.

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis.

Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK.

Neuron. 2008 Nov 26;60(4):582-9. doi: 10.1016/j.neuron.2008.09.033.

2.

Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis.

Berglund ED, Liu C, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams KW, Xu Y, Elmquist JK.

J Clin Invest. 2013 Dec;123(12):5061-70. doi: 10.1172/JCI70338. Erratum in: J Clin Invest. 2014 Apr 1;124(4):1868. Dosage error in article text.

3.

Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors.

Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly S, Heisler LK.

Endocrinology. 2008 Mar;149(3):1323-8.

4.

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.

Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK.

Nat Neurosci. 2010 Dec;13(12):1457-9. doi: 10.1038/nn.2664.

5.

Serotonin 5-hydroxytryptamine2C receptor signaling in hypothalamic proopiomelanocortin neurons: role in energy homeostasis in females.

Qiu J, Xue C, Bosch MA, Murphy JG, Fan W, Rønnekleiv OK, Kelly MJ.

Mol Pharmacol. 2007 Oct;72(4):885-96.

6.

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons.

Burke LK, Doslikova B, D'Agostino G, Greenwald-Yarnell M, Georgescu T, Chianese R, Martinez de Morentin PB, Ogunnowo-Bada E, Cansell C, Valencia-Torres L, Garfield AS, Apergis-Schoute J, Lam DD, Speakman JR, Rubinstein M, Low MJ, Rochford JJ, Myers MG, Evans ML, Heisler LK.

Mol Metab. 2016 Jan 22;5(3):245-52. doi: 10.1016/j.molmet.2016.01.005.

7.

A serotonin and melanocortin circuit mediates D-fenfluramine anorexia.

Xu Y, Jones JE, Lauzon DA, Anderson JG, Balthasar N, Heisler LK, Zinn AR, Lowell BB, Elmquist JK.

J Neurosci. 2010 Nov 3;30(44):14630-4. doi: 10.1523/JNEUROSCI.5412-09.2010.

8.

5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated.

Doslikova B, Garfield AS, Shaw J, Evans ML, Burdakov D, Billups B, Heisler LK.

J Neurosci. 2013 Jun 5;33(23):9800-4. doi: 10.1523/JNEUROSCI.4326-12.2013.

9.

Central serotonin and melanocortin pathways regulating energy homeostasis.

Heisler LK, Cowley MA, Kishi T, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro J, Zigman JM, Cone RD, Elmquist JK.

Ann N Y Acad Sci. 2003 Jun;994:169-74. Review.

PMID:
12851313
10.

Dynamic 5-HT2C receptor editing in a mouse model of obesity.

Schellekens H, Clarke G, Jeffery IB, Dinan TG, Cryan JF.

PLoS One. 2012;7(3):e32266. doi: 10.1371/journal.pone.0032266.

11.

Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood.

Nasif S, de Souza FS, González LE, Yamashita M, Orquera DP, Low MJ, Rubinstein M.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1861-70. doi: 10.1073/pnas.1500672112.

12.

Serotonin 5-HT2C receptor-mediated inhibition of the M-current in hypothalamic POMC neurons.

Roepke TA, Smith AW, Rønnekleiv OK, Kelly MJ.

Am J Physiol Endocrinol Metab. 2012 Jun 1;302(11):E1399-406. doi: 10.1152/ajpendo.00565.2011.

13.

Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice.

Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carling D, Withers DJ.

Diabetes. 2011 Mar;60(3):735-45. doi: 10.2337/db10-1055.

14.

Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene.

Nonogaki K, Ohba Y, Wakameda M, Tamari T.

Int J Neuropsychopharmacol. 2009 May;12(4):547-52. doi: 10.1017/S1461145708009619.

PMID:
18976545
15.

Hypothalamic orexin and pro-opiomelanocortin activities are essential for the anorexic effects of m-chlorophenylpiperazine in mice.

Nonogaki K, Kaji T.

Int J Neuropsychopharmacol. 2010 Oct;13(9):1261-7. doi: 10.1017/S1461145710000672.

PMID:
20587130
16.

Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.

De Jonghe BC, Hayes MR, Zimmer DJ, Kanoski SE, Grill HJ, Bence KK.

Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E644-51. doi: 10.1152/ajpendo.00009.2012.

17.

Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.

Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK.

Neuron. 2011 Aug 11;71(3):488-97. doi: 10.1016/j.neuron.2011.06.012.

18.

5-HT obesity medication efficacy via POMC activation is maintained during aging.

Burke LK, Doslikova B, D'Agostino G, Garfield AS, Farooq G, Burdakov D, Low MJ, Rubinstein M, Evans ML, Billups B, Heisler LK.

Endocrinology. 2014 Oct;155(10):3732-8. doi: 10.1210/en.2014-1223.

19.

Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice.

Nonogaki K, Kaji T, Ohba Y, Sumii M, Wakameda M, Tamari T.

Biochem Biophys Res Commun. 2009 Aug 21;386(2):311-5. doi: 10.1016/j.bbrc.2009.06.023.

PMID:
19523439
20.

Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity.

Pritchard LE, Turnbull AV, White A.

J Endocrinol. 2002 Mar;172(3):411-21. Review.

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