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Items: 1 to 20 of 149

1.

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.

Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18782-7. doi: 10.1073/pnas.0810199105. Epub 2008 Nov 24.

2.

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.

Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ.

Cancer Res. 2009 Oct 15;69(20):7986-93. doi: 10.1158/0008-5472.CAN-09-2266. Epub 2009 Oct 13. Erratum in: Cancer Res. 2010 Feb 1;70(3):1275. Bachoo, Robert G [corrected to Bachoo, Robert M].

3.

Carbon source metabolism and its regulation in cancer cells.

Yin C, Qie S, Sang N.

Crit Rev Eukaryot Gene Expr. 2012;22(1):17-35. Review.

4.

Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression.

Xu X, Li J, Sun X, Guo Y, Chu D, Wei L, Li X, Yang G, Liu X, Yao L, Zhang J, Shen L.

Oncotarget. 2015 Sep 22;6(28):26161-76. doi: 10.18632/oncotarget.4544.

5.

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.

Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, Zeller KI, De Marzo AM, Van Eyk JE, Mendell JT, Dang CV.

Nature. 2009 Apr 9;458(7239):762-5. doi: 10.1038/nature07823. Epub 2009 Feb 15.

6.

The molecular determinants of de novo nucleotide biosynthesis in cancer cells.

Tong X, Zhao F, Thompson CB.

Curr Opin Genet Dev. 2009 Feb;19(1):32-7. doi: 10.1016/j.gde.2009.01.002. Epub 2009 Feb 5. Review.

7.

Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction.

Fogal V, Babic I, Chao Y, Pastorino S, Mukthavaram R, Jiang P, Cho YJ, Pingle SC, Crawford JR, Piccioni DE, Kesari S.

Oncotarget. 2015 Jan 20;6(2):1157-70.

8.

SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma.

Jeong SM, Lee A, Lee J, Haigis MC.

J Biol Chem. 2014 Feb 14;289(7):4135-44. doi: 10.1074/jbc.M113.525949. Epub 2013 Dec 24.

9.

MYC-induced cancer cell energy metabolism and therapeutic opportunities.

Dang CV, Le A, Gao P.

Clin Cancer Res. 2009 Nov 1;15(21):6479-83. doi: 10.1158/1078-0432.CCR-09-0889. Epub 2009 Oct 27. Review.

10.

Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?

Dang CV.

Cell Cycle. 2010 Oct 1;9(19):3884-6. Epub 2010 Oct 9.

PMID:
20948290
11.

Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition.

Fan Y, Dickman KG, Zong WX.

J Biol Chem. 2010 Mar 5;285(10):7324-33. doi: 10.1074/jbc.M109.035584. Epub 2009 Dec 17.

12.

Therapeutic targeting of Myc-reprogrammed cancer cell metabolism.

Dang CV.

Cold Spring Harb Symp Quant Biol. 2011;76:369-74. doi: 10.1101/sqb.2011.76.011296. Epub 2011 Sep 29. Review.

PMID:
21960526
13.

Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells.

Smolková K, Plecitá-Hlavatá L, Bellance N, Benard G, Rossignol R, Ježek P.

Int J Biochem Cell Biol. 2011 Jul;43(7):950-68. doi: 10.1016/j.biocel.2010.05.003. Epub 2010 May 10. Review.

PMID:
20460169
14.

c-Myc programs fatty acid metabolism and dictates acetyl-CoA abundance and fate.

Edmunds LR, Sharma L, Kang A, Lu J, Vockley J, Basu S, Uppala R, Goetzman ES, Beck ME, Scott D, Prochownik EV.

J Biol Chem. 2014 Sep 5;289(36):25382-92. doi: 10.1074/jbc.M114.580662. Epub 2014 Jul 22. Erratum in: J Biol Chem. 2015 Aug 14;290(33):20100.

15.

Rethinking the Warburg effect with Myc micromanaging glutamine metabolism.

Dang CV.

Cancer Res. 2010 Feb 1;70(3):859-62. doi: 10.1158/0008-5472.CAN-09-3556. Epub 2010 Jan 19. Review.

16.

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.

Gaglio D, Metallo CM, Gameiro PA, Hiller K, Danna LS, Balestrieri C, Alberghina L, Stephanopoulos G, Chiaradonna F.

Mol Syst Biol. 2011 Aug 16;7:523. doi: 10.1038/msb.2011.56.

17.

MYC, microRNAs and glutamine addiction in cancers.

Dang CV.

Cell Cycle. 2009 Oct 15;8(20):3243-5. Epub 2009 Oct 15.

PMID:
19806017
18.

ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.

Qing G, Li B, Vu A, Skuli N, Walton ZE, Liu X, Mayes PA, Wise DR, Thompson CB, Maris JM, Hogarty MD, Simon MC.

Cancer Cell. 2012 Nov 13;22(5):631-44. doi: 10.1016/j.ccr.2012.09.021.

19.

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.

Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, McCormick LL, Fitzgerald P, Chi H, Munger J, Green DR.

Immunity. 2011 Dec 23;35(6):871-82. doi: 10.1016/j.immuni.2011.09.021.

20.

Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2.

Xiao D, Ren P, Su H, Yue M, Xiu R, Hu Y, Liu H, Qing G.

Oncotarget. 2015 Dec 1;6(38):40655-66. doi: 10.18632/oncotarget.5821.

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