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The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH.

Genes Dev. 2005 Dec 15;19(24):3043-54.


Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y.

J Biol Chem. 2006 Oct 13;281(41):30814-23. Epub 2006 Aug 10.


Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

Williams RS, Williams JS, Tainer JA.

Biochem Cell Biol. 2007 Aug;85(4):509-20. Review.


Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.

Lee JH, Xu B, Lee CH, Ahn JY, Song MS, Lee H, Canman CE, Lee JS, Kastan MB, Lim DS.

Mol Cancer Res. 2003 Jul;1(9):674-81.


The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.

Yu Z, Vogel G, Coulombe Y, Dubeau D, Spehalski E, H├ębert J, Ferguson DO, Masson JY, Richard S.

Cell Res. 2012 Feb;22(2):305-20. doi: 10.1038/cr.2011.128. Epub 2011 Aug 9.


p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

Song H, Hollstein M, Xu Y.

Nat Cell Biol. 2007 May;9(5):573-80. Epub 2007 Apr 8.


Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.

Shull ER, Lee Y, Nakane H, Stracker TH, Zhao J, Russell HR, Petrini JH, McKinnon PJ.

Genes Dev. 2009 Jan 15;23(2):171-80. doi: 10.1101/gad.1746609.


Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.

Stracker TH, Couto SS, Cordon-Cardo C, Matos T, Petrini JH.

Mol Cell. 2008 Jul 11;31(1):21-32. doi: 10.1016/j.molcel.2008.04.028. Erratum in: Mol Cell. 2008 Dec 26;32(6):889.


TIS21(/BTG2/PC3) accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2(T68)-p53(S20) pathway.

Choi KS, Kim JY, Lim SK, Choi YW, Kim YH, Kang SY, Park TJ, Lim IK.

DNA Repair (Amst). 2012 Dec 1;11(12):965-75. doi: 10.1016/j.dnarep.2012.09.009. Epub 2012 Oct 22.


Ataxia-telangiectasia and related diseases.

Frappart PO, McKinnon PJ.

Neuromolecular Med. 2006;8(4):495-511. Review.


E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.

Powers JT, Hong S, Mayhew CN, Rogers PM, Knudsen ES, Johnson DG.

Mol Cancer Res. 2004 Apr;2(4):203-14.


ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.

Rahal EA, Henricksen LA, Li Y, Williams RS, Tainer JA, Dixon K.

Cell Cycle. 2010 Jul 15;9(14):2866-77. Epub 2010 Jul 12.


The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks.

Lavin MF.

DNA Repair (Amst). 2004 Nov 2;3(11):1515-20. Review. Erratum in: DNA Repair (Amst). 2005 Apr 4;4(4):519.


PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin.

Di Virgilio M, Ying CY, Gautier J.

DNA Repair (Amst). 2009 Nov 2;8(11):1311-20. doi: 10.1016/j.dnarep.2009.07.006. Epub 2009 Aug 25.


Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.

Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, Xu Y.

Mol Cell Biol. 2005 Jan;25(2):661-70.


Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation.

Zhao H, Traganos F, Albino AP, Darzynkiewicz Z.

Cell Cycle. 2008 May 15;7(10):1490-5. Epub 2008 Mar 18.


Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation.

Mendez G, Cilli D, Berardinelli F, Viganotti M, Ascenzi P, Tanzarella C, Antoccia A, di Masi A.

IUBMB Life. 2012 Oct;64(10):853-61. doi: 10.1002/iub.1077. Epub 2012 Sep 3.


Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.

Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW.

Mol Cell Biol. 2002 Sep;22(18):6521-32.

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