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Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.

Masada N, Ciruela A, Macdougall DA, Cooper DM.

J Biol Chem. 2009 Feb 13;284(7):4451-63. doi: 10.1074/jbc.M807359200. Epub 2008 Nov 24. Erratum in: J Biol Chem. 2010 Jun 4;285(23):18122.


Distinct mechanisms of calmodulin binding and regulation of adenylyl cyclases 1 and 8.

Masada N, Schaks S, Jackson SE, Sinz A, Cooper DM.

Biochemistry. 2012 Oct 9;51(40):7917-29. doi: 10.1021/bi300646y. Epub 2012 Sep 21.


Structural insights into calmodulin/adenylyl cyclase 8 interaction.

Herbst S, Masada N, Pfennig S, Ihling CH, Cooper DM, Sinz A.

Anal Bioanal Chem. 2013 Nov;405(29):9333-42. doi: 10.1007/s00216-013-7358-3. Epub 2013 Sep 27.


The type 8 adenylyl cyclase is critical for Ca2+ stimulation of cAMP accumulation in mouse parotid acini.

Watson EL, Jacobson KL, Singh JC, Idzerda R, Ott SM, DiJulio DH, Wong ST, Storm DR.

J Biol Chem. 2000 May 12;275(19):14691-9.


Identification of FDA-Approved Small Molecules Capable of Disrupting the Calmodulin-Adenylyl Cyclase 8 Interaction through Direct Binding to Calmodulin.

Hayes MP, Soto-Velasquez M, Fowler CA, Watts VJ, Roman DL.

ACS Chem Neurosci. 2018 Feb 21;9(2):346-357. doi: 10.1021/acschemneuro.7b00349. Epub 2017 Oct 16.


Residence of adenylyl cyclase type 8 in caveolae is necessary but not sufficient for regulation by capacitative Ca(2+) entry.

Smith KE, Gu C, Fagan KA, Hu B, Cooper DM.

J Biol Chem. 2002 Feb 22;277(8):6025-31. Epub 2001 Dec 13.


Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain.

Conti AC, Maas JW Jr, Muglia LM, Dave BA, Vogt SK, Tran TT, Rayhel EJ, Muglia LJ.

Neuroscience. 2007 May 11;146(2):713-29. Epub 2007 Feb 28.


Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory.

Zhang M, Moon C, Chan GC, Yang L, Zheng F, Conti AC, Muglia L, Muglia LJ, Storm DR, Wang H.

J Neurosci. 2008 Apr 30;28(18):4736-44. doi: 10.1523/JNEUROSCI.1177-08.2008.


Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain.

Kaur J, Soto-Velasquez M, Ding Z, Ghanbarpour A, Lill MA, van Rijn RM, Watts VJ, Flaherty DP.

Eur J Med Chem. 2019 Jan 15;162:568-585. doi: 10.1016/j.ejmech.2018.11.036. Epub 2018 Nov 16.


Absence of Ca2+-stimulated adenylyl cyclases leads to reduced synaptic plasticity and impaired experience-dependent fear memory.

Wieczorek L, Majumdar D, Wills TA, Hu L, Winder DG, Webb DJ, Muglia LJ.

Transl Psychiatry. 2012 May 29;2:e126. doi: 10.1038/tp.2012.50.


A role for calmodulin-stimulated adenylyl cyclases in cocaine sensitization.

DiRocco DP, Scheiner ZS, Sindreu CB, Chan GC, Storm DR.

J Neurosci. 2009 Feb 25;29(8):2393-403. doi: 10.1523/JNEUROSCI.4356-08.2009.


Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibition.

Macdougall DA, Wachten S, Ciruela A, Sinz A, Cooper DM.

J Biol Chem. 2009 Jun 5;284(23):15573-88. doi: 10.1074/jbc.M809585200. Epub 2009 Mar 21.


Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses.

Li S, Lee ML, Bruchas MR, Chan GC, Storm DR, Chavkin C.

Mol Pharmacol. 2006 Nov;70(5):1742-9. Epub 2006 Aug 16.


AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems.

Willoughby D, Masada N, Wachten S, Pagano M, Halls ML, Everett KL, Ciruela A, Cooper DM.

J Biol Chem. 2010 Jun 25;285(26):20328-42. doi: 10.1074/jbc.M110.120725. Epub 2010 Apr 21.


Direct demonstration of discrete Ca2+ microdomains associated with different isoforms of adenylyl cyclase.

Willoughby D, Wachten S, Masada N, Cooper DM.

J Cell Sci. 2010 Jan 1;123(Pt 1):107-17. doi: 10.1242/jcs.062067.


Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor.

L├╝bker C, Seifert R.

PLoS One. 2015 May 6;10(5):e0124017. doi: 10.1371/journal.pone.0124017. eCollection 2015.


The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8.

Simpson RE, Ciruela A, Cooper DM.

J Biol Chem. 2006 Jun 23;281(25):17379-89. Epub 2006 Apr 13.


Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry.

Pagano M, Clynes MA, Masada N, Ciruela A, Ayling LJ, Wachten S, Cooper DM.

Am J Physiol Cell Physiol. 2009 Mar;296(3):C607-19. doi: 10.1152/ajpcell.00488.2008. Epub 2009 Jan 21.


Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor.

Baker LP, Nielsen MD, Impey S, Metcalf MA, Poser SW, Chan G, Obrietan K, Hamblin MW, Storm DR.

J Biol Chem. 1998 Jul 10;273(28):17469-76.


Calmodulin-regulated adenylyl cyclases: cross-talk and plasticity in the central nervous system.

Wang H, Storm DR.

Mol Pharmacol. 2003 Mar;63(3):463-8. Review.


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