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The RNA-activated protein kinase enhances the induction of interferon-beta and apoptosis mediated by cytoplasmic RNA sensors.

McAllister CS, Samuel CE.

J Biol Chem. 2009 Jan 16;284(3):1644-51. doi: 10.1074/jbc.M807888200. Epub 2008 Nov 20.


Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein.

Zhang L, Xiang W, Wang G, Yan Z, Zhu Z, Guo Z, Sengupta R, Chen AF, Loughran PA, Lu B, Wang Q, Billiar TR.

J Biol Chem. 2016 Jul 15;291(29):15093-107. doi: 10.1074/jbc.M116.717942. Epub 2016 May 17.


Long double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-beta promoter stimulator 1, and IFN.

DeWitte-Orr SJ, Mehta DR, Collins SE, Suthar MS, Gale M Jr, Mossman KL.

J Immunol. 2009 Nov 15;183(10):6545-53. doi: 10.4049/jimmunol.0900867. Epub 2009 Oct 28.


Protein kinase regulated by dsRNA downregulates the interferon production in dengue virus- and dsRNA-stimulated human lung epithelial cells.

Li Y, Xie J, Wu S, Xia J, Zhang P, Liu C, Zhang P, Huang X.

PLoS One. 2013;8(1):e55108. doi: 10.1371/journal.pone.0055108. Epub 2013 Jan 25.


Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia.

Harada K, Sato Y, Itatsu K, Isse K, Ikeda H, Yasoshima M, Zen Y, Matsui A, Nakanuma Y.

Hepatology. 2007 Oct;46(4):1146-54.


Signal regulatory protein alpha negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction.

Dong LW, Kong XN, Yan HX, Yu LX, Chen L, Yang W, Liu Q, Huang DD, Wu MC, Wang HY.

Mol Immunol. 2008 Jun;45(11):3025-35. doi: 10.1016/j.molimm.2008.03.012. Epub 2008 May 8.


The C proteins of human parainfluenza virus type 1 limit double-stranded RNA accumulation that would otherwise trigger activation of MDA5 and protein kinase R.

Boonyaratanakornkit J, Bartlett E, Schomacker H, Surman S, Akira S, Bae YS, Collins P, Murphy B, Schmidt A.

J Virol. 2011 Feb;85(4):1495-506. doi: 10.1128/JVI.01297-10. Epub 2010 Dec 1.


Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells.

Bernardo AR, Cosgaya JM, Aranda A, Jiménez-Lara AM.

Cell Death Dis. 2013 Jan 31;4:e479. doi: 10.1038/cddis.2013.5.


Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-beta production by interfering with the RIG-I signaling pathway.

Luo R, Xiao S, Jiang Y, Jin H, Wang D, Liu M, Chen H, Fang L.

Mol Immunol. 2008 May;45(10):2839-46. doi: 10.1016/j.molimm.2008.01.028. Epub 2008 Mar 11.


TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.

Siednienko J, Halle A, Nagpal K, Golenbock DT, Miggin SM.

Eur J Immunol. 2010 Nov;40(11):3150-60. doi: 10.1002/eji.201040547. Epub 2010 Oct 19.


Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1.

Yeon SH, Song MJ, Kang HR, Lee JY.

Immunology. 2015 Feb;144(2):312-20. doi: 10.1111/imm.12373.


The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3.

Sen A, Pruijssers AJ, Dermody TS, García-Sastre A, Greenberg HB.

J Virol. 2011 Apr;85(8):3717-32. doi: 10.1128/JVI.02634-10. Epub 2011 Feb 9.


B-cell-activating factor expressions in salivary epithelial cells after dsRNA virus infection depends on RNA-activated protein kinase activation.

Ittah M, Miceli-Richard C, Gottenberg JE, Sellam J, Lepajolec C, Mariette X.

Eur J Immunol. 2009 May;39(5):1271-9. doi: 10.1002/eji.200839086.


Protein kinase PKR amplification of interferon β induction occurs through initiation factor eIF-2α-mediated translational control.

McAllister CS, Taghavi N, Samuel CE.

J Biol Chem. 2012 Oct 19;287(43):36384-92. doi: 10.1074/jbc.M112.390039. Epub 2012 Sep 4.


NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.

Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, Seya T.

J Immunol. 2006 Dec 15;177(12):8676-83.


TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.

Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T.

Nat Immunol. 2003 Feb;4(2):161-7. Epub 2003 Jan 21.


Control of FoxO4 Activity and Cell Survival by TRIM22 Directs TLR3-Stimulated Cells Toward IFN Type I Gene Induction or Apoptosis.

Oteiza A, Mechti N.

J Interferon Cytokine Res. 2015 Nov;35(11):859-74. doi: 10.1089/jir.2015.0020. Epub 2015 Aug 3.


Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.

Jiang Z, Mak TW, Sen G, Li X.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3533-8. Epub 2004 Feb 24.


Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.

Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M.

J Immunol. 2007 Nov 15;179(10):6867-72.


A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.

Chessler AD, Ferreira LR, Chang TH, Fitzgerald KA, Burleigh BA.

J Immunol. 2008 Dec 1;181(11):7917-24.

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