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Items: 1 to 20 of 127

1.

Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition.

Hill TA, Stewart SG, Gordon CP, Ackland SP, Gilbert J, Sauer B, Sakoff JA, McCluskey A.

ChemMedChem. 2008 Dec;3(12):1878-92. doi: 10.1002/cmdc.200800192.

PMID:
19025735
2.

Heterocyclic substituted cantharidin and norcantharidin analogues--synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity.

Hill TA, Stewart SG, Sauer B, Gilbert J, Ackland SP, Sakoff JA, McCluskey A.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3392-7. Epub 2007 Apr 2.

PMID:
17451951
3.

Synthesis and biological evaluation of norcantharidin analogues: towards PP1 selectivity.

Stewart SG, Hill TA, Gilbert J, Ackland SP, Sakoff JA, McCluskey A.

Bioorg Med Chem. 2007 Dec 1;15(23):7301-10. Epub 2007 Aug 24.

PMID:
17870547
4.

Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.

McCluskey A, Walkom C, Bowyer MC, Ackland SP, Gardiner E, Sakoff JA.

Bioorg Med Chem Lett. 2001 Nov 19;11(22):2941-6.

PMID:
11677131
5.

Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines.

McCluskey A, Ackland SP, Bowyer MC, Baldwin ML, Garner J, Walkom CC, Sakoff JA.

Bioorg Chem. 2003 Feb;31(1):68-79.

PMID:
12697169
6.

Anhydride modified cantharidin analogues: synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity.

McCluskey A, Bowyer MC, Collins E, Sim ATR, Sakoff JA, Baldwin ML.

Bioorg Med Chem Lett. 2000 Aug 7;10(15):1687-90.

PMID:
10937725
7.

Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.

Hart ME, Chamberlin AR, Walkom C, Sakoff JA, McCluskey A.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1969-73.

PMID:
15050639
8.

Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues.

Sakoff JA, Ackland SP, Baldwin ML, Keane MA, McCluskey A.

Invest New Drugs. 2002 Feb;20(1):1-11.

PMID:
12003183
9.

The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design?

McCluskey A, Ackland SP, Gardiner E, Walkom CC, Sakoff JA.

Anticancer Drug Des. 2001 Dec;16(6):291-303.

PMID:
12375882
10.

Synthesis and biological evaluation of norcantharidin derivatives as protein phosphatase-1 inhibitors.

Zhao J, Guan XW, Chen SW, Hui L.

Bioorg Med Chem Lett. 2015 Jan 15;25(2):363-6. doi: 10.1016/j.bmcl.2014.11.032. Epub 2014 Nov 18.

PMID:
25466711
11.

Exploiting protein phosphatase inhibitors based on cantharidin analogues for cancer drug discovery.

Deng L, Dong J, Wang W.

Mini Rev Med Chem. 2013 Jun 1;13(8):1166-76. Review.

PMID:
23373656
12.

Synthesis and biological activity of Delta-5,6-norcantharimides: importance of the 5,6-bridge.

Thaqi A, Scott JL, Gilbert J, Sakoff JA, McCluskey A.

Eur J Med Chem. 2010 May;45(5):1717-23. doi: 10.1016/j.ejmech.2010.01.004. Epub 2010 Jan 14.

PMID:
20153915
13.

Conjugates of podophyllotoxin and norcantharidin as dual inhibitors of topoisomeraseâ…ˇ and protein phosphatase 2A.

Tang ZB, Chen YZ, Zhao J, Guan XW, Bo YX, Chen SW, Hui L.

Eur J Med Chem. 2016 Nov 10;123:568-576. doi: 10.1016/j.ejmech.2016.07.031. Epub 2016 Jul 18.

PMID:
27517805
14.

Synthesis and antiproliferative assay of norcantharidin derivatives in cancer cells.

Tu GG, Zhan JF, Lv QL, Wang JQ, Kuang BH, Li SH.

Med Chem. 2014 Jun;10(4):376-81.

PMID:
23909288
15.

Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin.

Bertini I, Calderone V, Fragai M, Luchinat C, Talluri E.

J Med Chem. 2009 Aug 13;52(15):4838-43. doi: 10.1021/jm900610k.

PMID:
19601647
16.

Therapeutic effects of cantharidin analogues without bridging ether oxygen on human hepatocellular carcinoma cells.

Yeh CB, Su CJ, Hwang JM, Chou MC.

Eur J Med Chem. 2010 Sep;45(9):3981-5. doi: 10.1016/j.ejmech.2010.05.053. Epub 2010 Jun 1.

PMID:
20691337
17.

The first two cantharidin analogues displaying PP1 selectivity.

McCluskey A, Keane MA, Walkom CC, Bowyer MC, Sim AT, Young DJ, Sakoff JA.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):391-3.

PMID:
11814804
18.

Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation.

Hill TA, Stewart SG, Ackland SP, Gilbert J, Sauer B, Sakoff JA, McCluskey A.

Bioorg Med Chem. 2007 Sep 15;15(18):6126-34. Epub 2007 Jun 20.

PMID:
17606377
19.

The effects of cantharidin analogues on xanthine oxidase.

Tsauer W, Lin JG, Lin PY, Hsu FL, Chiang HC.

Anticancer Res. 1997 May-Jun;17(3C):2095-8.

PMID:
9216670

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