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The ribosomal stalk is required for ribosome binding, depurination of the rRNA and cytotoxicity of ricin A chain in Saccharomyces cerevisiae.

Chiou JC, Li XP, Remacha M, Ballesta JP, Tumer NE.

Mol Microbiol. 2008 Dec;70(6):1441-52. doi: 10.1111/j.1365-2958.2008.06492.x. Epub 2008 Oct 30.


The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells.

May KL, Li XP, Martínez-Azorín F, Ballesta JP, Grela P, Tchórzewski M, Tumer NE.

FEBS J. 2012 Oct;279(20):3925-36. doi: 10.1111/j.1742-4658.2012.08752.x. Epub 2012 Sep 11.


Shiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2.

Chiou JC, Li XP, Remacha M, Ballesta JP, Tumer NE.

Int J Biochem Cell Biol. 2011 Dec;43(12):1792-801. doi: 10.1016/j.biocel.2011.08.018. Epub 2011 Sep 3.


Ribosome depurination is not sufficient for ricin-mediated cell death in Saccharomyces cerevisiae.

Li XP, Baricevic M, Saidasan H, Tumer NE.

Infect Immun. 2007 Jan;75(1):417-28. Epub 2006 Nov 13.


Functional divergence between the two P1-P2 stalk dimers on the ribosome in their interaction with ricin A chain.

Grela P, Li XP, Tchórzewski M, Tumer NE.

Biochem J. 2014 May 15;460(1):59-67. doi: 10.1042/BJ20140014.


Pentameric organization of the ribosomal stalk accelerates recruitment of ricin a chain to the ribosome for depurination.

Li XP, Grela P, Krokowski D, Tchórzewski M, Tumer NE.

J Biol Chem. 2010 Dec 31;285(53):41463-71. doi: 10.1074/jbc.M110.171793. Epub 2010 Oct 25.


Generation of pokeweed antiviral protein mutations in Saccharomyces cerevisiae: evidence that ribosome depurination is not sufficient for cytotoxicity.

Hudak KA, Parikh BA, Di R, Baricevic M, Santana M, Seskar M, Tumer NE.

Nucleic Acids Res. 2004 Aug 10;32(14):4244-56. Print 2004.


Identification of amino acids critical for the cytotoxicity of Shiga toxin 1 and 2 in Saccharomyces cerevisiae.

Di R, Kyu E, Shete V, Saidasan H, Kahn PC, Tumer NE.

Toxicon. 2011 Mar 15;57(4):525-39. doi: 10.1016/j.toxicon.2010.12.006. Epub 2010 Dec 22.


Active center cleft residues of pokeweed antiviral protein mediate its high-affinity binding to the ribosomal protein L3.

Rajamohan F, Ozer Z, Mao C, Uckun FM.

Biochemistry. 2001 Aug 7;40(31):9104-14.


Maize ribosome-inactivating protein uses Lys158-lys161 to interact with ribosomal protein P2 and the strength of interaction is correlated to the biological activities.

Wong YT, Ng YM, Mak AN, Sze KH, Wong KB, Shaw PC.

PLoS One. 2012;7(12):e49608. doi: 10.1371/journal.pone.0049608. Epub 2012 Dec 12.


Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk.

Li XP, Kahn PC, Kahn JN, Grela P, Tumer NE.

J Biol Chem. 2013 Oct 18;288(42):30270-84. doi: 10.1074/jbc.M113.510966. Epub 2013 Sep 3.


A two-step binding model proposed for the electrostatic interactions of ricin a chain with ribosomes.

Li XP, Chiou JC, Remacha M, Ballesta JP, Tumer NE.

Biochemistry. 2009 May 12;48(18):3853-63. doi: 10.1021/bi802371h.


Pokeweed antiviral protein accesses ribosomes by binding to L3.

Hudak KA, Dinman JD, Tumer NE.

J Biol Chem. 1999 Feb 5;274(6):3859-64.


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