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Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60.

Ryu SJ, Jung KM, Yoo HS, Kim TW, Kim S, Chang J, Choi EY.

Blood. 2009 Apr 30;113(18):4273-80. doi: 10.1182/blood-2008-09-181263. Epub 2009 Jan 12.


Cutting edge: CD4+ T cell help can be essential for primary CD8+ T cell responses in vivo.

Wang JC, Livingstone AM.

J Immunol. 2003 Dec 15;171(12):6339-43.


IL-2 is required for the activation of memory CD8+ T cells via antigen cross-presentation.

Blachère NE, Morris HK, Braun D, Saklani H, Di Santo JP, Darnell RB, Albert ML.

J Immunol. 2006 Jun 15;176(12):7288-300.


CD4+ Th-APC with acquired peptide/MHC class I and II complexes stimulate type 1 helper CD4+ and central memory CD8+ T cell responses.

Umeshappa CS, Huang H, Xie Y, Wei Y, Mulligan SJ, Deng Y, Xiang J.

J Immunol. 2009 Jan 1;182(1):193-206.


A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory.

Bourgeois C, Rocha B, Tanchot C.

Science. 2002 Sep 20;297(5589):2060-3.


Cutting edge: a critical role for CD70 in CD8 T cell priming by CD40-licensed APCs.

Taraban VY, Rowley TF, Al-Shamkhani A.

J Immunol. 2004 Dec 1;173(11):6542-6.


The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells.

Valenzuela J, Schmidt C, Mescher M.

J Immunol. 2002 Dec 15;169(12):6842-9.


CD27 instructs CD4+ T cells to provide help for the memory CD8+ T cell response after protein immunization.

Xiao Y, Peperzak V, Keller AM, Borst J.

J Immunol. 2008 Jul 15;181(2):1071-82.


IL-15-dependent induction of 4-1BB promotes antigen-independent CD8 memory T cell survival.

Pulle G, Vidric M, Watts TH.

J Immunol. 2006 Mar 1;176(5):2739-48.


Direct CD4 help provision following interaction of memory CD4 and CD8 T cells with distinct antigen-presenting dendritic cells.

de Goër de Herve MG, Dembele B, Vallée M, Herr F, Cariou A, Taoufik Y.

J Immunol. 2010 Jul 15;185(2):1028-36. doi: 10.4049/jimmunol.0904209. Epub 2010 Jun 18.


Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections.

Bachmann MF, Wolint P, Walton S, Schwarz K, Oxenius A.

Eur J Immunol. 2007 Jun;37(6):1502-12.


IL-4 deficiency does not impair the ability of dendritic cells to initiate CD4+ and CD8+ T cell responses in vivo.

Roberts JM, Yang J, Ronchese F.

Int Immunol. 2004 Oct;16(10):1451-8. Epub 2004 Aug 23.


IL-12-programmed long-term CD8+ T cell responses require STAT4.

Li Q, Eppolito C, Odunsi K, Shrikant PA.

J Immunol. 2006 Dec 1;177(11):7618-25.


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