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Items: 1 to 20 of 145

1.

Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans.

Ropero AB, Juan-Picó P, Rafacho A, Fuentes E, Bermúdez-Silva FJ, Roche E, Quesada I, de Fonseca FR, Nadal A.

J Endocrinol. 2009 Feb;200(2):127-38. doi: 10.1677/JOE-08-0397. Epub 2008 Nov 18.

2.

Dopamine D2-like receptors are expressed in pancreatic beta cells and mediate inhibition of insulin secretion.

Rubí B, Ljubicic S, Pournourmohammadi S, Carobbio S, Armanet M, Bartley C, Maechler P.

J Biol Chem. 2005 Nov 4;280(44):36824-32. Epub 2005 Aug 29.

3.

BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity, raises cytosolic Ca2+, and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner.

Zhang F, Dey D, Bränström R, Forsberg L, Lu M, Zhang Q, Sjöholm A.

Am J Physiol Cell Physiol. 2009 Feb;296(2):C346-54. doi: 10.1152/ajpcell.00444.2008. Epub 2008 Dec 3.

4.

Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha).

Guzmán M, Lo Verme J, Fu J, Oveisi F, Blázquez C, Piomelli D.

J Biol Chem. 2004 Jul 2;279(27):27849-54. Epub 2004 Apr 26.

5.

Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells.

Muoio DM, Way JM, Tanner CJ, Winegar DA, Kliewer SA, Houmard JA, Kraus WE, Dohm GL.

Diabetes. 2002 Apr;51(4):901-9.

6.

Peroxisome proliferator-activated receptor-alpha modulates insulin gene transcription factors and inflammation in adipose tissues in mice.

Yessoufou A, Atègbo JM, Attakpa E, Hichami A, Moutairou K, Dramane KL, Khan NA.

Mol Cell Biochem. 2009 Mar;323(1-2):101-11. doi: 10.1007/s11010-008-9968-1. Epub 2008 Nov 28.

PMID:
19039651
7.

Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40.

Schnell S, Schaefer M, Schöfl C.

Mol Cell Endocrinol. 2007 Jan 15;263(1-2):173-80. Epub 2006 Nov 13.

PMID:
17101212
8.

Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion.

Kawaguchi M, Minami K, Nagashima K, Seino S.

J Biol Chem. 2006 May 12;281(19):13015-20. Epub 2006 Mar 16.

9.

Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia.

D'Agostino G, La Rana G, Russo R, Sasso O, Iacono A, Esposito E, Mattace Raso G, Cuzzocrea S, Loverme J, Piomelli D, Meli R, Calignano A.

Eur J Pharmacol. 2009 Jun 24;613(1-3):54-9. doi: 10.1016/j.ejphar.2009.04.022. Epub 2009 Apr 20.

PMID:
19386271
10.

PPARalpha activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism.

Holness MJ, Greenwood GK, Smith ND, Sugden MC.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1380-9. doi: 10.1152/ajpendo.90700.2008. Epub 2008 Oct 14.

11.

Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets.

Kominato R, Fujimoto S, Mukai E, Nakamura Y, Nabe K, Shimodahira M, Nishi Y, Funakoshi S, Seino Y, Inagaki N.

Diabetologia. 2008 Jul;51(7):1226-35. doi: 10.1007/s00125-008-1008-x. Epub 2008 May 1.

PMID:
18449527
12.

Effects of c-MYC activation on glucose stimulus-secretion coupling events in mouse pancreatic islets.

Pascal SM, Guiot Y, Pelengaris S, Khan M, Jonas JC.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E92-102. doi: 10.1152/ajpendo.90235.2008. Epub 2008 Apr 15.

13.

Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells.

Uchida T, Iwashita N, Ohara-Imaizumi M, Ogihara T, Nagai S, Choi JB, Tamura Y, Tada N, Kawamori R, Nakayama KI, Nagamatsu S, Watada H.

J Biol Chem. 2007 Jan 26;282(4):2707-16. Epub 2006 Nov 29.

14.

Effects of bezafibrate on beta-cell function of rat pancreatic islets.

Yoshikawa H, Tajiri Y, Sako Y, Hashimoto T, Umeda F, Nawata H.

Eur J Pharmacol. 2001 Aug 31;426(3):201-6.

PMID:
11527545
15.

Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells.

Lee JW, Kim WH, Lim JH, Song EH, Song J, Choi KY, Jung MH.

Cell Signal. 2009 Jan;21(1):69-78. doi: 10.1016/j.cellsig.2008.09.015. Epub 2008 Oct 7.

PMID:
18940247
17.
18.

Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells.

Mármol P, Pardo B, Wiederkehr A, del Arco A, Wollheim CB, Satrústegui J.

J Biol Chem. 2009 Jan 2;284(1):515-24. doi: 10.1074/jbc.M806729200. Epub 2008 Nov 7.

19.

Extract isolated from Angelica hirsutiflora with insulin secretagogue activity.

Leu YL, Chen YW, Yang CY, Huang CF, Lin GH, Tsai KS, Yang RS, Liu SH.

J Ethnopharmacol. 2009 Jun 22;123(2):208-12. doi: 10.1016/j.jep.2009.03.027. Epub 2009 Mar 26.

PMID:
19429364
20.

Triggering and amplification of insulin secretion by dimethyl alpha-ketoglutarate, a membrane permeable alpha-ketoglutarate analogue.

Willenborg M, Panten U, Rustenbeck I.

Eur J Pharmacol. 2009 Apr 1;607(1-3):41-6. doi: 10.1016/j.ejphar.2009.02.014. Epub 2009 Feb 20.

PMID:
19233162

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