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Items: 1 to 20 of 100

1.

Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.

Green LS, Bullard JM, Ribble W, Dean F, Ayers DF, Ochsner UA, Janjic N, Jarvis TC.

Antimicrob Agents Chemother. 2009 Jan;53(1):86-94. doi: 10.1128/AAC.00275-08. Epub 2008 Nov 17.

2.

Recent advances in the preclinical evaluation of the topical antibacterial agent REP8839.

Critchley IA, Ochsner UA.

Curr Opin Chem Biol. 2008 Aug;12(4):409-17. doi: 10.1016/j.cbpa.2008.06.011. Epub 2008 Jul 11. Review.

PMID:
18620074
3.

Mode of action and biochemical characterization of REP8839, a novel inhibitor of methionyl-tRNA synthetase.

Ochsner UA, Young CL, Stone KC, Dean FB, Janjic N, Critchley IA.

Antimicrob Agents Chemother. 2005 Oct;49(10):4253-62.

4.

Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections.

Critchley IA, Green LS, Young CL, Bullard JM, Evans RJ, Price M, Jarvis TC, Guiles JW, Janjic N, Ochsner UA.

J Antimicrob Chemother. 2009 May;63(5):954-63. doi: 10.1093/jac/dkp041. Epub 2009 Mar 3.

PMID:
19258353
5.

Antibacterial activity of REP8839, a new antibiotic for topical use.

Critchley IA, Young CL, Stone KC, Ochsner UA, Guiles J, Tarasow T, Janjic N.

Antimicrob Agents Chemother. 2005 Oct;49(10):4247-52.

6.

Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold.

Tandon M, Coffen DL, Gallant P, Keith D, Ashwell MA.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1909-11.

PMID:
15050625
7.

Identification of novel inhibitors of methionyl-tRNA synthetase (MetRS) by virtual screening.

Finn J, Stidham M, Hilgers M, G C K.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3932-7. doi: 10.1016/j.bmcl.2008.06.032. Epub 2008 Jun 13.

PMID:
18590962
8.

Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

Jarvest RL, Berge JM, Berry V, Boyd HF, Brown MJ, Elder JS, Forrest AK, Fosberry AP, Gentry DR, Hibbs MJ, Jaworski DD, O'Hanlon PJ, Pope AJ, Rittenhouse S, Sheppard RJ, Slater-Radosti C, Worby A.

J Med Chem. 2002 May 9;45(10):1959-62.

PMID:
11985462
9.
10.

Pharmacophore identification and virtual screening for methionyl-tRNA synthetase inhibitors.

Bharatham N, Bharatham K, Lee KW.

J Mol Graph Model. 2007 Mar;25(6):813-23. Epub 2006 Aug 14.

PMID:
16996282
11.

3-D-QSAR study and molecular docking of methionyl-tRNA synthetase inhibitors.

Kim SY, Lee J.

Bioorg Med Chem. 2003 Dec 1;11(24):5325-31.

PMID:
14642576
12.

Yeast cytoplasmic and mitochondrial methionyl-tRNA synthetases: two structural frameworks for identical functions.

Senger B, Despons L, Walter P, Jakubowski H, Fasiolo F.

J Mol Biol. 2001 Aug 3;311(1):205-16.

PMID:
11469869
13.

Activation of methionine by Escherichia coli methionyl-tRNA synthetase.

Ghosh G, Pelka H, Schulman LH, Brunie S.

Biochemistry. 1991 Oct 8;30(40):9569-75.

PMID:
1911742
14.
15.

Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors.

Finn J, Mattia K, Morytko M, Ram S, Yang Y, Wu X, Mak E, Gallant P, Keith D.

Bioorg Med Chem Lett. 2003 Jul 7;13(13):2231-4.

PMID:
12798340
17.

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown P, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Pope AJ, Rittenhouse S.

Bioorg Med Chem Lett. 2003 Apr 7;13(7):1265-8.

PMID:
12657260
18.

Arginine-395 is required for efficient in vivo and in vitro aminoacylation of tRNAs by Escherichia coli methionyl-tRNA synthetase.

Ghosh G, Kim HY, Demaret JP, Brunie S, Schulman LH.

Biochemistry. 1991 Dec 24;30(51):11767-74.

PMID:
1751493
19.

Incorporation of the Arc1p tRNA-binding domain to the catalytic core of MetRS can functionally replace the yeast Arc1p-MetRS complex.

Karanasios E, Boleti H, Simos G.

J Mol Biol. 2008 Sep 5;381(3):763-71. doi: 10.1016/j.jmb.2008.06.044. Epub 2008 Jun 21.

PMID:
18598703
20.

Horizontal transfer of drug-resistant aminoacyl-transfer-RNA synthetases of anthrax and Gram-positive pathogens.

Brown JR, Gentry D, Becker JA, Ingraham K, Holmes DJ, Stanhope MJ.

EMBO Rep. 2003 Jul;4(7):692-8.

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