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Items: 1 to 20 of 168

1.

Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists.

Cole AG, Metzger A, Brescia MR, Qin LY, Appell KC, Brain CT, Hallett A, Ganju P, Denholm AA, Wareing JR, Ritchie TJ, Drake GM, Bevan SJ, MacGloinn A, McBryde A, Patel V, Oakley PJ, Nunez X, Gstach H, Schneider P, Baldwin JJ, Dolle RE, McDonald E, Henderson I.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):119-22. doi: 10.1016/j.bmcl.2008.11.005. Epub 2008 Nov 6.

PMID:
19014884
2.

Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides.

Biswas K, Li A, Chen JJ, D'Amico DC, Fotsch C, Han N, Human J, Liu Q, Norman MH, Riahi B, Yuan C, Suzuki H, Mareska DA, Zhan J, Clarke DE, Toro A, Groneberg RD, Burgess LE, Lester-Zeiner D, Biddlecome G, Manning BH, Arik L, Dong H, Huang M, Kamassah A, Loeloff R, Sun H, Hsieh FY, Kumar G, Ng GY, Hungate RW, Askew BC, Johnson E.

J Med Chem. 2007 May 3;50(9):2200-12. Epub 2007 Apr 5.

PMID:
17408249
3.

Small molecule antagonists of the bradykinin B1 receptor.

Horlick RA, Ohlmeyer MH, Stroke IL, Strohl B, Pan G, Schilling AE, Paradkar V, Quintero JG, You M, Riviello C, Thorn MB, Damaj B, Fitzpatrick VD, Dolle RE, Webb ML, Baldwin JJ, Sigal NH.

Immunopharmacology. 1999 Sep;43(2-3):169-77.

PMID:
10596850
4.

Aryl sulfonamides containing tetralin allylic amines as potent and selective bradykinin B1 receptor antagonists.

Liu Q, Qian W, Li A, Biswas K, Chen JJ, Fotsch C, Han N, Yuan C, Arik L, Biddlecome G, Johnson E, Kumar G, Lester-Zeiner D, Ng GY, Hungate RW, Askew BC.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4593-7. doi: 10.1016/j.bmcl.2010.06.010. Epub 2010 Jun 8.

PMID:
20573508
5.

1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.

Guo Q, Chandrasekhar J, Ihle D, Wustrow DJ, Chenard BL, Krause JE, Hutchison A, Alderman D, Cheng C, Cortright D, Broom D, Kershaw MT, Simmermacher-Mayer J, Peng Y, Hodgetts KJ.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5027-31. doi: 10.1016/j.bmcl.2008.08.014. Epub 2008 Aug 9.

PMID:
18752949
6.

From bradykinin B2 receptor antagonists to orally active and selective bradykinin B1 receptor antagonists.

Barth M, Bondoux M, Luccarini JM, Peyrou V, Dodey P, Pruneau D, Massardier C, Paquet JL.

J Med Chem. 2012 Mar 22;55(6):2574-84. doi: 10.1021/jm2016057. Epub 2012 Mar 6.

PMID:
22369198
7.
8.

Novel small molecule bradykinin B1 receptor antagonists. Part 2: 5-membered diaminoheterocycles.

Zischinsky G, Stragies R, Schaudt M, Pfeifer JR, Gibson C, Locardi E, Scharn D, Richter U, Kalkhof H, Dinkel K, Schnatbaum K.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1229-32. doi: 10.1016/j.bmcl.2009.11.120. Epub 2009 Dec 2.

PMID:
20015651
9.

Bradykinin B1 receptor antagonists: an alpha-hydroxy amide with an improved metabolism profile.

Kuduk SD, Chang RK, Dipardo RM, Di Marco CN, Murphy KL, Ransom RW, Reiss DR, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5107-10. doi: 10.1016/j.bmcl.2008.07.126. Epub 2008 Aug 5.

PMID:
18722115
10.

2-Aminobenzophenones as a novel class of bradykinin B1 receptor antagonists.

Su DS, Lim JL, Tinney E, Wan BL, Murphy KL, Reiss DR, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Pettibone DJ, Yu J, Tang C, Prueksaritanont T, Freidinger RM, Bock MG, Anthony NJ.

J Med Chem. 2008 Jul 10;51(13):3946-52. doi: 10.1021/jm800199h. Epub 2008 Jun 14.

PMID:
18553956
11.

Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists.

Chen JJ, Qian W, Biswas K, Viswanadhan VN, Askew BC, Hitchcock S, Hungate RW, Arik L, Johnson E.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4477-81. doi: 10.1016/j.bmcl.2008.07.055. Epub 2008 Jul 17.

PMID:
18674903
12.

Targeting the bradykinin B1 receptor to reduce pain.

Chen JJ, Johnson EJ.

Expert Opin Ther Targets. 2007 Jan;11(1):21-35. Review.

PMID:
17150032
13.

Discovery of potent, orally bioavailable phthalazinone bradykinin B1 receptor antagonists.

Biswas K, Peterkin TA, Bryan MC, Arik L, Lehto SG, Sun H, Hsieh FY, Xu C, Fremeau RT, Allen JR.

J Med Chem. 2011 Oct 27;54(20):7232-46. doi: 10.1021/jm200808v. Epub 2011 Sep 26.

PMID:
21902230
14.

Preparation and optimization of a series of 3-carboxamido-5-phenacylaminopyrazole bradykinin B1 receptor antagonists.

Dressen D, Garofalo AW, Hawkinson J, Hom D, Jagodzinski J, Marugg JL, Neitzel ML, Pleiss MA, Szoke B, Tung JS, Wone DW, Wu J, Zhang H.

J Med Chem. 2007 Oct 18;50(21):5161-7. Epub 2007 Sep 19.

PMID:
17880055
15.

Bradykinin B1 antagonists: SAR studies in the 2,3-diaminopyridine series.

Kuduk SD, Chang RK, Ng C, Murphy KL, Ransom RW, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG.

Bioorg Med Chem Lett. 2005 Sep 1;15(17):3925-9.

PMID:
15993596
16.

Aryl sulfones as novel bradykinin B1 receptor antagonists for treatment of chronic pain.

Biswas K, Aya T, Qian W, Peterkin TA, Chen JJ, Human J, Hungate RW, Kumar G, Arik L, Lester-Zeiner D, Biddlecome G, Manning BH, Sun H, Dong H, Huang M, Loeloff R, Johnson EJ, Askew BC.

Bioorg Med Chem Lett. 2008 Sep 1;18(17):4764-9. doi: 10.1016/j.bmcl.2008.07.108. Epub 2008 Jul 31.

PMID:
18706809
17.

2,3-diaminopyridine bradykinin B1 receptor antagonists.

Kuduk SD, Ng C, Feng DM, Wai JM, Chang RS, Harrell CM, Murphy KL, Ransom RW, Reiss D, Ivarsson M, Mason G, Boyce S, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG.

J Med Chem. 2004 Dec 16;47(26):6439-42.

PMID:
15588075
18.

Non-peptide antagonists for kinin B1 receptors: new insights into their therapeutic potential for the management of inflammation and pain.

Campos MM, Leal PC, Yunes RA, Calixto JB.

Trends Pharmacol Sci. 2006 Dec;27(12):646-51. Epub 2006 Oct 20. Review.

PMID:
17056130
19.

Novel small molecule bradykinin B1 receptor antagonists. Part 1: benzamides and semicarbazides.

Schaudt M, Locardi E, Zischinsky G, Stragies R, Pfeifer JR, Gibson C, Scharn D, Richter U, Kalkhof H, Dinkel K, Schnatbaum K.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1225-8. doi: 10.1016/j.bmcl.2009.11.119. Epub 2009 Dec 2.

PMID:
20015645
20.

Indazole derivatives as novel bradykinin B1 receptor antagonists.

Bodmer-Narkevitch V, Anthony NJ, Cofre V, Jolly SM, Murphy KL, Ransom RW, Reiss DR, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG, Kuduk SD.

Bioorg Med Chem Lett. 2010 Dec 1;20(23):7011-4. doi: 10.1016/j.bmcl.2010.09.121. Epub 2010 Sep 29.

PMID:
20971001

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