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Control of TANK-binding kinase 1-mediated signaling by the gamma(1)34.5 protein of herpes simplex virus 1.

Verpooten D, Ma Y, Hou S, Yan Z, He B.

J Biol Chem. 2009 Jan 9;284(2):1097-105. doi: 10.1074/jbc.M805905200. Epub 2008 Nov 14.


Role of Herpes Simplex Virus 1 γ34.5 in the Regulation of IRF3 Signaling.

Manivanh R, Mehrbach J, Knipe DM, Leib DA.

J Virol. 2017 Nov 14;91(23). pii: e01156-17. doi: 10.1128/JVI.01156-17. Print 2017 Dec 1.


Inhibition of TANK binding kinase 1 by herpes simplex virus 1 facilitates productive infection.

Ma Y, Jin H, Valyi-Nagy T, Cao Y, Yan Z, He B.

J Virol. 2012 Feb;86(4):2188-96. doi: 10.1128/JVI.05376-11. Epub 2011 Dec 14.


Herpes Simplex Virus 1 Serine Protease VP24 Blocks the DNA-Sensing Signal Pathway by Abrogating Activation of Interferon Regulatory Factor 3.

Zhang D, Su C, Zheng C.

J Virol. 2016 May 27;90(12):5824-5829. doi: 10.1128/JVI.00186-16. Print 2016 Jun 15.


Murine gammaherpesvirus 68 encoding open reading frame 11 targets TANK binding kinase 1 to negatively regulate the host type I interferon response.

Kang HR, Cheong WC, Park JE, Ryu S, Cho HJ, Youn H, Ahn JH, Song MJ.

J Virol. 2014 Jun;88(12):6832-46. doi: 10.1128/JVI.03460-13. Epub 2014 Apr 2.


Herpes simplex virus 1 serine/threonine kinase US3 hyperphosphorylates IRF3 and inhibits beta interferon production.

Wang S, Wang K, Lin R, Zheng C.

J Virol. 2013 Dec;87(23):12814-27. doi: 10.1128/JVI.02355-13. Epub 2013 Sep 18.


Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex.

Liu X, Main D, Ma Y, He B.

J Virol. 2018 Jun 29;92(14). pii: e00402-18. doi: 10.1128/JVI.00402-18. Print 2018 Jul 15.


Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.

Unterholzner L, Sumner RP, Baran M, Ren H, Mansur DS, Bourke NM, Randow F, Smith GL, Bowie AG.

PLoS Pathog. 2011 Sep;7(9):e1002247. doi: 10.1371/journal.ppat.1002247. Epub 2011 Sep 8.


IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.

McWhirter SM, Fitzgerald KA, Rosains J, Rowe DC, Golenbock DT, Maniatis T.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):233-8. Epub 2003 Dec 16.


DOK3 is required for IFN-β production by enabling TRAF3/TBK1 complex formation and IRF3 activation.

Kim SS, Lee KG, Chin CS, Ng SK, Pereira NA, Xu S, Lam KP.

J Immunol. 2014 Jul 15;193(2):840-8. doi: 10.4049/jimmunol.1301601. Epub 2014 Jun 13.


Phosphatase Cdc25A Negatively Regulates the Antiviral Immune Response by Inhibiting TBK1 Activity.

Qi D, Hu L, Jiao T, Zhang T, Tong X, Ye X.

J Virol. 2018 Sep 12;92(19). pii: e01118-18. doi: 10.1128/JVI.01118-18. Print 2018 Oct 1.


Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction.

Ning YJ, Feng K, Min YQ, Deng F, Hu Z, Wang H.

J Biol Chem. 2017 Oct 6;292(40):16722-16733. doi: 10.1074/jbc.M117.805127. Epub 2017 Aug 28.


Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1.

Lu LL, Puri M, Horvath CM, Sen GC.

J Biol Chem. 2008 May 23;283(21):14269-76. doi: 10.1074/jbc.M710089200. Epub 2008 Mar 24.


Hantavirus GnT elements mediate TRAF3 binding and inhibit RIG-I/TBK1-directed beta interferon transcription by blocking IRF3 phosphorylation.

Matthys VS, Cimica V, Dalrymple NA, Glennon NB, Bianco C, Mackow ER.

J Virol. 2014 Feb;88(4):2246-59. doi: 10.1128/JVI.02647-13. Epub 2014 Jan 3.


Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.

Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P.

Biochem J. 2017 Mar 15;474(7):1163-1174. doi: 10.1042/BCJ20160992.


TRIM11 negatively regulates IFNβ production and antiviral activity by targeting TBK1.

Lee Y, Song B, Park C, Kwon KS.

PLoS One. 2013 May 13;8(5):e63255. doi: 10.1371/journal.pone.0063255. Print 2013.


Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity.

Moriyama M, Igarashi M, Koshiba T, Irie T, Takada A, Ichinohe T.

J Virol. 2018 Sep 12;92(19). pii: e00706-18. doi: 10.1128/JVI.00706-18. Print 2018 Oct 1.


Mechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1).

Marion JD, Roberts CF, Call RJ, Forbes JL, Nelson KT, Bell JE, Bell JK.

J Biol Chem. 2013 Jun 21;288(25):18612-23. doi: 10.1074/jbc.M112.440859. Epub 2013 May 6.


SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity.

Liu D, Sheng C, Gao S, Yao C, Li J, Jiang W, Chen H, Wu J, Pan C, Chen S, Huang W.

Mol Cell Biol. 2015 Jul;35(14):2400-13. doi: 10.1128/MCB.00090-15. Epub 2015 May 4.

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