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Items: 1 to 20 of 129


Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs.

Broughton S, Alic N, Slack C, Bass T, Ikeya T, Vinti G, Tommasi AM, Driege Y, Hafen E, Partridge L.

PLoS One. 2008;3(11):e3721. doi: 10.1371/journal.pone.0003721. Epub 2008 Nov 13.


Molecular evolution and functional characterization of Drosophila insulin-like peptides.

Grönke S, Clarke DF, Broughton S, Andrews TD, Partridge L.

PLoS Genet. 2010 Feb 26;6(2):e1000857. doi: 10.1371/journal.pgen.1000857.


Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor.

Alic N, Hoddinott MP, Vinti G, Partridge L.

Aging Cell. 2011 Feb;10(1):137-47. doi: 10.1111/j.1474-9726.2010.00653.x.


Functional implications of Drosophila insulin-like peptides in metabolism, aging, and dietary restriction.

Kannan K, Fridell YW.

Front Physiol. 2013 Oct 16;4:288. doi: 10.3389/fphys.2013.00288. Review.


dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth.

Parisi F, Riccardo S, Zola S, Lora C, Grifoni D, Brown LM, Bellosta P.

Dev Biol. 2013 Jul 1;379(1):64-75. doi: 10.1016/j.ydbio.2013.04.008. Epub 2013 Apr 19.


dFOXO-independent effects of reduced insulin-like signaling in Drosophila.

Slack C, Giannakou ME, Foley A, Goss M, Partridge L.

Aging Cell. 2011 Oct;10(5):735-48. doi: 10.1111/j.1474-9726.2011.00707.x. Epub 2011 May 6.


Regulation of insulin-producing cells in the adult Drosophila brain via the tachykinin peptide receptor DTKR.

Birse RT, Söderberg JA, Luo J, Winther AM, Nässel DR.

J Exp Biol. 2011 Dec 15;214(Pt 24):4201-8. doi: 10.1242/jeb.062091.


Drosophila insulin-producing cells are differentially modulated by serotonin and octopamine receptors and affect social behavior.

Luo J, Lushchak OV, Goergen P, Williams MJ, Nässel DR.

PLoS One. 2014 Jun 12;9(6):e99732. doi: 10.1371/journal.pone.0099732. eCollection 2014.


DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition.

Broughton SJ, Slack C, Alic N, Metaxakis A, Bass TM, Driege Y, Partridge L.

Aging Cell. 2010 Jun;9(3):336-46. doi: 10.1111/j.1474-9726.2010.00558.x. Epub 2010 Feb 12. Erratum in: Aging Cell. 2010 Oct;9(5):930.


Nutritional Geometric Profiles of Insulin/IGF Expression in Drosophila melanogaster.

Post S, Tatar M.

PLoS One. 2016 May 12;11(5):e0155628. doi: 10.1371/journal.pone.0155628. eCollection 2016.


Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT1A receptor.

Luo J, Becnel J, Nichols CD, Nässel DR.

Cell Mol Life Sci. 2012 Feb;69(3):471-84. doi: 10.1007/s00018-011-0789-0. Epub 2011 Aug 5.


Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.

Broughton SJ, Piper MD, Ikeya T, Bass TM, Jacobson J, Driege Y, Martinez P, Hafen E, Withers DJ, Leevers SJ, Partridge L.

Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3105-10. Epub 2005 Feb 11.


Drosophila adiponectin receptor in insulin producing cells regulates glucose and lipid metabolism by controlling insulin secretion.

Kwak SJ, Hong SH, Bajracharya R, Yang SY, Lee KS, Yu K.

PLoS One. 2013 Jul 12;8(7):e68641. doi: 10.1371/journal.pone.0068641. Print 2013.


SLOB, a SLOWPOKE channel binding protein, regulates insulin pathway signaling and metabolism in Drosophila.

Sheldon AL, Zhang J, Fei H, Levitan IB.

PLoS One. 2011;6(8):e23343. doi: 10.1371/journal.pone.0023343. Epub 2011 Aug 5.


Drosophila germ-line modulation of insulin signaling and lifespan.

Flatt T, Min KJ, D'Alterio C, Villa-Cuesta E, Cumbers J, Lehmann R, Jones DL, Tatar M.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6368-73. doi: 10.1073/pnas.0709128105. Epub 2008 Apr 23.


Insulin signalling regulates remating in female Drosophila.

Wigby S, Slack C, Grönke S, Martinez P, Calboli FC, Chapman T, Partridge L.

Proc Biol Sci. 2011 Feb 7;278(1704):424-31. doi: 10.1098/rspb.2010.1390. Epub 2010 Aug 25.


Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin.

Kapan N, Lushchak OV, Luo J, Nässel DR.

Cell Mol Life Sci. 2012 Dec;69(23):4051-66. doi: 10.1007/s00018-012-1097-z. Epub 2012 Jul 25.


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