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Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.

Joshi I, Minter LM, Telfer J, Demarest RM, Capobianco AJ, Aster JC, Sicinski P, Fauq A, Golde TE, Osborne BA.

Blood. 2009 Feb 19;113(8):1689-98. doi: 10.1182/blood-2008-03-147967. Epub 2008 Nov 10.


Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

Rao SS, O'Neil J, Liberator CD, Hardwick JS, Dai X, Zhang T, Tyminski E, Yuan J, Kohl NE, Richon VM, Van der Ploeg LH, Carroll PM, Draetta GF, Look AT, Strack PR, Winter CG.

Cancer Res. 2009 Apr 1;69(7):3060-8. doi: 10.1158/0008-5472.CAN-08-4295. Epub 2009 Mar 24.


KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo.

Pekkonen P, Järviluoma A, Zinovkina N, Cvrljevic A, Prakash S, Westermarck J, Evan GI, Cesarman E, Verschuren EW, Ojala PM.

Cell Cycle. 2014;13(23):3670-84. doi: 10.4161/15384101.2014.964118.


Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes.

Solvason N, Wu WW, Kabra N, Wu X, Lees E, Howard MC.

J Exp Med. 1996 Aug 1;184(2):407-17.


NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications.

Clementz AG, Rogowski A, Pandya K, Miele L, Osipo C.

Breast Cancer Res. 2011 Jun 14;13(3):R63. doi: 10.1186/bcr2900.


Cyclin D3 is dispensable for human diffuse large B-cell lymphoma survival and growth: evidence for redundancy with cyclin E.

Gumina MR, Xu C, Chiles TC.

Cell Cycle. 2010 Feb 15;9(4):820-8. Epub 2010 Mar 2.


Notch1 signaling regulates the proliferation and self-renewal of human dental follicle cells by modulating the G1/S phase transition and telomerase activity.

Chen X, Zhang T, Shi J, Xu P, Gu Z, Sandham A, Yang L, Ye Q.

PLoS One. 2013 Jul 29;8(7):e69967. doi: 10.1371/journal.pone.0069967. Print 2013.


Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression.

Noseda M, Chang L, McLean G, Grim JE, Clurman BE, Smith LL, Karsan A.

Mol Cell Biol. 2004 Oct;24(20):8813-22.


Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia.

Wang L, Wang J, Blaser BW, Duchemin AM, Kusewitt DF, Liu T, Caligiuri MA, Briesewitz R.

Blood. 2007 Sep 15;110(6):2075-83. Epub 2007 May 30.


Cyclin D3 expression in melanoma cells is regulated by adhesion-dependent phosphatidylinositol 3-kinase signaling and contributes to G1-S progression.

Spofford LS, Abel EV, Boisvert-Adamo K, Aplin AE.

J Biol Chem. 2006 Sep 1;281(35):25644-51. Epub 2006 Jun 29.


New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.

Hales EC, Taub JW, Matherly LH.

Cell Signal. 2014 Jan;26(1):149-61. doi: 10.1016/j.cellsig.2013.09.021. Epub 2013 Oct 16. Review.


Cell cycle exit during terminal erythroid differentiation is associated with accumulation of p27(Kip1) and inactivation of cdk2 kinase.

Hsieh FF, Barnett LA, Green WF, Freedman K, Matushansky I, Skoultchi AI, Kelley LL.

Blood. 2000 Oct 15;96(8):2746-54.


Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.

Srethapakdi M, Liu F, Tavorath R, Rosen N.

Cancer Res. 2000 Jul 15;60(14):3940-6.


Cyclic AMP-dependent phosphorylation of cyclin D3-bound CDK4 determines the passage through the cell cycle restriction point in thyroid epithelial cells.

Paternot S, Coulonval K, Dumont JE, Roger PP.

J Biol Chem. 2003 Jul 18;278(29):26533-40. Epub 2003 Apr 30.


Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.

Sawai CM, Freund J, Oh P, Ndiaye-Lobry D, Bretz JC, Strikoudis A, Genesca L, Trimarchi T, Kelliher MA, Clark M, Soulier J, Chen-Kiang S, Aifantis I.

Cancer Cell. 2012 Oct 16;22(4):452-65. doi: 10.1016/j.ccr.2012.09.016.


cAMP-mediated growth inhibition of lymphoid cells in G1: rapid down-regulation of cyclin D3 at the level of translation.

Naderi S, Gützkow KB, Christoffersen J, Smeland EB, Blomhoff HK.

Eur J Immunol. 2000 Jun;30(6):1757-68.

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