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Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy.

Mallinson JE, Constantin-Teodosiu D, Sidaway J, Westwood FR, Greenhaff PL.

J Physiol. 2009 Jan 15;587(1):219-30. doi: 10.1113/jphysiol.2008.164699. Epub 2008 Nov 10.


Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.

Mallinson JE, Constantin-Teodosiu D, Glaves PD, Martin EA, Davies WJ, Westwood FR, Sidaway JE, Greenhaff PL.

J Physiol. 2012 Dec 15;590(24):6389-402. doi: 10.1113/jphysiol.2012.238022. Epub 2012 Oct 8.


A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle.

Crossland H, Constantin-Teodosiu D, Gardiner SM, Constantin D, Greenhaff PL.

J Physiol. 2008 Nov 15;586(22):5589-600. doi: 10.1113/jphysiol.2008.160150. Epub 2008 Sep 25.


Electrostimulation during hindlimb unloading modulates PI3K-AKT downstream targets without preventing soleus atrophy and restores slow phenotype through ERK.

Dupont E, Cieniewski-Bernard C, Bastide B, Stevens L.

Am J Physiol Regul Integr Comp Physiol. 2011 Feb;300(2):R408-17. doi: 10.1152/ajpregu.00793.2009. Epub 2010 Nov 24.


Low-dose dexamethasone prevents endotoxaemia-induced muscle protein loss and impairment of carbohydrate oxidation in rat skeletal muscle.

Crossland H, Constantin-Teodosiu D, Greenhaff PL, Gardiner SM.

J Physiol. 2010 Apr 15;588(Pt 8):1333-47. doi: 10.1113/jphysiol.2009.183699. Epub 2010 Feb 22.


Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling.

McClung JM, Kavazis AN, Whidden MA, DeRuisseau KC, Falk DJ, Criswell DS, Powers SK.

J Physiol. 2007 Nov 15;585(Pt 1):203-15. Epub 2007 Oct 4.


Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury.

Wu H, Lu D, Jiang H, Xiong Y, Qu C, Li B, Mahmood A, Zhou D, Chopp M.

J Neurosurg. 2008 Oct;109(4):691-8. doi: 10.3171/JNS/2008/109/10/0691.


The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity.

Bonifacio A, Sanvee GM, Bouitbir J, Krähenbühl S.

Biochim Biophys Acta. 2015 Aug;1853(8):1841-9. doi: 10.1016/j.bbamcr.2015.04.010. Epub 2015 Apr 23.


Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro.

Brand Y, Setz C, Levano S, Listyo A, Chavez E, Pak K, Sung M, Radojevic V, Ryan AF, Bodmer D.

BMC Neurosci. 2011 Nov 14;12:114. doi: 10.1186/1471-2202-12-114.


PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle.

Constantin D, Constantin-Teodosiu D, Layfield R, Tsintzas K, Bennett AJ, Greenhaff PL.

J Physiol. 2007 Aug 15;583(Pt 1):381-90. Epub 2007 May 31.


Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo.

Bonifacio A, Mullen PJ, Mityko IS, Navegantes LC, Bouitbir J, Krähenbühl S.

Arch Toxicol. 2016 Jan;90(1):203-15. doi: 10.1007/s00204-014-1378-4. Epub 2014 Oct 10.


Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy.

Mullen PJ, Lüscher B, Scharnagl H, Krähenbühl S, Brecht K.

Biochem Pharmacol. 2010 Apr 15;79(8):1200-9. doi: 10.1016/j.bcp.2009.12.007. Epub 2009 Dec 14.


Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in response to formoterol administration in rat skeletal muscle.

Joassard OR, Amirouche A, Gallot YS, Desgeorges MM, Castells J, Durieux AC, Berthon P, Freyssenet DG.

Int J Biochem Cell Biol. 2013 Nov;45(11):2444-55. doi: 10.1016/j.biocel.2013.07.019. Epub 2013 Aug 2.


The increase in cardiac pyruvate dehydrogenase kinase-4 after short-term dexamethasone is controlled by an Akt-p38-forkhead box other factor-1 signaling axis.

Puthanveetil P, Wang Y, Wang F, Kim MS, Abrahani A, Rodrigues B.

Endocrinology. 2010 May;151(5):2306-18. doi: 10.1210/en.2009-1072. Epub 2010 Feb 24.


Statin-induced myopathy in the rat: relationship between systemic exposure, muscle exposure and myopathy.

Sidaway J, Wang Y, Marsden AM, Orton TC, Westwood FR, Azuma CT, Scott RC.

Xenobiotica. 2009 Jan;39(1):90-8. doi: 10.1080/00498250802585539 .


Effect of estrogen and inhibition of phosphatidylinositol-3 kinase on Akt and FOXO1 in rat uterus.

Lengyel F, Vértes Z, Kovács KA, Környei JL, Sümegi B, Vértes M.

Steroids. 2007 May;72(5):422-8. Epub 2007 Mar 12.


Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A.

Mol Cell. 2008 Oct 24;32(2):221-31. doi: 10.1016/j.molcel.2008.09.013.


Insulin suppresses atrophy- and autophagy-related genes in heart tissue and cardiomyocytes through AKT/FOXO signaling.

Paula-Gomes S, Gonçalves DA, Baviera AM, Zanon NM, Navegantes LC, Kettelhut IC.

Horm Metab Res. 2013 Nov;45(12):849-55. doi: 10.1055/s-0033-1347209. Epub 2013 Jun 11.


Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content.

Goodman CA, Pol D, Zacharewicz E, Lee-Young RS, Snow RJ, Russell AP, McConell GK.

PLoS One. 2015 May 28;10(5):e0128398. doi: 10.1371/journal.pone.0128398. eCollection 2015.


Rosuvastatin: characterization of induced myopathy in the rat.

Westwood FR, Scott RC, Marsden AM, Bigley A, Randall K.

Toxicol Pathol. 2008 Feb;36(2):345-52. doi: 10.1177/0192623307311412. Epub 2008 Mar 24.


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