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Items: 1 to 20 of 137


Mitochondrial and sarcoplasmic protein changes in hearts from copper-deficient rats: up-regulation of PGC-1alpha transcript and protein as a cause for mitochondrial biogenesis in copper deficiency.

Medeiros DM, Jiang Y, Klaahsen D, Lin D.

J Nutr Biochem. 2009 Oct;20(10):823-30. doi: 10.1016/j.jnutbio.2008.08.001. Epub 2008 Nov 6.


Myocardial infarction in rats causes partial impairment in insulin response associated with reduced fatty acid oxidation and mitochondrial gene expression.

Amorim PA, Nguyen TD, Shingu Y, Schwarzer M, Mohr FW, Schrepper A, Doenst T.

J Thorac Cardiovasc Surg. 2010 Nov;140(5):1160-7. doi: 10.1016/j.jtcvs.2010.08.003. Epub 2010 Sep 17.


Roles of transcriptional corepressor RIP140 and coactivator PGC-1α in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytes.

Chen Y, Wang Y, Chen J, Chen X, Cao W, Chen S, Xu S, Huang H, Liu P.

Mol Cell Endocrinol. 2012 Oct 15;362(1-2):11-8. doi: 10.1016/j.mce.2012.03.023. Epub 2012 Apr 5.


Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1α pathway.

Sun L, Zhao M, Yu XJ, Wang H, He X, Liu JK, Zang WJ.

J Cell Physiol. 2013 Jun;228(6):1238-48. doi: 10.1002/jcp.24277.


Peroxisome proliferator activated receptor alpha (PPARalpha) and PPAR gamma coactivator (PGC-1alpha) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements.

Song S, Attia RR, Connaughton S, Niesen MI, Ness GC, Elam MB, Hori RT, Cook GA, Park EA.

Mol Cell Endocrinol. 2010 Aug 30;325(1-2):54-63. doi: 10.1016/j.mce.2010.05.019.


Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression.

Wright DC, Han DH, Garcia-Roves PM, Geiger PC, Jones TE, Holloszy JO.

J Biol Chem. 2007 Jan 5;282(1):194-9. Epub 2006 Nov 12.


Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1α by PRMT1 and SIRT1.

Garcia MM, Guéant-Rodriguez RM, Pooya S, Brachet P, Alberto JM, Jeannesson E, Maskali F, Gueguen N, Marie PY, Lacolley P, Herrmann M, Juillière Y, Malthiery Y, Guéant JL.

J Pathol. 2011 Nov;225(3):324-35. doi: 10.1002/path.2881. Epub 2011 Jun 1.


Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training.

Derbré F, Gomez-Cabrera MC, Nascimento AL, Sanchis-Gomar F, Martinez-Bello VE, Tresguerres JA, Fuentes T, Gratas-Delamarche A, Monsalve M, Viña J.

Age (Dordr). 2012 Jun;34(3):669-79. doi: 10.1007/s11357-011-9264-y. Epub 2011 May 18.


High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα-FoxO3a-PGC-1α pathway.

Chung HW, Lim JH, Kim MY, Shin SJ, Chung S, Choi BS, Kim HW, Kim YS, Park CW, Chang YS.

Nephrol Dial Transplant. 2012 Jun;27(6):2213-25. doi: 10.1093/ndt/gfr613. Epub 2011 Nov 9.


The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism.

Yubero P, Hondares E, Carmona MC, Rossell M, Gonzalez FJ, Iglesias R, Giralt M, Villarroya F.

Endocrinology. 2004 Sep;145(9):4268-77. Epub 2004 Jun 3.


A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth.

Martin OJ, Lai L, Soundarapandian MM, Leone TC, Zorzano A, Keller MP, Attie AD, Muoio DM, Kelly DP.

Circ Res. 2014 Feb 14;114(4):626-36. doi: 10.1161/CIRCRESAHA.114.302562. Epub 2013 Dec 23.


Inhibition of cardiac PGC-1alpha expression abolishes ERbeta agonist-mediated cardioprotection following trauma-hemorrhage.

Hsieh YC, Choudhry MA, Yu HP, Shimizu T, Yang S, Suzuki T, Chen J, Bland KI, Chaudry IH.

FASEB J. 2006 Jun;20(8):1109-17.


Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α.

Zhu Y, Soto J, Anderson B, Riehle C, Zhang YC, Wende AR, Jones D, McClain DA, Abel ED.

Am J Physiol Heart Circ Physiol. 2013 Jul 1;305(1):H41-51. doi: 10.1152/ajpheart.00877.2012. Epub 2013 Apr 26.


Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria.

Benton CR, Nickerson JG, Lally J, Han XX, Holloway GP, Glatz JF, Luiken JJ, Graham TE, Heikkila JJ, Bonen A.

J Biol Chem. 2008 Feb 15;283(7):4228-40. Epub 2007 Dec 12.


Downregulation of peroxisme proliferator activated receptor gamma co-activator 1alpha in diabetic rats.

Chang LT, Sun CK, Wang CY, Youssef AA, Wu CJ, Chua S, Yip HK.

Int Heart J. 2006 Nov;47(6):901-10.


PGC-1alpha and PGC-1beta have both similar and distinct effects on myofiber switching toward an oxidative phenotype.

Mortensen OH, Frandsen L, Schjerling P, Nishimura E, Grunnet N.

Am J Physiol Endocrinol Metab. 2006 Oct;291(4):E807-16. Epub 2006 May 23.


Genomic and non-genomic regulation of PGC1 isoforms by estrogen to increase cerebral vascular mitochondrial biogenesis and reactive oxygen species protection.

Kemper MF, Stirone C, Krause DN, Duckles SP, Procaccio V.

Eur J Pharmacol. 2014 Jan 15;723:322-9. doi: 10.1016/j.ejphar.2013.11.009. Epub 2013 Nov 22.


The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis.

Gurd BJ, Yoshida Y, Lally J, Holloway GP, Bonen A.

J Physiol. 2009 Apr 15;587(Pt 8):1817-28. doi: 10.1113/jphysiol.2008.168096. Epub 2009 Feb 23.

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