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Items: 1 to 20 of 261

1.

Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes.

Acikgöz A, Karim N, Giri S, Schmidt-Heck W, Bader A.

Toxicol Appl Pharmacol. 2009 Jan 15;234(2):179-91. doi: 10.1016/j.taap.2008.09.029. Epub 2008 Oct 15.

PMID:
18983865
2.

Biotransformation of diazepam in a clinically relevant flat membrane bioreactor model using primary porcine hepatocytes.

Maringka M, Giri S, Nieber K, Acikgöz A, Bader A.

Fundam Clin Pharmacol. 2011 Jun;25(3):343-53. doi: 10.1111/j.1472-8206.2010.00857.x.

PMID:
20618872
3.

Metabolism of diazepam in vitro by human liver. Independent variability of N-demethylation and C3-hydroxylation.

Inaba T, Tait A, Nakano M, Mahon WA, Kalow W.

Drug Metab Dispos. 1988 Jul-Aug;16(4):605-8.

PMID:
2903030
4.

In vitro drug metabolism and pharmacokinetics of diazepam in cynomolgus monkey hepatocytes during culture for six days.

Seddon T, Lockwood GF, Chenery RJ.

Biochem Pharmacol. 1989 Aug 15;38(16):2621-30.

PMID:
2504170
5.
6.

Concentration-dependent metabolism of diazepam in mouse liver.

St-Pierre MV, Pang KS.

J Pharmacokinet Biopharm. 1995 Jun;23(3):243-66.

PMID:
8834195
7.
8.

Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms.

Andersson T, Miners JO, Veronese ME, Birkett DJ.

Br J Clin Pharmacol. 1994 Aug;38(2):131-7.

10.

The simultaneous determination of diazepam and its three metabolites in dog plasma by high-performance liquid chromatography with mass spectroscopy detection.

Liu Z, Short J, Rose A, Ren S, Contel N, Grossman S, Unger S.

J Pharm Biomed Anal. 2001 Sep;26(2):321-30.

PMID:
11470209
11.
12.

Inhibition of diazepam metabolism in microsomal- and perfused liver preparations of the rat by desmethyldiazepam, N-methyloxazepam and oxazepam.

Savenije-Chapel EM, Bast A, Noordhoek J.

Eur J Drug Metab Pharmacokinet. 1985 Jan-Mar;10(1):15-20.

PMID:
2863150
13.

Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes.

Szotáková B, Skálová L, Baliharová V, Dvorscáková M, Storkánová L, Sispera L, Wsól V.

J Pharm Pharmacol. 2004 Feb;56(2):205-12.

PMID:
15005879
14.

The quantitative prediction of in vivo enzyme-induction caused by drug exposure from in vitro information on human hepatocytes.

Kato M, Chiba K, Horikawa M, Sugiyama Y.

Drug Metab Pharmacokinet. 2005 Aug;20(4):236-43.

15.

CYP3A inductive potential of the rifamycins, rifabutin and rifampin, in the rabbit.

Weber A, Kaplan M, Chughtai SA, Cohn LA, Smith AL, Unadkat JD.

Biopharm Drug Dispos. 2001 May;22(4):157-68.

PMID:
11745918
16.

Absorption of diazepam after its rectal administration in dogs.

Papich MG, Alcorn J.

Am J Vet Res. 1995 Dec;56(12):1629-36.

PMID:
8599525
17.

Effect of enzyme induction on Sandimmun (cyclosporin A) biotransformation and hepatotoxicity in cultured rat hepatocytes and in vivo.

Bouis P, Brouillard JF, Fischer V, Donatsch P, Boelsterli UA.

Biochem Pharmacol. 1990 Jan 15;39(2):257-66.

PMID:
2105730
18.

Development and preliminary application of high-performance liquid chromatographic assay of urinary metabolites of diazepam in humans.

Chiba K, Horii H, Chiba T, Kato Y, Hirano T, Ishizaki T.

J Chromatogr B Biomed Appl. 1995 Jun 9;668(1):77-84.

PMID:
7550984
19.

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