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Items: 1 to 20 of 76

1.

IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA.

Mortimer SE, Xu D, McGrew D, Hamaguchi N, Lim HC, Bowne SJ, Daiger SP, Hedstrom L.

J Biol Chem. 2008 Dec 26;283(52):36354-60. doi: 10.1074/jbc.M806143200. Epub 2008 Oct 30.

2.

Towards a pathological mechanism for IMPDH1-linked retinitis pigmentosa.

McGrew DA, Hedstrom L.

Adv Exp Med Biol. 2012;723:539-45. doi: 10.1007/978-1-4614-0631-0_68. Review.

PMID:
22183375
3.

Different characteristics and nucleotide binding properties of inosine monophosphate dehydrogenase (IMPDH) isoforms.

Thomas EC, Gunter JH, Webster JA, Schieber NL, Oorschot V, Parton RG, Whitehead JP.

PLoS One. 2012;7(12):e51096. doi: 10.1371/journal.pone.0051096. Epub 2012 Dec 7.

4.

Why do mutations in the ubiquitously expressed housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration?

Bowne SJ, Liu Q, Sullivan LS, Zhu J, Spellicy CJ, Rickman CB, Pierce EA, Daiger SP.

Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3754-65.

5.

Retinal isoforms of inosine 5'-monophosphate dehydrogenase type 1 are poor nucleic acid binding proteins.

Xu D, Cobb G, Spellicy CJ, Bowne SJ, Daiger SP, Hedstrom L.

Arch Biochem Biophys. 2008 Apr 15;472(2):100-4. doi: 10.1016/j.abb.2008.02.012. Epub 2008 Feb 14.

6.

On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa.

Aherne A, Kennan A, Kenna PF, McNally N, Lloyd DG, Alberts IL, Kiang AS, Humphries MM, Ayuso C, Engel PC, Gu JJ, Mitchell BS, Farrar GJ, Humphries P.

Hum Mol Genet. 2004 Mar 15;13(6):641-50.

PMID:
14981049
7.

IMP dehydrogenase-linked retinitis pigmentosa.

Hedstrom L.

Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):839-49. doi: 10.1080/15257770802146486. Review.

PMID:
18600550
8.

Characterization of retinal inosine monophosphate dehydrogenase 1 in several mammalian species.

Spellicy CJ, Daiger SP, Sullivan LS, Zhu J, Liu Q, Pierce EA, Bowne SJ.

Mol Vis. 2007 Oct 3;13:1866-72.

PMID:
17960124
9.

On the role of IMPDH1 in retinal degeneration.

Kennan A, Aherne A, Bowne SJ, Daiger SP, Farrar GJ, Kenna PF, Humphries P.

Adv Exp Med Biol. 2003;533:13-8. No abstract available.

10.

Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10).

Tam LC, Kiang AS, Kennan A, Kenna PF, Chadderton N, Ader M, Palfi A, Aherne A, Ayuso C, Campbell M, Reynolds A, McKee A, Humphries MM, Farrar GJ, Humphries P.

Hum Mol Genet. 2008 Jul 15;17(14):2084-100. doi: 10.1093/hmg/ddn107. Epub 2008 Apr 1.

PMID:
18385099
11.

Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90).

Tam LC, Kiang AS, Campbell M, Keaney J, Farrar GJ, Humphries MM, Kenna PF, Humphries P.

Hum Mol Genet. 2010 Nov 15;19(22):4421-36. doi: 10.1093/hmg/ddq369. Epub 2010 Sep 2.

12.

Regulation of inosine monophosphate dehydrogenase type I and type II isoforms in human lymphocytes.

Jain J, Almquist SJ, Ford PJ, Shlyakhter D, Wang Y, Nimmesgern E, Germann UA.

Biochem Pharmacol. 2004 Feb 15;67(4):767-76.

PMID:
14757177
13.

Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6.

McMillan FM, Cahoon M, White A, Hedstrom L, Petsko GA, Ringe D.

Biochemistry. 2000 Apr 18;39(15):4533-42.

PMID:
10758003
14.

Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho(-/-) mice.

Kennan A, Aherne A, Palfi A, Humphries M, McKee A, Stitt A, Simpson DA, Demtroder K, Orntoft T, Ayuso C, Kenna PF, Farrar GJ, Humphries P.

Hum Mol Genet. 2002 Mar 1;11(5):547-57.

PMID:
11875049
15.

A regulatory role of the Bateman domain of IMP dehydrogenase in adenylate nucleotide biosynthesis.

Pimkin M, Pimkina J, Markham GD.

J Biol Chem. 2009 Mar 20;284(12):7960-9. doi: 10.1074/jbc.M808541200. Epub 2009 Jan 18.

16.

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation.

Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H.

Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1890-9. doi: 10.1107/S1399004715013115. Epub 2015 Aug 25.

PMID:
26327379
17.

Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo.

McLean JE, Hamaguchi N, Belenky P, Mortimer SE, Stanton M, Hedstrom L.

Biochem J. 2004 Apr 15;379(Pt 2):243-51.

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