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HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase.

Durkin SS, Guo X, Fryrear KA, Mihaylova VT, Gupta SK, Belgnaoui SM, Haoudi A, Kupfer GM, Semmes OJ.

J Biol Chem. 2008 Dec 26;283(52):36311-20. doi: 10.1074/jbc.M804931200. Epub 2008 Oct 27.


The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin.

Belgnaoui SM, Fryrear KA, Nyalwidhe JO, Guo X, Semmes OJ.

J Biol Chem. 2010 Oct 22;285(43):32897-905. doi: 10.1074/jbc.M110.146373. Epub 2010 Aug 20.


Human T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2.

Gupta SK, Guo X, Durkin SS, Fryrear KF, Ward MD, Semmes OJ.

J Biol Chem. 2007 Oct 5;282(40):29431-40. Epub 2007 Aug 13.


Human T-cell leukemia virus-I tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response.

Haoudi A, Daniels RC, Wong E, Kupfer G, Semmes OJ.

J Biol Chem. 2003 Sep 26;278(39):37736-44. Epub 2003 Jul 2.


Regulation of CHK2 by DNA-dependent protein kinase.

Li J, Stern DF.

J Biol Chem. 2005 Mar 25;280(12):12041-50. Epub 2005 Jan 24.


DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.

Drouet J, Delteil C, Lefran├žois J, Concannon P, Salles B, Calsou P.

J Biol Chem. 2005 Feb 25;280(8):7060-9. Epub 2004 Oct 31.


DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.

Douglas P, Gupta S, Morrice N, Meek K, Lees-Miller SP.

DNA Repair (Amst). 2005 Aug 15;4(9):1006-18.


Protein phosphatases regulate DNA-dependent protein kinase activity.

Douglas P, Moorhead GB, Ye R, Lees-Miller SP.

J Biol Chem. 2001 Jun 1;276(22):18992-8. Epub 2001 Mar 16.


Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response.

Chandhasin C, Ducu RI, Berkovich E, Kastan MB, Marriott SJ.

J Virol. 2008 Jul;82(14):6952-61. doi: 10.1128/JVI.02331-07. Epub 2008 Apr 23.


The DNA-PK catalytic subunit regulates Bax-mediated excitotoxic cell death by Ku70 phosphorylation.

Liu J, Naegele JR, Lin SL.

Brain Res. 2009 Nov 3;1296:164-75. doi: 10.1016/j.brainres.2009.07.101. Epub 2009 Aug 4.


Role of DNA-dependent protein kinase in recognition of radiation-induced DNA damage in human peripheral blood mononuclear cells.

Frasca D, Barattini P, Tocchi G, Guidi L, Pierelli L, Doria G.

Int Immunol. 2001 Jun;13(6):791-7.


Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways.

Solier S, Sordet O, Kohn KW, Pommier Y.

Mol Cell Biol. 2009 Jan;29(1):68-82. doi: 10.1128/MCB.00581-08. Epub 2008 Oct 27.


Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.

Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC.

Mol Cell Biol. 1998 Sep;18(9):5157-65.


The HTLV-1 Tax oncoprotein represses Ku80 gene expression.

Ducu RI, Dayaram T, Marriott SJ.

Virology. 2011 Jul 20;416(1-2):1-8. doi: 10.1016/j.virol.2011.04.012. Epub 2011 May 14.


The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation.

Merkle D, Douglas P, Moorhead GB, Leonenko Z, Yu Y, Cramb D, Bazett-Jones DP, Lees-Miller SP.

Biochemistry. 2002 Oct 22;41(42):12706-14.


Human T-cell leukemia virus type 1 Tax attenuates gamma-irradiation-induced apoptosis through physical interaction with Chk2.

Park HU, Jeong SJ, Jeong JH, Chung JH, Brady JN.

Oncogene. 2006 Jan 19;25(3):438-47.


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