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Items: 1 to 20 of 200

1.

Leishmania infantum expresses a mitochondrial nuclease homologous to EndoG that migrates to the nucleus in response to an apoptotic stimulus.

Rico E, Alzate JF, Arias AA, Moreno D, Clos J, Gago F, Moreno I, Domínguez M, Jiménez-Ruiz A.

Mol Biochem Parasitol. 2009 Jan;163(1):28-38. doi: 10.1016/j.molbiopara.2008.09.007. Epub 2008 Oct 2.

PMID:
18940204
2.

Conservation of the pro-apoptotic nuclease activity of endonuclease G in unicellular trypanosomatid parasites.

Gannavaram S, Vedvyas C, Debrabant A.

J Cell Sci. 2008 Jan 1;121(Pt 1):99-109. Epub 2007 Dec 11.

3.

Structural and functional characterization of mitochondrial EndoG, a sugar non-specific nuclease which plays an important role during apoptosis.

Schäfer P, Scholz SR, Gimadutdinow O, Cymerman IA, Bujnicki JM, Ruiz-Carrillo A, Pingoud A, Meiss G.

J Mol Biol. 2004 Apr 23;338(2):217-28.

PMID:
15066427
4.

Structure-based domain assignment in Leishmania infantum EndoG: characterization of a pH-dependent regulatory switch and a C-terminal extension that largely dictates DNA substrate preferences.

Oliva C, Sánchez-Murcia PA, Rico E, Bravo A, Menéndez M, Gago F, Jiménez-Ruiz A.

Nucleic Acids Res. 2017 Sep 6;45(15):9030-9045. doi: 10.1093/nar/gkx629.

5.

Leishmania infantum EndoG is an endo/exo-nuclease essential for parasite survival.

Rico E, Oliva C, Gutierrez KJ, Alzate JF, Genes CM, Moreno D, Casanova E, Gigante A, Pérez-Pérez MJ, Camarasa MJ, Clos J, Gago F, Jiménez-Ruiz A.

PLoS One. 2014 Feb 26;9(2):e89526. doi: 10.1371/journal.pone.0089526. eCollection 2014.

6.

Endonuclease G is an apoptotic DNase when released from mitochondria.

Li LY, Luo X, Wang X.

Nature. 2001 Jul 5;412(6842):95-9.

PMID:
11452314
7.

EndoG is dispensable in embryogenesis and apoptosis.

David KK, Sasaki M, Yu SW, Dawson TM, Dawson VL.

Cell Death Differ. 2006 Jul;13(7):1147-55. Epub 2005 Oct 21.

8.

Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity.

Castro H, Romao S, Carvalho S, Teixeira F, Sousa C, Tomás AM.

PLoS One. 2010 Sep 8;5(9):e12607. doi: 10.1371/journal.pone.0012607.

9.

Endonuclease G regulates budding yeast life and death.

Büttner S, Eisenberg T, Carmona-Gutierrez D, Ruli D, Knauer H, Ruckenstuhl C, Sigrist C, Wissing S, Kollroser M, Fröhlich KU, Sigrist S, Madeo F.

Mol Cell. 2007 Jan 26;25(2):233-46.

10.

Heat-induced programmed cell death in Leishmania infantum is reverted by Bcl-X(L) expression.

Alzate JF, Alvarez-Barrientos A, González VM, Jiménez-Ruiz A.

Apoptosis. 2006 Feb;11(2):161-71.

PMID:
16502255
11.

Mitochondrial superoxide mediates heat-induced apoptotic-like death in Leishmania infantum.

Alzate JF, Arias AA, Moreno-Mateos D, Alvarez-Barrientos A, Jiménez-Ruiz A.

Mol Biochem Parasitol. 2007 Apr;152(2):192-202. Epub 2007 Jan 9.

PMID:
17300844
12.

Stage-specific expression of the glycine cleavage complex subunits in Leishmania infantum.

Müller M, Papadopoulou B.

Mol Biochem Parasitol. 2010 Mar;170(1):17-27. doi: 10.1016/j.molbiopara.2009.11.009. Epub 2009 Dec 2.

PMID:
19961881
13.

Involvement of endonuclease G in nucleosomal DNA fragmentation under sustained endogenous oxidative stress.

Ishihara Y, Shimamoto N.

J Biol Chem. 2006 Mar 10;281(10):6726-33. Epub 2006 Jan 4.

14.

Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation.

Zhao ST, Chen M, Li SJ, Zhang MH, Li BX, Das M, Bean JC, Kong JM, Zhu XH, Gao TM.

BMC Neurosci. 2009 Sep 8;10:113. doi: 10.1186/1471-2202-10-113.

15.

The caspase-independent algorithm of programmed cell death in Leishmania induced by baicalein: the role of LdEndoG, LdFEN-1 and LdTatD as a DNA 'degradesome'.

BoseDasgupta S, Das BB, Sengupta S, Ganguly A, Roy A, Dey S, Tripathi G, Dinda B, Majumder HK.

Cell Death Differ. 2008 Oct;15(10):1629-40. doi: 10.1038/cdd.2008.85. Epub 2008 Jun 20.

16.

A combined proteomic and transcriptomic approach to the study of stage differentiation in Leishmania infantum.

McNicoll F, Drummelsmith J, Müller M, Madore E, Boilard N, Ouellette M, Papadopoulou B.

Proteomics. 2006 Jun;6(12):3567-81.

PMID:
16705753
17.

The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation.

Gazanion E, Garcia D, Silvestre R, Gérard C, Guichou JF, Labesse G, Seveno M, Cordeiro-Da-Silva A, Ouaissi A, Sereno D, Vergnes B.

Mol Microbiol. 2011 Oct;82(1):21-38. doi: 10.1111/j.1365-2958.2011.07799.x. Epub 2011 Sep 1.

18.

Involvement of TatD nuclease during programmed cell death in the protozoan parasite Trypanosoma brucei.

Gannavaram S, Debrabant A.

Mol Microbiol. 2012 Mar;83(5):926-35. doi: 10.1111/j.1365-2958.2012.07978.x. Epub 2012 Jan 31.

19.

5'-Trityl-substituted thymidine derivatives as a novel class of antileishmanial agents: Leishmania infantum EndoG as a potential target.

Casanova E, Moreno D, Gigante A, Rico E, Genes CM, Oliva C, Camarasa MJ, Gago F, Jiménez-Ruiz A, Pérez-Pérez MJ.

ChemMedChem. 2013 Jul;8(7):1161-74. doi: 10.1002/cmdc.201300129. Epub 2013 Apr 26.

PMID:
23625887
20.

Stage-specific antileishmanial activity of an inhibitor of SIR2 histone deacetylase.

Vergnes B, Vanhille L, Ouaissi A, Sereno D.

Acta Trop. 2005 May;94(2):107-15. Epub 2005 Apr 26.

PMID:
15860278

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