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18938236,19540127,18818047,18053326,18304528,19947169,20656007,18717331,11976833,20724170,18283591,17637197,14713364,16499877,12904281,18845169,11749795,19036441,17709137,22450134,22101374,7562498,19606017,7668104,16544145,21843940,22812001,21775093,16406853,18479598,15667829,8758912,7476894,15285852,11707575,18059532,18358092,11245485,15967469,20088680,11396162,19302234,16038636,21402141,11775252,25464884,7733620,18430371,10850444,22088467,20148593,16142320,17152486,16410038,18717489,18222670,16158930,11144235,14990067,15978189,21871878,31880526,27825801,19000450,26718439,16713148,21458446,22226881,18977528,12677527,17704658,19254348,19782062,17805981,12794765,22957792,19879873,28554760,15294447,19095404,16451059,14729595,18782542,17920233,22405646,17467965,16613670,12049484,20662321,12015084,16875558,16061283,23777360,20924640,15312340,1284834,19264847,22148475,20487225,21308736,14706144,23146037,7769842,21185854,16564522,24008321,17085341,14642128,19840447,20032409,11197207,17727798,19268700,17147248,22232851,15958061,18006147,11568932,12667316,22578055,20487633,24004004,27779650,16474189,17939402,15375375,25445037,17286965,16997518,16458258,8643093,15131592,1981310,19336892,22429509,21409205,16403271,18315901,17517188,17889544,17054045,18796331,24818584,22391167,17986257,18718061,1614407,22001531,15350632,17492365,16889754,17936633,24013575,27109742,19112920,12517780,19838926,17067671,17154505,1909515,17901905,23466342,7969041,15625765,18705753,7969046,11482878,17917879,14583495,10632321,8687117,20104851,15338873,17760250,18383825,8697970,18058609,12747785,17933543,9207946,23720244,24750961,19671415,9986718,20560605,18228136,21141501,17203756,17064079,25017650,8946933,23911883,26733176,9667951,10697518,23245571,23999162,16273216,23024026,24229684,9772674,17096884,24024664,19125251,19549365,30497065,19247716,18610751,16305951,15164094,18512984,14566676,17517470,17671737,31202598,22960326,27073052,12530010,17118775,12566319,17027968,15661399,18078134,14962729,9066699,27784359,25470220,15481991,16824763,18950875,17909680,15100388,16101136,21953821,19213345,11159798,23063551,18461970,30710850,28301155,10377220,9713509,18813811,2317255,9863176,11299755,15808402,12060530,16875600,16284790,12136248,17441731,18804944,11721384,2903793,18582150,17318783,18275843,15795098,8712686,15820092,30672437,21300536,20038517,18986763,1673636,16475720,19531378,23023936,9110922,17725099,14628443,17199425,19840446,17611700,11724282,10378008,19368123,21122352,16934756,14981526,17091771,18522868,19093883,19960428,18416942,18560226,20525557,19099628,24321342,19624024,17583464,16466920,15450947,17094479,18204840,18851949,15248030,25265513,18237469,18193112,20857089,10368688,15656144,9207950,15257929,18048888,18928592,20543467,19288491,20093732,25113878,10901303,11809535,17335117,16277030,19124148,21122348,18499486,16516478,19682879,23683834,19140665,21122354,24855835,17637191,15875665,3032411,28243063,17637500,14998330,17276076,17470401,17134887,20052473,9372859,8527996,11396174,18703276,22541076,19918367,16331495,9220975,12210557,20645795,30782299,18520065,15546712,8984151,16509594,11396135,21235729,29421572,17143487,32403017,15668728,14724945,23665114,19291609,21362214,17035027,19099191,16136961,12740176,17490878,24443428,19538007,16732933,18295490,20137116,12408767,16038730,19280878,20225656,24858801,15816562,15312359,28978268,11200506,16620573,11601045,19783433,17956668,29115592,16043202,18834355,10367565,16136308,21365663,12697126,28355069,17191263,16059735,17997939,3091555,19379565,17493334,23199479,26017567,9150713,18701045,29130339,22209486,23621869,12168720,23903006,20416163,22044878,22344570,31793054,17727795,15999537,7935339,19073909,15194484,18315902,17276690,19099507,18199465,25264278,16621244,17256837,21699084,25985578,23618585,12359358,29121121,10470152,18058680,21729536,16568474,16101031,19235584,16728344,20533270,10630360,18190907,16574387,18364123,18945821,17705442,8106146,16707254,8097673,20508289,31087712,7587718,16574265,18686787,9414394,8097964,17217917,9713492,8605275,17346076,26689174,19589678,17465195,29710665,19331851,17239597,16652192,17394131,14567677,21534039,12975485,15506297,15567248,16214115,17356823,15221508,19951528,16320588,23363222,12100750,12542364,21382175,25437111,18054347,15963465,17826829,8831775,18664392,21557331,25410120,16981729,18357372,2099412,20699436,17697617,14693053,9042237,20363142,20633549,10772630,12740641,18618115,23085022,7900978,27754360,23810952,21054396,21127835,22740937,15635865,24370495,16491453,21282948,11498864,19632288,10635304,9767651,15916428,16528529,22169288,32259795,18824363,25427107,26065532,12767063,24821111,18619958,10600530,20209493,8833064,23379426,21262330,27127131,16039989,11906965,10354400,18473435,21115910,24975508,12115804,11379779,11286477,26169035,29335204,18922976,33321149,27105294,16827137,11248673,23228414,22434582,20032393,17708791,15899526,15495829,16231181,28113128,15501994,24510559,17245652,21269564,17070665,22365753,18310046,10226171,12514799,1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Results by year

Year	Number of Results
1981	1
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915 results

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Reversal of p-glycoprotein-mediated multidrug resistance by macrocyclic bisbibenzyl derivatives in adriamycin-resistant human myelogenous leukemia (K562/A02) cells.

Li X, Sun B, Zhu CJ, Yuan HQ, Shi YQ, Gao J, Li SJ, Lou HX. Li X, et al. Toxicol In Vitro. 2009 Feb;23(1):29-36. doi: 10.1016/j.tiv.2008.09.015. Epub 2008 Oct 1. Toxicol In Vitro. 2009. PMID: 18938236

Synthesis and multidrug resistance reversal activity of dihydroptychantol A and its novel derivatives.

Sun B, Yuan HQ, Xi GM, Ma YD, Lou HX. Sun B, et al. Bioorg Med Chem. 2009 Jul 15;17(14):4981-9. doi: 10.1016/j.bmc.2009.05.077. Epub 2009 Jun 6. Bioorg Med Chem. 2009. PMID: 19540127

Reversal effect of substituted 1,3-dimethyl-1H-quinoxalin-2-ones on multidrug resistance in adriamycin-resistant K562/A02 cells.

Sun LR, Li X, Cheng YN, Yuan HY, Chen MH, Tang W, Ward SG, Qu XJ. Sun LR, et al. Biomed Pharmacother. 2009 Mar;63(3):202-8. doi: 10.1016/j.biopha.2008.07.090. Epub 2008 Aug 28. Biomed Pharmacother. 2009. PMID: 18818047

Substituted tetrahydroisoquinoline compound B3 inhibited P-glycoprotein-mediated multidrug resistance in-vitro and in-vivo.

Fang W, Li Y, Cai Y, Kang K, Yan F, Liu G, Huang W. Fang W, et al. J Pharm Pharmacol. 2007 Dec;59(12):1649-55. doi: 10.1211/jpp.59.12.0006. J Pharm Pharmacol. 2007. PMID: 18053326

Reversal effect of a macrocyclic bisbibenzyl plagiochin E on multidrug resistance in adriamycin-resistant K562/A02 cells.

Shi YQ, Qu XJ, Liao YX, Xie CF, Cheng YN, Li S, Lou HX. Shi YQ, et al. Eur J Pharmacol. 2008 Apr 14;584(1):66-71. doi: 10.1016/j.ejphar.2008.01.039. Epub 2008 Feb 5. Eur J Pharmacol. 2008. PMID: 18304528

Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.

Xu HB, Li L, Liu GQ. Xu HB, et al. Pharmazie. 2009 Oct;64(10):660-5. Pharmazie. 2009. PMID: 19947169

Reversal of P-glycoprotein-mediated multidrug resistance in vitro by milbemycin compounds in adriamycin-resistant human breast carcinoma (MCF-7/adr) cells.

Xiang W, Gao A, Liang H, Li C, Gao J, Wang Q, Shuang B, Zhang J, Yan Y, Wang X. Xiang W, et al. Toxicol In Vitro. 2010 Sep;24(6):1474-81. doi: 10.1016/j.tiv.2010.07.020. Epub 2010 Jul 23. Toxicol In Vitro. 2010. PMID: 20656007

Reversal effect of isotetrandrine, an isoquinoline alkaloid extracted from Caulis Mahoniae, on P-glycoprotein-mediated doxorubicin-resistance in human breast cancer (MCF-7/DOX) cells.

Wang TX, Yang XH. Wang TX, et al. Yao Xue Xue Bao. 2008 May;43(5):461-6. Yao Xue Xue Bao. 2008. PMID: 18717331

Induction of multidrug resistance in MOLT-4 cells by anticancer agents is closely related to increased expression of functional P-glycoprotein and MDR1 mRNA.

Liu ZL, Onda K, Tanaka S, Toma T, Hirano T, Oka K. Liu ZL, et al. Cancer Chemother Pharmacol. 2002 May;49(5):391-7. doi: 10.1007/s00280-001-0411-5. Epub 2002 Feb 14. Cancer Chemother Pharmacol. 2002. PMID: 11976833

Bisbibenzyl derivatives sensitize vincristine-resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity.

Xi GM, Sun B, Jiang HH, Kong F, Yuan HQ, Lou HX. Xi GM, et al. Bioorg Med Chem. 2010 Sep 15;18(18):6725-33. doi: 10.1016/j.bmc.2010.07.055. Epub 2010 Jul 29. Bioorg Med Chem. 2010. PMID: 20724170

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