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Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter.

Grant MA, Baron RM, Macias AA, Layne MD, Perrella MA, Rigby AC.

Biochem J. 2009 Feb 15;418(1):103-12. doi: 10.1042/BJ20081427.


Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia.

Baron RM, Carvajal IM, Liu X, Okabe RO, Fredenburgh LE, Macias AA, Chen YH, Ejima K, Layne MD, Perrella MA.

J Immunol. 2004 Sep 15;173(6):4147-53.


Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia.

Baron RM, Lopez-Guzman S, Riascos DF, Macias AA, Layne MD, Cheng G, Harris C, Chung SW, Reeves R, von Andrian UH, Perrella MA.

PLoS One. 2010 May 14;5(5):e10656. doi: 10.1371/journal.pone.0010656.


Elk-3 is a transcriptional repressor of nitric-oxide synthase 2.

Chen YH, Layne MD, Chung SW, Ejima K, Baron RM, Yet SF, Perrella MA.

J Biol Chem. 2003 Oct 10;278(41):39572-7. Epub 2003 Jul 31.


Transcriptional regulation of the HMGA1 gene by octamer-binding proteins Oct-1 and Oct-2.

Chiefari E, Arcidiacono B, Possidente K, Iiritano S, Ventura V, Pandolfo R, Brunetti FS, Greco M, Foti D, Brunetti A.

PLoS One. 2013 Dec 18;8(12):e83969. doi: 10.1371/journal.pone.0083969. eCollection 2013.


Identification of hamster inducible nitric oxide synthase (iNOS) promoter sequences that influence basal and inducible iNOS expression.

Saldarriaga OA, Travi BL, Choudhury GG, Melby PC.

J Leukoc Biol. 2012 Jul;92(1):205-18. doi: 10.1189/jlb.1010568. Epub 2012 Apr 18.


High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression.

Takamiya R, Baron RM, Yet SF, Layne MD, Perrella MA.

FEBS Lett. 2008 Mar 5;582(5):810-4. doi: 10.1016/j.febslet.2008.02.008. Epub 2008 Feb 13.


High mobility group-I(Y) protein facilitates nuclear factor-kappaB binding and transactivation of the inducible nitric-oxide synthase promoter/enhancer.

Perrella MA, Pellacani A, Wiesel P, Chin MT, Foster LC, Ibanez M, Hsieh CM, Reeves R, Yet SF, Lee ME.

J Biol Chem. 1999 Mar 26;274(13):9045-52.


Transcriptional activity of the murine retinol-binding protein gene is regulated by a multiprotein complex containing HMGA1, p54 nrb/NonO, protein-associated splicing factor (PSF) and steroidogenic factor 1 (SF1)/liver receptor homologue 1 (LRH-1).

Bianconcini A, Lupo A, Capone S, Quadro L, Monti M, Zurlo D, Fucci A, Sabatino L, Brunetti A, Chiefari E, Gottesman ME, Blaner WS, Colantuoni V.

Int J Biochem Cell Biol. 2009 Nov;41(11):2189-203. doi: 10.1016/j.biocel.2009.04.011. Epub 2009 Apr 21.


High-mobility-group A1 (HMGA1) proteins down-regulate the expression of the recombination activating gene 2 (RAG2).

Battista S, Fedele M, Martinez Hoyos J, Pentimalli F, Pierantoni GM, Visone R, De Martino I, Croce CM, Fusco A.

Biochem J. 2005 Jul 1;389(Pt 1):91-7.


RNA-Mediated Regulation of HMGA1 Function.

Benecke AG, Eilebrecht S.

Biomolecules. 2015;5(2):943-57. Review.


Down-regulation of high mobility group-I(Y) protein contributes to the inhibition of nitric-oxide synthase 2 by transforming growth factor-beta1.

Pellacani A, Wiesel P, Razavi S, Vasilj V, Feinberg MW, Chin MT, Reeves R, Perrella MA.

J Biol Chem. 2001 Jan 12;276(2):1653-9.

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