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Items: 1 to 20 of 145

1.

A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs.

Soifer HS, Sano M, Sakurai K, Chomchan P, Saetrom P, Sherman MA, Collingwood MA, Behlke MA, Rossi JJ.

Nucleic Acids Res. 2008 Nov;36(20):6511-22. doi: 10.1093/nar/gkn687. Epub 2008 Oct 15.

2.

Dicer's helicase domain is required for accumulation of some, but not all, C. elegans endogenous siRNAs.

Welker NC, Pavelec DM, Nix DA, Duchaine TF, Kennedy S, Bass BL.

RNA. 2010 May;16(5):893-903. doi: 10.1261/rna.2122010. Epub 2010 Mar 30.

3.

In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs.

Gurtan AM, Lu V, Bhutkar A, Sharp PA.

RNA. 2012 Jun;18(6):1116-22. doi: 10.1261/rna.032680.112. Epub 2012 Apr 30.

4.

Single processing center models for human Dicer and bacterial RNase III.

Zhang H, Kolb FA, Jaskiewicz L, Westhof E, Filipowicz W.

Cell. 2004 Jul 9;118(1):57-68.

5.

Recognition of the pre-miRNA structure by Drosophila Dicer-1.

Tsutsumi A, Kawamata T, Izumi N, Seitz H, Tomari Y.

Nat Struct Mol Biol. 2011 Sep 18;18(10):1153-8. doi: 10.1038/nsmb.2125.

PMID:
21926993
6.

Evolutionarily conserved roles of the dicer helicase domain in regulating RNA interference processing.

Kidwell MA, Chan JM, Doudna JA.

J Biol Chem. 2014 Oct 10;289(41):28352-62. doi: 10.1074/jbc.M114.589051. Epub 2014 Aug 18.

7.

How short RNAs impact the human ribonuclease Dicer activity: putative regulatory feedback-loops and other RNA-mediated mechanisms controlling microRNA processing.

Koralewska N, Hoffmann W, Pokornowska M, Milewski M, Lipinska A, Bienkowska-Szewczyk K, Figlerowicz M, Kurzynska-Kokorniak A.

Acta Biochim Pol. 2016;63(4):773-783. Epub 2016 Oct 13.

8.

Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain.

Fukunaga R, Colpan C, Han BW, Zamore PD.

EMBO J. 2014 Feb 18;33(4):371-84. doi: 10.1002/embj.201387176. Epub 2014 Jan 31.

9.

Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease.

Cenik ES, Fukunaga R, Lu G, Dutcher R, Wang Y, Tanaka Hall TM, Zamore PD.

Mol Cell. 2011 Apr 22;42(2):172-84. doi: 10.1016/j.molcel.2011.03.002. Epub 2011 Mar 17.

10.

Substrate-specific kinetics of Dicer-catalyzed RNA processing.

Chakravarthy S, Sternberg SH, Kellenberger CA, Doudna JA.

J Mol Biol. 2010 Dec 3;404(3):392-402. doi: 10.1016/j.jmb.2010.09.030. Epub 2010 Oct 13.

11.

The role of human Dicer-dsRBD in processing small regulatory RNAs.

Wostenberg C, Lary JW, Sahu D, Acevedo R, Quarles KA, Cole JL, Showalter SA.

PLoS One. 2012;7(12):e51829. doi: 10.1371/journal.pone.0051829. Epub 2012 Dec 13.

12.

Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila.

Lim DH, Kim J, Kim S, Carthew RW, Lee YS.

Biochem Biophys Res Commun. 2008 Jul 4;371(3):525-30. doi: 10.1016/j.bbrc.2008.04.118. Epub 2008 Apr 30.

13.

A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis.

Fukunaga R, Zamore PD.

Cell Cycle. 2014;13(11):1671-6. doi: 10.4161/cc.29066. Epub 2014 Apr 30.

14.

The C-terminal dsRNA-binding domain of Drosophila Dicer-2 is crucial for efficient and high-fidelity production of siRNA and loading of siRNA to Argonaute2.

Kandasamy SK, Zhu L, Fukunaga R.

RNA. 2017 Jul;23(7):1139-1153. doi: 10.1261/rna.059915.116. Epub 2017 Apr 17.

PMID:
28416567
15.

Dicer recognizes the 5' end of RNA for efficient and accurate processing.

Park JE, Heo I, Tian Y, Simanshu DK, Chang H, Jee D, Patel DJ, Kim VN.

Nature. 2011 Jul 13;475(7355):201-5. doi: 10.1038/nature10198.

16.

Molecular mechanisms that funnel RNA precursors into endogenous small-interfering RNA and microRNA biogenesis pathways in Drosophila.

Miyoshi K, Miyoshi T, Hartig JV, Siomi H, Siomi MC.

RNA. 2010 Mar;16(3):506-15. doi: 10.1261/rna.1952110. Epub 2010 Jan 19.

17.

Production of small RNAs by mammalian Dicer.

Svobodova E, Kubikova J, Svoboda P.

Pflugers Arch. 2016 Jun;468(6):1089-102. doi: 10.1007/s00424-016-1817-6. Epub 2016 Apr 6. Review.

18.

Substrate-specific structural rearrangements of human Dicer.

Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna JA, Wang HW.

Nat Struct Mol Biol. 2013 Jun;20(6):662-70. doi: 10.1038/nsmb.2564. Epub 2013 Apr 28.

19.

Structure of precursor microRNA's terminal loop regulates human Dicer's dicing activity by switching DExH/D domain.

Liu Z, Wang J, Li G, Wang HW.

Protein Cell. 2015 Mar;6(3):185-93. doi: 10.1007/s13238-014-0124-2. Epub 2014 Dec 31.

20.

Two-step cleavage of hairpin RNA with 5' overhangs by human DICER.

Ando Y, Maida Y, Morinaga A, Burroughs AM, Kimura R, Chiba J, Suzuki H, Masutomi K, Hayashizaki Y.

BMC Mol Biol. 2011 Feb 9;12:6. doi: 10.1186/1471-2199-12-6.

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