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FDH: an aldehyde dehydrogenase fusion enzyme in folate metabolism.

Krupenko SA.

Chem Biol Interact. 2009 Mar 16;178(1-3):84-93. doi: 10.1016/j.cbi.2008.09.007. Review.


Modular organization of FDH: Exploring the basis of hydrolase catalysis.

Reuland SN, Vlasov AP, Krupenko SA.

Protein Sci. 2006 May;15(5):1076-84.


Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes.

Strickland KC, Holmes RS, Oleinik NV, Krupenko NI, Krupenko SA.

Chem Biol Interact. 2011 May 30;191(1-3):122-8. doi: 10.1016/j.cbi.2010.12.025.


10-formyltetrahydrofolate dehydrogenase requires a 4'-phosphopantetheine prosthetic group for catalysis.

Donato H, Krupenko NI, Tsybovsky Y, Krupenko SA.

J Biol Chem. 2007 Nov 23;282(47):34159-66.


Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition.

Lin CC, Chuankhayan P, Chang WN, Kao TT, Guan HH, Fun HK, Nakagawa A, Fu TF, Chen CJ.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):1006-21. doi: 10.1107/S1399004715002928.


The mechanism of discrimination between oxidized and reduced coenzyme in the aldehyde dehydrogenase domain of Aldh1l1.

Tsybovsky Y, Malakhau Y, Strickland KC, Krupenko SA.

Chem Biol Interact. 2013 Feb 25;202(1-3):62-9. doi: 10.1016/j.cbi.2012.12.015.


Conserved catalytic residues of the ALDH1L1 aldehyde dehydrogenase domain control binding and discharging of the coenzyme.

Tsybovsky Y, Krupenko SA.

J Biol Chem. 2011 Jul 1;286(26):23357-67. doi: 10.1074/jbc.M111.221069.


Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase.

Strickland KC, Krupenko NI, Dubard ME, Hu CJ, Tsybovsky Y, Krupenko SA.

Chem Biol Interact. 2011 May 30;191(1-3):129-36. doi: 10.1016/j.cbi.2011.01.008.


ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase.

Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA.

J Biol Chem. 2010 Jul 23;285(30):23056-63. doi: 10.1074/jbc.M110.128843.


Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization.

Krupenko NI, Holmes RS, Tsybovsky Y, Krupenko SA.

Chem Biol Interact. 2015 Jun 5;234:12-7. doi: 10.1016/j.cbi.2014.12.022.


Leucovorin-induced resistance against FDH growth suppressor effects occurs through DHFR up-regulation.

Oleinik NV, Krupenko NI, Reuland SN, Krupenko SA.

Biochem Pharmacol. 2006 Jul 14;72(2):256-66.


Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase.

Anguera MC, Field MS, Perry C, Ghandour H, Chiang EP, Selhub J, Shane B, Stover PJ.

J Biol Chem. 2006 Jul 7;281(27):18335-42.

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