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Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer.

Provenzano PP, Inman DR, Eliceiri KW, Beggs HE, Keely PJ.

Am J Pathol. 2008 Nov;173(5):1551-65. doi: 10.2353/ajpath.2008.080308. Epub 2008 Oct 9.


Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.

Lahlou H, Sanguin-Gendreau V, Zuo D, Cardiff RD, McLean GW, Frame MC, Muller WJ.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20302-7. Epub 2007 Dec 3.


Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation.

van Miltenburg MH, van Nimwegen MJ, Tijdens I, Lalai R, Kuiper R, Klarenbeek S, Schouten PC, de Vries A, Jonkers J, van de Water B.

Br J Cancer. 2014 May 27;110(11):2747-55. doi: 10.1038/bjc.2014.219. Epub 2014 May 8.


Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.

Pylayeva Y, Gillen KM, Gerald W, Beggs HE, Reichardt LF, Giancotti FG.

J Clin Invest. 2009 Feb;119(2):252-66. doi: 10.1172/JCI37160. Epub 2009 Jan 19.


Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.

Peng M, Ball-Kell SM, Tyner AL.

Cell Death Dis. 2015 Aug 6;6:e1848. doi: 10.1038/cddis.2015.210.


Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation.

van Nimwegen MJ, Verkoeijen S, van Buren L, Burg D, van de Water B.

Cancer Res. 2005 Jun 1;65(11):4698-706.


Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo.

Fan H, Zhao X, Sun S, Luo M, Guan JL.

J Biol Chem. 2013 Feb 1;288(5):3322-33. doi: 10.1074/jbc.M112.420497. Epub 2012 Dec 19.


Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis.

Wendt MK, Schiemann WP.

Breast Cancer Res. 2009;11(5):R68. doi: 10.1186/bcr2360.


Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth.

Chang LC, Huang CH, Cheng CH, Chen BH, Chen HC.

J Biomed Sci. 2005;12(4):571-85. Epub 2005 Nov 10.


Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.

Lofgren KA, Ostrander JH, Housa D, Hubbard GK, Locatelli A, Bliss RL, Schwertfeger KL, Lange CA.

Breast Cancer Res. 2011 Sep 17;13(5):R89. doi: 10.1186/bcr2946.


Signal transduction by focal adhesion kinase in cancer.

Zhao J, Guan JL.

Cancer Metastasis Rev. 2009 Jun;28(1-2):35-49. doi: 10.1007/s10555-008-9165-4. Review.


Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis.

Marcotte R, Smith HW, Sanguin-Gendreau V, McDonough RV, Muller WJ.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2808-13. doi: 10.1073/pnas.1018861108. Epub 2011 May 31.


Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.

Walsh C, Tanjoni I, Uryu S, Tomar A, Nam JO, Luo H, Phillips A, Patel N, Kwok C, McMahon G, Stupack DG, Schlaepfer DD.

Cancer Biol Ther. 2010 May 15;9(10):778-90.


Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.

Luo M, Fan H, Nagy T, Wei H, Wang C, Liu S, Wicha MS, Guan JL.

Cancer Res. 2009 Jan 15;69(2):466-74. doi: 10.1158/0008-5472.CAN-08-3078.


Denbinobin suppresses breast cancer metastasis through the inhibition of Src-mediated signaling pathways.

Chen PH, Peng CY, Pai HC, Teng CM, Chen CC, Yang CR.

J Nutr Biochem. 2011 Aug;22(8):732-40. doi: 10.1016/j.jnutbio.2010.06.004. Epub 2010 Nov 9.


Glial cell-derived neurotrophic factor (GDNF)-induced migration and signal transduction in corneal epithelial cells.

You L, Ebner S, Kruse FE.

Invest Ophthalmol Vis Sci. 2001 Oct;42(11):2496-504.


PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo.

Ma JG, Huang H, Chen SM, Chen Y, Xin XL, Lin LP, Ding J, Liu H, Meng LH.

Breast Cancer Res Treat. 2011 Nov;130(1):85-96. doi: 10.1007/s10549-010-1302-4. Epub 2010 Dec 22.


p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis.

Cabodi S, Tinnirello A, Di Stefano P, BisarĂ² B, Ambrosino E, Castellano I, Sapino A, Arisio R, Cavallo F, Forni G, Glukhova M, Silengo L, Altruda F, Turco E, Tarone G, Defilippi P.

Cancer Res. 2006 May 1;66(9):4672-80.

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