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Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier.

Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV.

J Cereb Blood Flow Metab. 2009 Jan;29(1):25-33. doi: 10.1038/jcbfm.2008.117. Epub 2008 Oct 8.


The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis.

Kager LM, Roelofs JJ, de Vos AF, Wieland CW, Schouten M, Meijers JC, Isermann B, Van't Veer C, Esmon CT, van der Poll T.

Thromb Haemost. 2013 Apr;109(4):726-37. doi: 10.1160/TH12-11-0859. Epub 2013 Jan 24.


Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity.

Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV.

Eur J Neurosci. 2009 Mar;29(6):1119-30. doi: 10.1111/j.1460-9568.2009.06664.x.


Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, Mosnier LO, Castellino FJ, Mackman N, Griffin JH, Weiler H.

J Exp Med. 2007 Oct 1;204(10):2439-48. Epub 2007 Sep 24.


Activated protein C protects against ventilator-induced pulmonary capillary leak.

Finigan JH, Boueiz A, Wilkinson E, Damico R, Skirball J, Pae HH, Damarla M, Hasan E, Pearse DB, Reddy SP, Grigoryev DN, Cheadle C, Esmon CT, Garcia JG, Hassoun PM.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L1002-11. doi: 10.1152/ajplung.90555.2008. Epub 2009 Apr 10.


Cytoprotective-selective activated protein C therapy for ischaemic stroke.

Mosnier LO, Zlokovic BV, Griffin JH.

Thromb Haemost. 2014 Nov;112(5):883-92. doi: 10.1160/TH14-05-0448. Epub 2014 Sep 18. Review.


Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1.

Thiyagarajan M, Fernández JA, Lane SM, Griffin JH, Zlokovic BV.

J Neurosci. 2008 Nov 26;28(48):12788-97. doi: 10.1523/JNEUROSCI.3485-08.2008.


Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1.

Schuepbach RA, Feistritzer C, Fernández JA, Griffin JH, Riewald M.

Thromb Haemost. 2009 Apr;101(4):724-33.


Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

Kerschen E, Hernandez I, Zogg M, Jia S, Hessner MJ, Fernandez JA, Griffin JH, Huettner CS, Castellino FJ, Weiler H.

J Clin Invest. 2010 Sep;120(9):3167-78. doi: 10.1172/JCI42629. Epub 2010 Aug 16.


Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.

Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV.

Blood. 2003 Jun 15;101(12):4797-801. Epub 2003 Feb 13.


Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality.

Niessen F, Furlan-Freguia C, Fernández JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W.

Blood. 2009 Mar 19;113(12):2859-66. doi: 10.1182/blood-2008-12-192385. Epub 2009 Jan 13. Retraction in: Blood. 2011 Jun 30;117(26):7188.


Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury.

Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O'Donnell JS, Montes R, Preston RJ.

Blood. 2015 Aug 13;126(7):915-9. doi: 10.1182/blood-2015-03-632877. Epub 2015 Jun 17.


Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity.

Guo H, Wang Y, Singh I, Liu D, Fernández JA, Griffin JH, Chow N, Zlokovic BV.

J Neurochem. 2009 Apr;109(1):116-24. doi: 10.1111/j.1471-4159.2009.05921.x. Epub 2009 Jan 23.


Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells.

Feistritzer C, Schuepbach RA, Mosnier LO, Bush LA, Di Cera E, Griffin JH, Riewald M.

J Biol Chem. 2006 Jul 21;281(29):20077-84. Epub 2006 May 18.


The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b.

Cao C, Gao Y, Li Y, Antalis TM, Castellino FJ, Zhang L.

J Clin Invest. 2010 Jun;120(6):1971-80. doi: 10.1172/JCI40380. Epub 2010 May 10.


Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1.

Wang Y, Zhao Z, Chow N, Ali T, Griffin JH, Zlokovic BV.

Brain Res. 2013 Apr 24;1507:97-104. doi: 10.1016/j.brainres.2013.02.023. Epub 2013 Feb 21.


Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation.

Finigan JH, Dudek SM, Singleton PA, Chiang ET, Jacobson JR, Camp SM, Ye SQ, Garcia JG.

J Biol Chem. 2005 Apr 29;280(17):17286-93. Epub 2005 Feb 14.


Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.

Wang Y, Thiyagarajan M, Chow N, Singh I, Guo H, Davis TP, Zlokovic BV.

Stroke. 2009 May;40(5):1864-9. doi: 10.1161/STROKEAHA.108.536680. Epub 2008 Dec 4.


Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells.

Ní Ainle F, O'Donnell JS, Johnson JA, Brown L, Gleeson EM, Smith OP, Preston RJ.

J Biol Chem. 2011 Jan 14;286(2):1323-30. doi: 10.1074/jbc.M110.159475. Epub 2010 Nov 2.

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