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Items: 1 to 20 of 112

1.

The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b).

He J, Kallin EM, Tsukada Y, Zhang Y.

Nat Struct Mol Biol. 2008 Nov;15(11):1169-75. doi: 10.1038/nsmb.1499. Epub 2008 Oct 5.

2.

Depletion of histone demethylase KDM2A inhibited cell proliferation of stem cells from apical papilla by de-repression of p15INK4B and p27Kip1.

Gao R, Dong R, Du J, Ma P, Wang S, Fan Z.

Mol Cell Biochem. 2013 Jul;379(1-2):115-22. doi: 10.1007/s11010-013-1633-7. Epub 2013 Apr 5.

PMID:
23559091
3.

JmjC-domain containing histone demethylase 1B-mediated p15(Ink4b) suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in acute myeloid leukemia.

Nakamura S, Tan L, Nagata Y, Takemura T, Asahina A, Yokota D, Yagyu T, Shibata K, Fujisawa S, Ohnishi K.

Mol Carcinog. 2013 Jan;52(1):57-69. doi: 10.1002/mc.20878. Epub 2011 Nov 15.

PMID:
22086844
4.

Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.

Tzatsos A, Paskaleva P, Lymperi S, Contino G, Stoykova S, Chen Z, Wong KK, Bardeesy N.

J Biol Chem. 2011 Sep 23;286(38):33061-9. doi: 10.1074/jbc.M111.257667. Epub 2011 Jul 11.

5.

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia.

He J, Nguyen AT, Zhang Y.

Blood. 2011 Apr 7;117(14):3869-80. doi: 10.1182/blood-2010-10-312736. Epub 2011 Feb 10.

6.

Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus.

Jie B, Weilong C, Ming C, Fei X, Xinghua L, Junhua C, Guobin W, Kaixiong T, Xiaoming S.

Int J Biochem Cell Biol. 2015 Aug;65:104-12. doi: 10.1016/j.biocel.2015.05.011. Epub 2015 May 22.

PMID:
26004298
7.

JHDM1B expression regulates ribosome biogenesis and cancer cell growth in a p53 dependent manner.

Penzo M, Casoli L, Pollutri D, Sicuro L, Ceccarelli C, Santini D, Taffurelli M, Govoni M, Brina D, Trerè D, Montanaro L.

Int J Cancer. 2015 Mar 1;136(5):E272-81. doi: 10.1002/ijc.29240. Epub 2014 Oct 10.

8.

Upregulation of chicken p15INK4b at senescence and in the developing brain.

Kim SH, Rowe J, Fujii H, Jones R, Schmierer B, Kong BW, Kuchler K, Foster D, Ish-Horowicz D, Peters G.

J Cell Sci. 2006 Jun 15;119(Pt 12):2435-43. Epub 2006 May 23.

9.

The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner.

Wang T, Chen K, Zeng X, Yang J, Wu Y, Shi X, Qin B, Zeng L, Esteban MA, Pan G, Pei D.

Cell Stem Cell. 2011 Dec 2;9(6):575-87. doi: 10.1016/j.stem.2011.10.005. Epub 2011 Nov 17.

10.

Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b).

Malumbres M, Pérez De Castro I, Hernández MI, Jiménez M, Corral T, Pellicer A.

Mol Cell Biol. 2000 Apr;20(8):2915-25.

11.

Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.

Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Hirao A, Yanagi S, Fukami K, Ishikawa Y, Sone S, Hara E, Ohtani N.

Cancer Res. 2010 Nov 15;70(22):9381-90. doi: 10.1158/0008-5472.CAN-10-0801. Epub 2010 Nov 9.

12.

JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes.

Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R, Pagano M.

Nature. 2007 Nov 8;450(7167):309-13.

PMID:
17994099
13.

The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblasts.

Janzer A, Stamm K, Becker A, Zimmer A, Buettner R, Kirfel J.

J Biol Chem. 2012 Sep 7;287(37):30984-92. doi: 10.1074/jbc.M112.341040. Epub 2012 Jul 23.

14.

Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence.

Shin J, Yang J, Lee JC, Baek KH.

Cell Signal. 2013 Dec;25(12):2540-7. doi: 10.1016/j.cellsig.2013.08.014. Epub 2013 Aug 30.

PMID:
23993963
15.

INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform.

Tian X, Azpurua J, Ke Z, Augereau A, Zhang ZD, Vijg J, Gladyshev VN, Gorbunova V, Seluanov A.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1053-8. doi: 10.1073/pnas.1418203112. Epub 2014 Dec 30.

16.

Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health.

Popov N, Gil J.

Epigenetics. 2010 Nov-Dec;5(8):685-90. Epub 2010 Nov 1. Review.

17.

Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process.

Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE, Tsichlis PN.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1907-12. doi: 10.1073/pnas.0711865105. Epub 2008 Feb 4.

18.

A systematic study of the cellular metabolic regulation of Jhdm1b in tumor cells.

Yu X, Wang J, Wu J, Shi Y.

Mol Biosyst. 2015 Jul;11(7):1867-75. doi: 10.1039/c5mb00166h.

PMID:
25877602
19.

The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.

Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J.

J Biol Chem. 2015 Feb 13;290(7):4163-77. doi: 10.1074/jbc.M114.626929. Epub 2014 Dec 22.

20.

The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators.

Kawakami E, Tokunaga A, Ozawa M, Sakamoto R, Yoshida N.

Mech Dev. 2015 Feb;135:31-42. doi: 10.1016/j.mod.2014.10.001. Epub 2014 Oct 30.

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