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Items: 1 to 20 of 97


Cutting edge: TLR ligands increase TCR triggering by slowing peptide-MHC class I decay rates.

Rudd BD, Brien JD, Davenport MP, Nikolich-Zugich J.

J Immunol. 2008 Oct 15;181(8):5199-203.


Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling.

Anikeeva N, Gakamsky D, Schøller J, Sykulev Y.

PLoS One. 2012;7(8):e41466. doi: 10.1371/journal.pone.0041466. Epub 2012 Aug 3.


Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands.

Grossmann C, Tenbusch M, Nchinda G, Temchura V, Nabi G, Stone GW, Kornbluth RS, Uberla K.

BMC Immunol. 2009 Aug 3;10:43. doi: 10.1186/1471-2172-10-43.


Presentation of type B peptide-MHC complexes from hen egg white lysozyme by TLR ligands and type I IFNs independent of H2-DM regulation.

Strong BS, Unanue ER.

J Immunol. 2011 Sep 1;187(5):2193-201. doi: 10.4049/jimmunol.1100152. Epub 2011 Jul 25.


Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity.

Engels B, Chervin AS, Sant AJ, Kranz DM, Schreiber H.

Mol Ther. 2012 Mar;20(3):652-60. doi: 10.1038/mt.2011.286. Epub 2012 Jan 10.


T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with TAP-Independent Peptides Are Semi-Invariant Lymphocytes.

Doorduijn EM, Sluijter M, Querido BJ, Seidel UJE, Oliveira CC, van der Burg SH, van Hall T.

Front Immunol. 2018 Jan 25;9:60. doi: 10.3389/fimmu.2018.00060. eCollection 2018.


CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement.

Stone JD, Stern LJ.

J Immunol. 2006 Feb 1;176(3):1498-505. Erratum in: J Immunol. 2006 Mar 15;176(6):3843.


Dendritic cells recruit T cell exosomes via exosomal LFA-1 leading to inhibition of CD8+ CTL responses through downregulation of peptide/MHC class I and Fas ligand-mediated cytotoxicity.

Xie Y, Zhang H, Li W, Deng Y, Munegowda MA, Chibbar R, Qureshi M, Xiang J.

J Immunol. 2010 Nov 1;185(9):5268-78. doi: 10.4049/jimmunol.1000386. Epub 2010 Sep 29.


Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells.

Khan S, Bijker MS, Weterings JJ, Tanke HJ, Adema GJ, van Hall T, Drijfhout JW, Melief CJ, Overkleeft HS, van der Marel GA, Filippov DV, van der Burg SH, Ossendorp F.

J Biol Chem. 2007 Jul 20;282(29):21145-59. Epub 2007 Apr 26.


Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific.

Wu J, Meng Z, Jiang M, Zhang E, Trippler M, Broering R, Bucchi A, Krux F, Dittmer U, Yang D, Roggendorf M, Gerken G, Lu M, Schlaak JF.

Immunology. 2010 Mar;129(3):363-74. doi: 10.1111/j.1365-2567.2009.03179.x. Epub 2009 Nov 16.


TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

Huppa JB, Axmann M, Mörtelmaier MA, Lillemeier BF, Newell EW, Brameshuber M, Klein LO, Schütz GJ, Davis MM.

Nature. 2010 Feb 18;463(7283):963-7. doi: 10.1038/nature08746.


CD4+ T cells mature in the absence of MHC class I and class II expression in Ly-6A.2 transgenic mice.

Henderson SC, Berezovskaya A, English A, Palliser D, Rock KL, Bamezai A.

J Immunol. 1998 Jul 1;161(1):175-82.


TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8α+ conventional dendritic cells by enhancing antigen preservation and MHC class I antigen permanence on the dendritic cell surface.

Crespo MI, Zacca ER, Núñez NG, Ranocchia RP, Maccioni M, Maletto BA, Pistoresi-Palencia MC, Morón G.

J Immunol. 2013 Feb 1;190(3):948-60. doi: 10.4049/jimmunol.1102725. Epub 2013 Jan 2.


Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells.

Hong J, Persaud SP, Horvath S, Allen PM, Evavold BD, Zhu C.

J Immunol. 2015 Oct 15;195(8):3557-64. doi: 10.4049/jimmunol.1501407. Epub 2015 Sep 2.


Comparison of antibodies and carbohydrates to target vaccines to human dendritic cells via DC-SIGN.

Cruz LJ, Tacken PJ, Pots JM, Torensma R, Buschow SI, Figdor CG.

Biomaterials. 2012 Jun;33(16):4229-39. doi: 10.1016/j.biomaterials.2012.02.036. Epub 2012 Mar 10.


TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism.

Jones SC, Brahmakshatriya V, Huston G, Dibble J, Swain SL.

J Immunol. 2010 Dec 1;185(11):6783-94. doi: 10.4049/jimmunol.0901296. Epub 2010 Oct 27.


Extent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses.

Anikeeva N, Fischer NO, Blanchette CD, Sykulev Y.

J Immunol. 2019 Jan 15;202(2):591-597. doi: 10.4049/jimmunol.1801196. Epub 2018 Dec 12.

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