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Items: 1 to 20 of 104


Persistent expression of PEDF in the eye using high-capacity adenovectors.

Chen P, Hamilton M, Thomas CA, Kroeger K, Carrion M, Macgill RS, Gehlbach P, Brough DE, Wei LL, King CR, Bruder JT.

Mol Ther. 2008 Dec;16(12):1986-94. doi: 10.1038/mt.2008.211. Epub 2008 Sep 30.


Alternate serotype adenovector provides long-term therapeutic gene expression in the eye.

Hamilton MM, Byrnes GA, Gall JG, Brough DE, King CR, Wei LL.

Mol Vis. 2008;14:2535-46. Epub 2008 Dec 30.


Adenoviral gene delivery of pigment epithelium-derived factor protects striatal neurons from quinolinic acid-induced excitotoxicity.

Sanagi T, Yabe T, Yamada H.

J Neuropathol Exp Neurol. 2010 Mar;69(3):224-33. doi: 10.1097/NEN.0b013e3181cfc46f.


Periocular injection of an adenoviral vector encoding pigment epithelium-derived factor inhibits choroidal neovascularization.

Gehlbach P, Demetriades AM, Yamamoto S, Deering T, Duh EJ, Yang HS, Cingolani C, Lai H, Wei L, Campochiaro PA.

Gene Ther. 2003 Apr;10(8):637-46.


AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization.

Mori K, Gehlbach P, Yamamoto S, Duh E, Zack DJ, Li Q, Berns KI, Raisler BJ, Hauswirth WW, Campochiaro PA.

Invest Ophthalmol Vis Sci. 2002 Jun;43(6):1994-2000.


Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor.

Mori K, Gehlbach P, Ando A, McVey D, Wei L, Campochiaro PA.

Invest Ophthalmol Vis Sci. 2002 Jul;43(7):2428-34.


Periocular gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization in a human-sized eye.

Saishin Y, Silva RL, Saishin Y, Kachi S, Aslam S, Gong YY, Lai H, Carrion M, Harris B, Hamilton M, Wei L, Campochiaro PA.

Hum Gene Ther. 2005 Apr;16(4):473-8.


Anti-tumor effect of adenovirus-mediated gene transfer of pigment epithelium-derived factor on mouse B16-F10 melanoma.

Yang LP, Cheng P, Peng XC, Shi HS, He WH, Cui FY, Luo ST, Wei YQ, Yang L.

J Exp Clin Cancer Res. 2009 Jun 5;28:75. doi: 10.1186/1756-9966-28-75.


Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization.

Mori K, Duh E, Gehlbach P, Ando A, Takahashi K, Pearlman J, Mori K, Yang HS, Zack DJ, Ettyreddy D, Brough DE, Wei LL, Campochiaro PA.

J Cell Physiol. 2001 Aug;188(2):253-63.


Enhanced efficacy of combination therapy with adeno‚ÄĎassociated virus-delivered pigment epithelium-derived factor and cisplatin in a mouse model of Lewis lung carcinoma.

He SS, Wu QJ, Gong CY, Luo ST, Zhang S, Li M, Lu L, Wei YQ, Yang L.

Mol Med Rep. 2014 Jun;9(6):2069-76. doi: 10.3892/mmr.2014.2117. Epub 2014 Apr 4.


Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis.

Yang H, Grossniklaus HE.

Invest Ophthalmol Vis Sci. 2010 Jan;51(1):28-34. doi: 10.1167/iovs.09-4138. Epub 2009 Aug 6.


Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD).

Rasmussen H, Chu KW, Campochiaro P, Gehlbach PL, Haller JA, Handa JT, Nguyen QD, Sung JU.

Hum Gene Ther. 2001 Nov 1;12(16):2029-32.


Repeat administration of proteins to the eye with a single intraocular injection of an adenovirus vector.

McVey D, Hamilton MM, Hsu C, King CR, Brough DE, Wei LL.

Mol Ther. 2008 Aug;16(8):1444-9. doi: 10.1038/mt.2008.124. Epub 2008 Jun 10.


Therapeutic potential of bone marrow-derived mesenchymal stem cells producing pigment epithelium-derived factor in lung carcinoma.

Chen Q, Cheng P, Yin T, He H, Yang L, Wei Y, Chen X.

Int J Mol Med. 2012 Sep;30(3):527-34. doi: 10.3892/ijmm.2012.1015. Epub 2012 Jun 6.


Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway.

He X, Cheng R, Park K, Benyajati S, Moiseyev G, Sun C, Olson LE, Yang Y, Eby BK, Lau K, Ma JX.

Kidney Int. 2017 Mar;91(3):642-657. doi: 10.1016/j.kint.2016.09.036. Epub 2016 Dec 1.


Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia.

Notari L, Miller A, Martínez A, Amaral J, Ju M, Robinson G, Smith LE, Becerra SP.

Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2736-47.


Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential.

Li Q, Miller R, Han PY, Pang J, Dinculescu A, Chiodo V, Hauswirth WW.

Mol Vis. 2008 Sep 24;14:1760-9.


Mesenchymal Stem Cells Engineered to Secrete Pigment Epithelium-Derived Factor Inhibit Tumor Metastasis and the Formation of Malignant Ascites in a Murine Colorectal Peritoneal Carcinomatosis Model.

Yang L, Zhang Y, Cheng L, Yue D, Ma J, Zhao D, Hou X, Xiang R, Cheng P.

Hum Gene Ther. 2016 Mar;27(3):267-77. doi: 10.1089/hum.2015.135. Epub 2016 Feb 22.


Salutary effect of pigment epithelium-derived factor in diabetic nephropathy: evidence for antifibrogenic activities.

Wang JJ, Zhang SX, Mott R, Knapp RR, Cao W, Lau K, Ma JX.

Diabetes. 2006 Jun;55(6):1678-85.


AAV-mediated gene transfer of human pigment epithelium-derived factor inhibits Lewis lung carcinoma growth in mice.

He SS, Shi HS, Yin T, Li YX, Luo ST, Wu QJ, Lu L, Wei YQ, Yang L.

Oncol Rep. 2012 Apr;27(4):1142-8. doi: 10.3892/or.2012.1621. Epub 2012 Jan 4.

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